ES2029285T3 - A PROCEDURE FOR THE PREPARATION OF A GRANULATED NUCLEUS OF RAPID DISGREGATION. - Google Patents

A PROCEDURE FOR THE PREPARATION OF A GRANULATED NUCLEUS OF RAPID DISGREGATION.

Info

Publication number
ES2029285T3
ES2029285T3 ES198787850052T ES87850052T ES2029285T3 ES 2029285 T3 ES2029285 T3 ES 2029285T3 ES 198787850052 T ES198787850052 T ES 198787850052T ES 87850052 T ES87850052 T ES 87850052T ES 2029285 T3 ES2029285 T3 ES 2029285T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
rapid
nucleus
granulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787850052T
Other languages
Spanish (es)
Inventor
Curt Henry Appelgren
Eva Christina Eskilsson
Jonas Paul Uvdal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lejus Medical AB
Original Assignee
Lejus Medical AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lejus Medical AB filed Critical Lejus Medical AB
Application granted granted Critical
Publication of ES2029285T3 publication Critical patent/ES2029285T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Mushroom Cultivation (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UN GRANULADO DE RAPIDA DESINTEGRACION DEL NUCLEO QUE CONTIENE UN COMPUESTO ACTIVO FARMACEUTICAMENTE. TAL GRANULADO SE DESTINA OPCIONALMENTE PARA SER RECUBIERTO CON UN REVESTIMIENTO QUE DETERMINA SU LIBERACION, ASI COMO TALES NUCLEOS A LOS QUE SE AÑADE UN COMPUESTO ACTIVO FARMACEUTICAMENTE, OPCIONALMENTE JUNTO CON UN EMULSIONANTE, UN SOLVENTE, Y OPCIONALMENTE TRATA LA COMPOSICION OBTENIDA INTENSIVAMENTE, OPCIONALMENTE SE REDUCE EL TAMAÑO DE LA PARTICULA, DISTRIBUYE LA OBTENIDA COMPOSICION TRATADA SOBRE UNA CAPA DE UN SOLIDO, PREFERIBLEMENTE DE MATERIAL SOLUBLE EN AGUA, Y SECA LOS AGLOMERADOS, ASI OBTENIDOS PARA FORMAR UN GRANULADO EN EL NUCLEO DE RAPIDA DESINTEGRACION.THE PRESENT INVENTION REFERS TO A PROCEDURE FOR THE PREPARATION OF A RAPID DISINTEGRATION GRANULATE OF THE NUCLEUS CONTAINING A PHARMACEUTICALLY ACTIVE COMPOUND. SUCH GRANULATE IS OPTIONALLY INTENDED TO BE COATED WITH A COATING THAT DETERMINES ITS RELEASE, AS WELL AS SUCH CORES TO WHICH A PHARMACEUTICALLY ACTIVE COMPOUND IS ADDED, OPTIONALLY SEVERELY PURPOSE, AND OPTIONALLY PURPOSE. THE SIZE OF THE PARTICLE, DISTRIBUTES THE OBTAINED COMPOSITION TREATED ON A LAYER OF A SOLID, PREFERABLY OF MATERIAL SOLUBLE IN WATER, AND DRIES THE AGGLOMERATES, SO AS TO OBTAIN A GRANULATE IN THE NUCLEUS OF RAPID DISINTEGRATION.

ES198787850052T 1986-02-14 1987-02-13 A PROCEDURE FOR THE PREPARATION OF A GRANULATED NUCLEUS OF RAPID DISGREGATION. Expired - Lifetime ES2029285T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8600657A SE457326B (en) 1986-02-14 1986-02-14 PROCEDURES FOR PREPARING A QUICK SUBSTANTIAL CANDLES CONTAINING BLA MICROCRISTALLIN CELLULOSA

Publications (1)

Publication Number Publication Date
ES2029285T3 true ES2029285T3 (en) 1992-08-01

Family

ID=20363470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787850052T Expired - Lifetime ES2029285T3 (en) 1986-02-14 1987-02-13 A PROCEDURE FOR THE PREPARATION OF A GRANULATED NUCLEUS OF RAPID DISGREGATION.

Country Status (9)

Country Link
US (1) US4840799A (en)
EP (1) EP0237506B1 (en)
AT (1) ATE66141T1 (en)
CA (1) CA1297018C (en)
DE (1) DE3772072D1 (en)
ES (1) ES2029285T3 (en)
FI (1) FI90725C (en)
GR (1) GR3002770T3 (en)
SE (1) SE457326B (en)

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Also Published As

Publication number Publication date
SE8600657L (en) 1987-08-15
GR3002770T3 (en) 1993-01-25
EP0237506A1 (en) 1987-09-16
FI90725C (en) 1994-03-25
FI871380L (en) 1988-10-01
SE8600657D0 (en) 1986-02-14
EP0237506B1 (en) 1991-08-14
SE457326B (en) 1988-12-19
FI871380A0 (en) 1987-03-30
ATE66141T1 (en) 1991-08-15
US4840799A (en) 1989-06-20
CA1297018C (en) 1992-03-10
DE3772072D1 (en) 1991-09-19
FI90725B (en) 1993-12-15

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