ES2029812T3 - Un procedimiento para preparar alfa-alquil-4-amino-3-quinolina-metanoles y 1-(4-aralquilamino-3-quinolil)alcanonas. - Google Patents

Un procedimiento para preparar alfa-alquil-4-amino-3-quinolina-metanoles y 1-(4-aralquilamino-3-quinolil)alcanonas.

Info

Publication number
ES2029812T3
ES2029812T3 ES198787112131T ES87112131T ES2029812T3 ES 2029812 T3 ES2029812 T3 ES 2029812T3 ES 198787112131 T ES198787112131 T ES 198787112131T ES 87112131 T ES87112131 T ES 87112131T ES 2029812 T3 ES2029812 T3 ES 2029812T3
Authority
ES
Spain
Prior art keywords
alkyl
alcanonas
methanols
aralkylamino
quinolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787112131T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2029812T3 publication Critical patent/ES2029812T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE LA FORMULA (I) DONDE X ES HIDROGENO, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR O TROFLUOROMETILO; R ES -C-R4 O -C-OH-R4, SIENDO R4 ALQUILO INFERIOR; R1 ES HIDROGENO, ALQUILO INFERIOR O ARILALQUILO INFERIOR; R2 ES HIDROGENO, ALQUILO INFERIOR O ARILALQUILO INFERIOR; Y R3 ES ALQUILO INFERIOR, CON LA CONDICION DE QUE CUANDO R SEA ACETILO, R3 ES METILO Y X ES HIDROGENO, R1 Y R2 NO SON AMBOS HIDROGENO O SALES DE ADICION DE ACIDOS ACEPTABLES FARMACEUTICAMENTE DEL MISMO, LAS CUALES SON UTILIZADAS PARA LA MEJORIA DE LA MEMORIA Y PARA EL TRATAMIENTO DE LA ENFERNEDAD DE ALZHEINER.
ES198787112131T 1986-08-25 1987-08-21 Un procedimiento para preparar alfa-alquil-4-amino-3-quinolina-metanoles y 1-(4-aralquilamino-3-quinolil)alcanonas. Expired - Lifetime ES2029812T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/899,584 US4789678A (en) 1986-08-25 1986-08-25 Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds

Publications (1)

Publication Number Publication Date
ES2029812T3 true ES2029812T3 (es) 1992-10-01

Family

ID=25411249

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787112131T Expired - Lifetime ES2029812T3 (es) 1986-08-25 1987-08-21 Un procedimiento para preparar alfa-alquil-4-amino-3-quinolina-metanoles y 1-(4-aralquilamino-3-quinolil)alcanonas.

Country Status (19)

Country Link
US (1) US4789678A (es)
EP (1) EP0258755B1 (es)
JP (1) JPS6360968A (es)
KR (1) KR880002834A (es)
AT (2) ATE67189T1 (es)
AU (1) AU589029B2 (es)
CA (1) CA1297111C (es)
DE (1) DE3772905D1 (es)
DK (1) DK441187A (es)
ES (1) ES2029812T3 (es)
FI (1) FI86299C (es)
GR (1) GR3003299T3 (es)
HU (1) HU199425B (es)
IL (1) IL83629A (es)
NO (1) NO873568L (es)
NZ (1) NZ221543A (es)
PH (1) PH25571A (es)
PT (1) PT85583B (es)
ZA (1) ZA876254B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581382B1 (fr) * 1985-05-06 1987-06-26 Sanofi Sa Derives n-(quinolyl) glycinamides, leur procede de preparation et leur application therapeutique en tant que psychotropes
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
US4743601A (en) * 1987-07-13 1988-05-10 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-1,4-oxazino(2,3-C)quinolines
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5019574A (en) * 1988-09-30 1991-05-28 Chugai Seiyaku Kabushiki Kaisha 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
US5110815A (en) * 1990-12-03 1992-05-05 Hoechst-Roussel Pharmaceuticals Inc. 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use
GB9122051D0 (en) * 1991-10-17 1991-11-27 Univ Nottingham Medicines
US5493027A (en) * 1993-01-22 1996-02-20 Board Of Regents, The University Of Texas System Anticonvulsive agents and uses thereof
YU19302A (sh) * 1999-09-22 2004-11-25 Aventis Pharma Deutschland Gmbh. 4-benzilaminohinolin konjugovan žučnom kiselinom i njegovi heteroanalozi, postupak za njihovu proizvodnju, lekovi koji sadrže ta jedinjenja i njihova primena
EP2178842A2 (en) 2007-08-22 2010-04-28 Abbott GmbH & Co. KG 4-benzylaminoquinolines, pharmaceutical compositions containing them and their use
ES2397764T3 (es) 2008-04-01 2013-03-11 Abbott Gmbh & Co. Kg Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2014521682A (ja) 2011-08-05 2014-08-28 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー アミノクロマン、アミノチオクロマンおよびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用
EP2780328A1 (en) 2011-11-18 2014-09-24 Abbvie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015055771A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2016004936A (es) 2013-10-17 2016-12-20 Abbvie Deutschland Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785165A (en) * 1953-12-22 1957-03-12 Abbott Lab Preparation of 4-aminoquinoline
US3391146A (en) * 1964-11-10 1968-07-02 Bristol Myers Co Nu-substituted carbamates and thiocarbamates of 2-quinolinemethanols
US4180670A (en) * 1977-02-02 1979-12-25 John Wyeth & Brother Limited Amino pyridine derivatives
FR2498187A1 (fr) * 1981-01-16 1982-07-23 Rhone Poulenc Sante Procede de preparation d'amino-4 chloro-7 quinoleines
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states

Also Published As

Publication number Publication date
DK441187A (da) 1988-02-26
FI873631A0 (fi) 1987-08-21
DE3772905D1 (de) 1991-10-17
PT85583B (pt) 1990-05-31
AU7734387A (en) 1988-02-25
AU589029B2 (en) 1989-09-28
KR880002834A (ko) 1988-05-11
EP0258755A1 (en) 1988-03-09
IL83629A (en) 1992-02-16
GR3003299T3 (en) 1993-02-17
HU199425B (en) 1990-02-28
ATA260187A (de) 1989-01-15
ATE67189T1 (de) 1991-09-15
DK441187D0 (da) 1987-08-24
FI86299B (fi) 1992-04-30
US4789678A (en) 1988-12-06
PH25571A (en) 1991-08-08
IL83629A0 (en) 1988-01-31
JPS6360968A (ja) 1988-03-17
NZ221543A (en) 1990-09-26
NO873568D0 (no) 1987-08-24
ZA876254B (en) 1988-04-27
AT388729B (de) 1989-08-25
FI86299C (fi) 1992-08-10
NO873568L (no) 1988-02-26
EP0258755B1 (en) 1991-09-11
HUT45503A (en) 1988-07-28
PT85583A (en) 1987-09-01
FI873631A7 (fi) 1988-02-26
CA1297111C (en) 1992-03-10

Similar Documents

Publication Publication Date Title
ES2062974T3 (es) Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos.
SE8503922L (sv) Analgetiska 1,2-bensisotiazol-3-ylpiperazin-derivat
PH25571A (en) Alpha'-alkyl-4-amino-3-quinolinemethanols, 1-(4-aralkylamino-3-quinolinyl) alaknones, their use as medicaments
ES547795A0 (es) Procedimiento para preparar acidos propano-fosfonosos susti-tuidos
ES486349A1 (es) Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas
AR240909A2 (es) Derivados de 2-(2'-alquilbenzoil) -1,3-ciclohexanodiona, composicion que los comprende y procedimiento para prepararlo"
CO4520226A1 (es) Compuestos carbociclicos
ES2108717T3 (es) Derivados de la tetrahidropirrolo(1,2-a)pirazina-4-espiro-3'-pirrolidina, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
SE8703169L (sv) 1-(4-aminofenyl)-4-metyl-7,8-metylendioxi-3,4-dihydro-5h-2,3-bensodiazepin, syraadditionssalter derav samt forfarande for framstellning av densamma
NO880843L (no) 3-amino-dihydro-(1)-benzopyraner og benzotiopyraner.
ATE96822T1 (de) Benzotriazolgruppenhaltiges diorganopolysiloxan.
ATE79257T1 (de) Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
ES2058449T3 (es) Nuevas piperazinilalquil-3(2h)-piridazinonas, procedimiento para su obtencion y su empleo como agentes reductores de la presion sanguinea.
DK55683D0 (da) Fungicide indanylbenzamider samt fremgangsmade til fremstilling heraf
ATE57917T1 (de) Hydroxipyrazol-derivate- verfahren zu ihrer herstellung und ihre verwendung gegen mikroorganismen.
ES2062819T3 (es) Compuestos heterociclicos, y su preparacion y uso.
ES2081834T3 (es) Pirrolidin-2-onas 4-metil y 4-etil sustituidas.
FR2726271B1 (fr) Derives de 6-polyfluoroalcoxy-2-aminobenzothiazole
SE8201506L (sv) Nya fluorprostacykliner
ES525670A0 (es) Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina
ES2041644T3 (es) Derivados de n-(piperidilaminocarbonil) quinoleincarboxamida que tienen actividad psicotropica.
NO164352C (no) Analogifremgangsmaate for fremstilling av farmasoeytisk aktive, antivirale, substituerte isoksazolderivater.
AR032373A2 (es) Intermediarios para preparar 3-(1-piperazinil)-1,2-benzoisotiazol.
PT900082E (pt) Utilizacao de piridilpiperazina e pirimidilpiperazina para o fabrico de um medicamento para o tratamento de perturbacoes de toxicomania
ES2150564T3 (es) Proceso para la preparacion de derivados de 5,6-dihidroxi-2-amino-1,2,3,4-tetrahidronaftaleno.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 258755

Country of ref document: ES