ES2031974T3 - Procedimiento para la obtencion de 3-amino-1-bencil piprolidinas. - Google Patents

Procedimiento para la obtencion de 3-amino-1-bencil piprolidinas.

Info

Publication number
ES2031974T3
ES2031974T3 ES198888115370T ES88115370T ES2031974T3 ES 2031974 T3 ES2031974 T3 ES 2031974T3 ES 198888115370 T ES198888115370 T ES 198888115370T ES 88115370 T ES88115370 T ES 88115370T ES 2031974 T3 ES2031974 T3 ES 2031974T3
Authority
ES
Spain
Prior art keywords
bencil
formula
amino
dionas
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888115370T
Other languages
English (en)
Inventor
Andreas Dr. Krebs
Thomas Dr. Schenke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2031974T3 publication Critical patent/ES2031974T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESO DE PRODUCCION DE 3 - AMINO - 1 - BENCIL - PIRROLIDINAS DE FORMULA(I), DONDE R1 Y R2 SON IGUALES O DIFERENTES Y SON RESPECTIVAMENTE H O ALQUILO, MEDIANTE REACCION DE 1 - BENCIL - 3 PIRROLIN - 2,5 - DIONAS DE FORMULA(II) CON NUCLEOFILOS DE NITROGENO DE FORMULA (III) PARA CONSEGUIR 3 - AMINO - 1 - BENCIL - PIRROLIDIN - 2,5 - DIONAS, SUSTITUIDAS EN SU CASO, DE FORMULA (IV), SIENDO EN LA FORMULA (III) R3 Y R4 (IGUALES O DISTINTOS) H O ALQUILO, R5 H, BENCILO, NAFTILMETILO O UN SUSTITUYENTE FENIL CHR6, CON R6 ES C1 C6 - ALQUILO O FENILO, TENIENDO R1 Y R2 EL SIGNIFICADO DADO ANTERIORMENTE, Y POSTERIOR DIVISION DEL GRUPO PROTECTOR R5 PARA EL CASO DE QUE R5 SEA DISTINTO DE HIDROGENO EN 3 - AMINO - 1 BENCIL - PIRROLIDIN - 2,5 - DIONAS DE FORMULA (IVA)Y TRANSPOSICION A LA 3 - AMINO - 1 - BENCIL - PIRROLIDINA DE FORMULA (I) MEDIANTE REDUCCION COMPLETA DE LOS GRUPOS CARBONILO
ES198888115370T 1987-10-02 1988-09-20 Procedimiento para la obtencion de 3-amino-1-bencil piprolidinas. Expired - Lifetime ES2031974T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873733289 DE3733289A1 (de) 1987-10-02 1987-10-02 Verfahren zur herstellung von 3-amino-1-benzyl-pyrrolidinen

Publications (1)

Publication Number Publication Date
ES2031974T3 true ES2031974T3 (es) 1993-01-01

Family

ID=6337440

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888115370T Expired - Lifetime ES2031974T3 (es) 1987-10-02 1988-09-20 Procedimiento para la obtencion de 3-amino-1-bencil piprolidinas.

Country Status (8)

Country Link
US (1) US4910319A (es)
EP (1) EP0310854B1 (es)
JP (1) JP2505550B2 (es)
KR (1) KR970004595B1 (es)
AT (1) ATE76403T1 (es)
CA (1) CA1331623C (es)
DE (2) DE3733289A1 (es)
ES (1) ES2031974T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859776A (en) * 1988-03-11 1989-08-22 Abbott Laboratories (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation
JP2002284761A (ja) * 2001-01-17 2002-10-03 Toray Ind Inc 光学活性３−アミノピロリジン−２，５−ジオン誘導体および光学活性３−アミノピロリジン誘導体の製造方法
US7268236B2 (en) * 2002-03-29 2007-09-11 Kaneka Corporation Method of heightening optical purity of 1-benzyl-3-aminopyrrolidine and salt for used therein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433801A (en) * 1966-03-22 1969-03-18 Robins Co Inc A H 1-aryl-3-(n-lower alkyl amino) pyrrolidines
US3433802A (en) * 1968-06-25 1969-03-18 Robins Co Inc A H 3-(n-lower-alkylanilino)pyrrolidines
JPS593474B2 (ja) * 1976-08-25 1984-01-24 山之内製薬株式会社 ３−アミノ−１−ベンジルピロリジン誘導体の製法
JPS5522699A (en) * 1979-08-10 1980-02-18 Yamanouchi Pharmaceut Co Ltd Novel 3-amino-1-benzylpyrrolidine derivative

Also Published As

Publication number Publication date
EP0310854A1 (de) 1989-04-12
EP0310854B1 (de) 1992-05-20
US4910319A (en) 1990-03-20
KR890006583A (ko) 1989-06-14
ATE76403T1 (de) 1992-06-15
DE3871316D1 (de) 1992-06-25
KR970004595B1 (ko) 1997-03-29
CA1331623C (en) 1994-08-23
JP2505550B2 (ja) 1996-06-12
JPH01106862A (ja) 1989-04-24
DE3733289A1 (de) 1989-04-20

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