ES2037072T3 - Suspension coadyuvante estabilizada que comprende bromuro de dimetil-dioctadecil-amonio. - Google Patents

Suspension coadyuvante estabilizada que comprende bromuro de dimetil-dioctadecil-amonio.

Info

Publication number
ES2037072T3
ES2037072T3 ES198787202523T ES87202523T ES2037072T3 ES 2037072 T3 ES2037072 T3 ES 2037072T3 ES 198787202523 T ES198787202523 T ES 198787202523T ES 87202523 T ES87202523 T ES 87202523T ES 2037072 T3 ES2037072 T3 ES 2037072T3
Authority
ES
Spain
Prior art keywords
ammonium bromide
dioctadecil
coadjuvant
stabilized
suspension including
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787202523T
Other languages
English (en)
Inventor
Lucas Alfonsus Theodorus Hilgers
Marinus Wijnand Weststrate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of ES2037072T3 publication Critical patent/ES2037072T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Sorption Type Refrigeration Machines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UNA SUPENSION COADYUVANTE PARA VACUNAS QUE CONTIENE BROMURO DE DIMETILDIOCTADECILAMONIO (DDA) COMO COADYUVANTE Y UN POLIMERO DE ACIDO ACRILICO SOLUBLE EN AGUA (CARBAPOL) COMO AGENTE ESTABILIZADOR.
ES198787202523T 1986-12-19 1987-12-15 Suspension coadyuvante estabilizada que comprende bromuro de dimetil-dioctadecil-amonio. Expired - Lifetime ES2037072T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8603232 1986-12-19

Publications (1)

Publication Number Publication Date
ES2037072T3 true ES2037072T3 (es) 1993-06-16

Family

ID=19849021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787202523T Expired - Lifetime ES2037072T3 (es) 1986-12-19 1987-12-15 Suspension coadyuvante estabilizada que comprende bromuro de dimetil-dioctadecil-amonio.

Country Status (11)

Country Link
US (1) US5026546A (es)
EP (1) EP0273512B1 (es)
JP (1) JPS63165329A (es)
AT (1) ATE60999T1 (es)
DE (1) DE3768232D1 (es)
DK (1) DK661387A (es)
ES (1) ES2037072T3 (es)
GR (1) GR3001527T3 (es)
IE (1) IE60698B1 (es)
NZ (1) NZ222938A (es)
PT (1) PT86376B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432431B1 (en) * 1989-11-16 1993-06-16 PHIDEA S.p.A. Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient
NZ239643A (en) * 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5955077A (en) * 1993-07-02 1999-09-21 Statens Seruminstitut Tuberculosis vaccine
US6991797B2 (en) * 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
BE1008977A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US6982085B2 (en) * 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
US7037510B2 (en) 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
US20040013685A1 (en) * 1997-11-10 2004-01-22 Peter Andersen Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
FR2814957B1 (fr) * 2000-10-06 2002-12-20 Aventis Pasteur Composition vaccinale et procede de stabilisation
AP2005003238A0 (en) * 2002-08-26 2005-03-31 Pfizer Prod Inc Novel benzoimidazole derivatives useful as antiproliferative agents.
US6962608B1 (en) 2002-10-01 2005-11-08 The Regents Of The University Of California Regenerable antimicrobial polymers and fibers with oxygen bleaches
ES2391770T3 (es) 2003-01-21 2012-11-29 Novartis Vaccines And Diagnostics, Inc. Uso de compuestos de triptantrina para la potenciación inmune
US7893096B2 (en) 2003-03-28 2011-02-22 Novartis Vaccines And Diagnostics, Inc. Use of small molecule compounds for immunopotentiation
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
JP2008504292A (ja) 2004-06-24 2008-02-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 免疫増強用の化合物
US7749520B2 (en) * 2004-07-07 2010-07-06 Statens Serum Institut Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids
ITBO20050363A1 (it) * 2005-05-26 2006-11-27 Maccaferri Spa Off Elemento leggero di protezione filtro del tipo a materasso
WO2007109810A2 (en) * 2006-03-23 2007-09-27 Novartis Ag Methods for the preparation of imidazole-containing compounds
CA2646891A1 (en) * 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
CA2646539A1 (en) 2006-03-23 2007-09-27 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
CL2008001806A1 (es) * 2007-06-20 2008-09-05 Wyeth Corp Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion.
MX2010014026A (es) 2008-06-27 2011-02-15 Pfizer Composiciones adyuvantes novedosas.
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
KR101943171B1 (ko) 2013-09-19 2019-01-29 조에티스 서비시즈 엘엘씨 유성 아쥬반트
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
DK3244920T5 (da) 2015-01-16 2024-10-07 Zoetis Services Llc Mund- og klovsyge-vaccine
TW202015725A (zh) 2018-06-04 2020-05-01 美商亞博創新醫藥有限公司 Tlr7 肽結合物
KR20210027381A (ko) 2018-07-02 2021-03-10 아유비스 리서치, 인코포레이티드 신규 면역조절 소분자

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919411A (en) * 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant

Also Published As

Publication number Publication date
DK661387A (da) 1988-06-20
ATE60999T1 (de) 1991-03-15
PT86376B (pt) 1990-11-20
US5026546A (en) 1991-06-25
DK661387D0 (da) 1987-12-16
JPS63165329A (ja) 1988-07-08
IE60698B1 (en) 1994-08-10
EP0273512A2 (en) 1988-07-06
NZ222938A (en) 1990-11-27
GR3001527T3 (en) 1992-11-23
IE873407L (en) 1988-06-19
PT86376A (en) 1988-01-01
EP0273512A3 (en) 1988-07-27
DE3768232D1 (de) 1991-04-04
EP0273512B1 (en) 1991-02-27

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