ES2037082T3 - Una composicion para la liberacion controlada de un farmaco. - Google Patents

Una composicion para la liberacion controlada de un farmaco.

Info

Publication number
ES2037082T3
ES2037082T3 ES198787305625T ES87305625T ES2037082T3 ES 2037082 T3 ES2037082 T3 ES 2037082T3 ES 198787305625 T ES198787305625 T ES 198787305625T ES 87305625 T ES87305625 T ES 87305625T ES 2037082 T3 ES2037082 T3 ES 2037082T3
Authority
ES
Spain
Prior art keywords
fluids
pharmaceutical compound
controlled release
body fluids
microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787305625T
Other languages
English (en)
Inventor
John Weldon Shell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iolab Inc
Original Assignee
Iolab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iolab Inc filed Critical Iolab Inc
Application granted granted Critical
Publication of ES2037082T3 publication Critical patent/ES2037082T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UNA COMPOSICION DE DOSIFICACION PARA LIBERACION CONTROLADA DE UN COMPUESTO FARMACEUTICO A FLUIDOS DE PERSONAS, TALES COMO LAS LAGRIMAS DEL OJO, O FLUIDOS DE PUNTOS QUIRURGICOS, TIENE UNA MATRIZ EXTERNA RAPIDAMENTE SOLUBLE EN DICHOS FLUIDOS, Y MICROPARTICULAS BIODESTRUIBLES DISPERSAS EN LA MATRIZ EXTERNA, CONTENIENDO LAS MICROPARTICULAS EL COMPUESTO FARMACEUTICO, Y SIENDO CAPACES DE LIBERARLO GRADUALMENTE Y EN FORMA CONTROLADA A LOS FLUIDOS HUMANOS, Y SIENDO DE UN TAMAÑO QUE SE CONSERVA DURANTE UN PERIODO DE TIEMPO SUFICIENTEMENTE LARGO PARA PROPORCIONAR UNA DOSIS EFECTIVA DEL COMPUESTO FARMACEUTICO AL SITIO DE COLOCACION DURANTE UN PERIODO DE TIEMPO AMPLIO. LAS MICROPARTICULAS AL FINAL SE DISUELVEN EN LOS FLUIDOS HUMANOS.
ES198787305625T 1986-06-25 1987-06-24 Una composicion para la liberacion controlada de un farmaco. Expired - Lifetime ES2037082T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87827286A 1986-06-25 1986-06-25

Publications (1)

Publication Number Publication Date
ES2037082T3 true ES2037082T3 (es) 1993-06-16

Family

ID=25371703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787305625T Expired - Lifetime ES2037082T3 (es) 1986-06-25 1987-06-24 Una composicion para la liberacion controlada de un farmaco.

Country Status (8)

Country Link
EP (1) EP0251680B1 (es)
JP (1) JPS6322516A (es)
AT (1) ATE74752T1 (es)
AU (1) AU606872B2 (es)
CA (1) CA1311686C (es)
DE (1) DE3778223D1 (es)
ES (1) ES2037082T3 (es)
GR (1) GR3004710T3 (es)

Families Citing this family (55)

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US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
US5082667A (en) * 1988-06-07 1992-01-21 Abbott Laboratories Solid pharmaceutical dosage in tablet triturate form and method of producing same
ES2057021T3 (es) * 1988-06-07 1994-10-16 Abbott Lab Un metodo de manufactura de una dosificacion farmaceutica solida en forma de triturado en tableta.
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
GB8917217D0 (en) * 1989-07-27 1989-09-13 Smith & Nephew Ophthalmic compositions
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
JP3011752B2 (ja) * 1990-10-23 2000-02-21 フロイント産業株式会社 徐放性製剤およびその製造方法
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
JPH08507747A (ja) * 1992-12-30 1996-08-20 クローバー コンソリデイテッド，リミテッド 生物学的活性物質用の細包を保護し生体に適合する、再利用可能なマクロカプセル封入システム
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
WO1997007788A2 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
DE19756314C2 (de) * 1997-12-12 2000-06-29 Roland Bodmeier Zubereitung mit verlängerter Verweildauer am Applikationsort
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
DE10133870A1 (de) * 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
JP2005525299A (ja) * 2001-09-14 2005-08-25 スコラー インコーポレイテッド アミノ酸調節性の長期放出投薬形態
DE10246900A1 (de) 2002-10-08 2004-04-22 Horstmann, Michael, Dr. Am Auge applizierbare Vorrichtung zur sicheren Dosierung systemischer und tropischer Medikation
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
ES2669585T3 (es) 2004-10-29 2018-05-28 The Regents Of The University Of California Micropartículas porosas de silicio para la entrega de fármaco para el ojo
JP2006257080A (ja) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd ステロイド化合物の副作用軽減または回避方法
EP2319558B1 (en) 2006-03-14 2014-05-21 University Of Southern California Mems device for delivery of therapeutic agents
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
JP2009542671A (ja) * 2006-06-28 2009-12-03 サーモディクス，インコーポレイティド 微粒子を含む活性剤溶出マトリックス
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
CA2704111C (en) * 2007-05-14 2017-06-20 Sustained Nano Systems Llc Hypercompressed particles for controlled release of ophthalmic medications
JP5542691B2 (ja) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア 治療薬を送達するための装置および方法
ES2577502T3 (es) 2008-01-03 2016-07-15 University Of Southern California Dispositivos implantables de administración de fármacos y aparato para recargar los dispositivos
CN102202706A (zh) 2008-05-08 2011-09-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
EP2320989B1 (en) 2008-05-08 2015-03-11 MiniPumps, LLC Implantable pumps and cannulas therefor
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
US8231608B2 (en) 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US9498431B2 (en) 2008-12-10 2016-11-22 Jianjian Xu Controlled releasing composition
USD629503S1 (en) 2009-05-08 2010-12-21 Sean Caffey Implantable drug-delivery pump
EP2437684B1 (en) * 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
JP5758388B2 (ja) 2009-08-18 2015-08-05 ミニパンプス， エルエルシー 適応制御を有する電解質薬物送達ポンプ
US8469934B2 (en) 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
JP2012025708A (ja) * 2010-07-27 2012-02-09 Sepa Sigma Inc 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
MX2013008993A (es) 2013-08-02 2014-03-24 Raam De Sahuayo S A De C V Lab Sistema de liberacion modificada en tres fases de un antiinflamatorio no esteroide.
PT3062775T (pt) 2013-10-31 2018-03-06 Allergan Inc Implantes intraoculares contendo prostamida e métodos para a sua utilização
EP3302382A4 (en) * 2015-05-29 2019-02-20 Allergan, Inc. IMPLANT FOR THE TREATMENT OF OCULAR DISEASE
EP3108874A1 (en) * 2015-06-26 2016-12-28 TRB Chemedica AG Ophthalmologic pharmaceutical composition
CN111050754A (zh) * 2017-07-17 2020-04-21 商福溪生技有限公司 用于递送活性剂的微粒制剂
CN115554460A (zh) * 2022-09-26 2023-01-03 山东万容生物科技有限公司 一种多功能湿性敷料及其制备方法
CN119950174B (zh) * 2025-02-20 2025-11-21 中国人民解放军陆军军医大学第一附属医院 一种可分步浸润液体的眼部护理亲水贴片装置

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US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
BE788575A (fr) * 1971-09-09 1973-01-02 Alza Corp Dispositif oculaire pour l'administration d'un
US4179497A (en) * 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
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IE50901B1 (en) * 1980-03-04 1986-08-06 Merck & Co Inc Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation

Also Published As

Publication number Publication date
EP0251680B1 (en) 1992-04-15
ATE74752T1 (de) 1992-05-15
EP0251680A3 (en) 1988-02-24
DE3778223D1 (de) 1992-05-21
GR3004710T3 (es) 1993-04-28
CA1311686C (en) 1992-12-22
AU7465087A (en) 1988-01-07
EP0251680A2 (en) 1988-01-07
AU606872B2 (en) 1991-02-21
JPS6322516A (ja) 1988-01-30

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