ES2037660T3 - Procedimiento para preparar derivados de imidazopiridina condensados. - Google Patents

Procedimiento para preparar derivados de imidazopiridina condensados.

Info

Publication number
ES2037660T3
ES2037660T3 ES198686308087T ES86308087T ES2037660T3 ES 2037660 T3 ES2037660 T3 ES 2037660T3 ES 198686308087 T ES198686308087 T ES 198686308087T ES 86308087 T ES86308087 T ES 86308087T ES 2037660 T3 ES2037660 T3 ES 2037660T3
Authority
ES
Spain
Prior art keywords
radical
alkylic
halogen
alkyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686308087T
Other languages
English (en)
Inventor
Susumu Takada
Toshio Fujishita
Takashi Sasatani
Akira Matsushita
Masami Eigyo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2037660T3 publication Critical patent/ES2037660T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

DONDE R ES UN GRUPO FENILO CON UNO O DOS SUSTITUYENTES DE ENTRE LOS SIGUIENTES: TRIFLUOROMETIL, RADICAL ALQUILICO C1-5, RADICAL ALCOXILICO C1-5, RADICAL TIOALPULICO C1-5, NITRO, RADICAL AMINO ALPULICO C1-5 Y RADICAL ALCOXICARBONIL C1-5 O UN GRUPO HETEROCICLICO DE 5 O 6 MIEMBROS OPCIONALMENTE SUSTITUIDO POR UNO DE LOS SIGUIENTES GRUPOS: HALOGENO, RADICAL ALQUILICO C1-5 Y RADICAL ALCOXILICO C1-5, Q: ES H, RADICAL ALQUILICO C1-5, RADICAL ACICLICO C1-10, RADICAL SULFONIALQUILICO C1-5 O RADICAL SULFONILARILO C5-10. R1, R2, R3 Y R4 SON H, HALOGENO, ALQUILICO C1-C5 O ALQUILHALOGENO C1-C5. Q ESTA UNIDO AL N DE LAS POSICIONES 1,3 O 5 Y LA LINEA DE PUNTOS INDICA LA PRESENCIA DE TRES DOBLES ENLACES EN LA POSICION 2,3; 3A,3B; 4,5; 1,3B; 2,3; 3A,4 O 1,2; 3A,3B; 4,5. ESTOS COMPUESTOS Y SUS SALES SON UTILES COMO PSICOESTIMULANTES O ANXIOLITICOS.
ES198686308087T 1985-10-18 1986-10-17 Procedimiento para preparar derivados de imidazopiridina condensados. Expired - Lifetime ES2037660T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23435785 1985-10-18
JP11968186 1986-05-23

Publications (1)

Publication Number Publication Date
ES2037660T3 true ES2037660T3 (es) 1993-07-01

Family

ID=26457370

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686308087T Expired - Lifetime ES2037660T3 (es) 1985-10-18 1986-10-17 Procedimiento para preparar derivados de imidazopiridina condensados.

Country Status (8)

Country Link
US (1) US4753951A (es)
EP (1) EP0223420B1 (es)
KR (1) KR910001136B1 (es)
AU (1) AU599340B2 (es)
CA (1) CA1306260C (es)
DE (1) DE3677711D1 (es)
ES (1) ES2037660T3 (es)
GB (1) GB2182930B (es)

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US5003103A (en) * 1989-11-20 1991-03-26 Occidental Chemical Corporation Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-difluorophthalic anhydride of 4,5-difluorophthalic acid
WO1993012116A1 (en) * 1991-12-12 1993-06-24 Kyowa Hakko Kogyo Co., Ltd. Thienoimidazopyridone derivative
US5378848A (en) * 1992-02-12 1995-01-03 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
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CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
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WO2005018556A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
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US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
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WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
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AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
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WO2006009832A1 (en) * 2004-06-18 2006-01-26 3M Innovative Properties Company Substituted imidazo ring systems and methods
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WO2006032851A1 (en) * 2004-09-20 2006-03-30 Biolipox Ab Pyrazole compounds useful in the treatment of inflammation
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AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
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CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
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TW200800911A (en) * 2005-10-20 2008-01-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
AU2006310367A1 (en) * 2005-10-31 2007-05-10 Biolipox Ab Triazole compounds as lipoxygenase inhibitors
TW200732320A (en) * 2005-10-31 2007-09-01 Biolipox Ab Pyrazoles useful in the treatment of inflammation
US20090088463A1 (en) * 2005-11-01 2009-04-02 Benjamin Pelcman Pyrazoles Useful in the Treatment of Inflammation
HUE028588T2 (hu) 2005-12-13 2016-12-28 Incyte Holdings Corp Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
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CA2792508C (en) 2010-03-10 2018-01-16 Incyte Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
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US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
US8691807B2 (en) 2011-06-20 2014-04-08 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CA2888816A1 (en) 2012-11-01 2014-05-08 Incyte Corporation Tricyclic fused thiophene derivatives as jak inhibitors
KR102242077B1 (ko) 2012-11-15 2021-04-20 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
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TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
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Also Published As

Publication number Publication date
GB2182930A (en) 1987-05-28
GB2182930B (en) 1989-09-27
EP0223420A1 (en) 1987-05-27
AU599340B2 (en) 1990-07-19
EP0223420B1 (en) 1991-02-27
US4753951A (en) 1988-06-28
KR910001136B1 (ko) 1991-02-25
CA1306260C (en) 1992-08-11
DE3677711D1 (de) 1991-04-04
GB8624939D0 (en) 1986-11-19
AU6416586A (en) 1987-04-30
KR870004030A (ko) 1987-05-07

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