ES2038344T3 - Soluciones concentradas de corticoesteroides y metodo para su fabricacion. - Google Patents

Soluciones concentradas de corticoesteroides y metodo para su fabricacion.

Info

Publication number
ES2038344T3
ES2038344T3 ES198989100413T ES89100413T ES2038344T3 ES 2038344 T3 ES2038344 T3 ES 2038344T3 ES 198989100413 T ES198989100413 T ES 198989100413T ES 89100413 T ES89100413 T ES 89100413T ES 2038344 T3 ES2038344 T3 ES 2038344T3
Authority
ES
Spain
Prior art keywords
surfactant
corticosteroid
solution
temperature
pour point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198989100413T
Other languages
English (en)
Inventor
Donna K. Cno Schwarz Parma-Kremers Multhauf
Sudhakar S. Dr. Cno Schwarz Parma-Kremers Wagle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
Schwarz Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schwarz Pharma AG filed Critical Schwarz Pharma AG
Application granted granted Critical
Publication of ES2038344T3 publication Critical patent/ES2038344T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

UNA DISOLUCION DE UN CORTICOSTEROIDE COMPRENDE: AL MENOS UNOS 2,5% DEL CORTICOSTEROIDE; DE UNOS 25% A UNOS 80% DE UN AGENTE SUPERFICIATIVO; DE UNOS 0 A UNOS 70% DE ETANOL; DE 0 A UNOS 70% DE PROPILENO GLICOL; ESTA PREVISTO QUE LA CANTIDAD DE ETANOL O DE PROPILENO GLICOL O DE LOS DOS JUNTOS ES DE AL MENOS UNOS 15%; UNA CANTIDAD EFECTIVA DE UN AGENTE ANTIMICROBIAL; Y DE RESTO AGUA. TAMBIEN UN METODO DE PREPARACION DE ESTA DISOLUCION COMPENDE: MEZCLAR EL AGENTE SUPERFICIATIVO Y EL CORTICOSTEROIDE AL CALOR HASTA QUE LA TEMPERATURA ESTA DE 5 A 10 C SOBRE EL PUNTO DE CONGELACION DEL AGENTE SUPERFICIATIVO; MEZCLAR SEPARADAMETNE LOS INGREDIENTES RESTANTES AL CALOR HASTA QUE LA TEMPERATURA ESTE ENTRE 5 Y 10 C SOBRE EL PUNTO DE CONGELACION DEL AGENTE SUPERFICIATIVO CON LA MEZCLA HASTA QUE UNA DISOLUCION ES FORMADA.
ES198989100413T 1988-01-13 1989-01-11 Soluciones concentradas de corticoesteroides y metodo para su fabricacion. Expired - Lifetime ES2038344T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14357988A 1988-01-13 1988-01-13

Publications (1)

Publication Number Publication Date
ES2038344T3 true ES2038344T3 (es) 1993-07-16

Family

ID=22504674

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198989100413T Expired - Lifetime ES2038344T3 (es) 1988-01-13 1989-01-11 Soluciones concentradas de corticoesteroides y metodo para su fabricacion.

Country Status (5)

Country Link
EP (1) EP0325949B1 (es)
AT (1) ATE70446T1 (es)
DE (1) DE68900548D1 (es)
ES (1) ES2038344T3 (es)
GR (1) GR3003623T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6005001A (en) * 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
FR2761600B1 (fr) * 1998-06-19 2000-03-31 Oreal Composition moussante pour le lavage et le traitement des cheveux et/ou du cuir chevelu a base d'un principe actif, d'un tensioactif anionique, d'un tensioactif amphotere et d'un agent propenetrant
US7244703B2 (en) 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
JP2007513199A (ja) 2003-12-08 2007-05-24 ベントレー ファーマスーティカルス，インコーポレイテッド インスリン治療のための薬学的組成物及び方法
FR2911781B1 (fr) 2007-01-26 2009-03-20 Fabre Pierre Dermo Cosmetique Emulsion dermatologique et procede de preparation
EP2709632A4 (en) * 2011-05-16 2015-03-04 Dale L Pearlman COMPOSITIONS AND METHOD FOR THE TREATMENT OF SKIN DISEASES
US9861645B2 (en) 2012-12-28 2018-01-09 Rak Holdings Llc Anti-itch scalp treatment compositions and combinations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3900561A (en) * 1970-12-17 1975-08-19 Glaxo Lab Ltd Pharmaceutical compositions
US4360518A (en) * 1979-08-06 1982-11-23 Johnson & Johnson Topical anti-inflammatory drug therapy
US4863912A (en) * 1986-05-19 1989-09-05 New York Medical College Use of tetrahydrocortisol in glaucoma therapy

Also Published As

Publication number Publication date
DE68900548D1 (de) 1992-01-30
ATE70446T1 (de) 1992-01-15
EP0325949B1 (en) 1991-12-18
EP0325949A1 (en) 1989-08-02
GR3003623T3 (es) 1993-03-16

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