ES2038692T3 - Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos. - Google Patents

Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos.

Info

Publication number
ES2038692T3
ES2038692T3 ES198787810664T ES87810664T ES2038692T3 ES 2038692 T3 ES2038692 T3 ES 2038692T3 ES 198787810664 T ES198787810664 T ES 198787810664T ES 87810664 T ES87810664 T ES 87810664T ES 2038692 T3 ES2038692 T3 ES 2038692T3
Authority
ES
Spain
Prior art keywords
acids
alcanodiphosphonic
procedure
obtaining substituted
phosphonic group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787810664T
Other languages
English (en)
Other versions
ES2038692T4 (es
Inventor
Knut A. Dr. Jaeggi
Leo Dr. Widler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4280350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2038692(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2038692T3 publication Critical patent/ES2038692T3/es
Anticipated expiration legal-status Critical
Publication of ES2038692T4 publication Critical patent/ES2038692T4/es
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Control Of El Displays (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS ACIDOS ALCANODIFOSFONICOS, EN PARTICULAR, ACIDOS HETEROARILALCANODIFOSFONICOS DE FORMULA (I), DONDE R1, REPRESENTA LOS GRUPOS INDICADOS EN LA DESCRIPCION, Y R2 ES HIDROGENO, HIDROXILO, AMINO, TIOALQUILO INFERIOR O HALOGENO, Y SUS SALES POSEEN PROPIEDADES REGULADORAS DEL METABOLISMO DEL CALCIO Y PUEDEN EMPLEARSE COMO MEDICAMENTOS PARA EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON ALTERACIONES DEL METABOLISMO DEL CALCIO. SE OBTIENEN, POR EJEMPLO, A PARTIR DE UN COMPUESTO DE FORMULA (II) DONDE X1 REPRESENTA UN GRUPO FOSFONICO FUNCIONALMENTE MODIFICADO Y X2 REPRESENTA UN GRUPO FOSFONICO LIBRE O FUNCIONALMENTE MODIFICADO. EN DICHO COMPUESTO SE CONVIERTE X1, Y EN SU CASO, X2, EN EL GRUPO FOSFONICO LIBRE.
ES87810664T 1986-11-21 1987-11-16 Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos. Expired - Lifetime ES2038692T4 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH466686 1986-11-21
CH4666/86 1986-11-21

Publications (2)

Publication Number Publication Date
ES2038692T3 true ES2038692T3 (es) 1993-08-01
ES2038692T4 ES2038692T4 (es) 2012-02-10

Family

ID=4280350

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87810664T Expired - Lifetime ES2038692T4 (es) 1986-11-21 1987-11-16 Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos.

Country Status (27)

Country Link
US (1) US4939130A (es)
EP (1) EP0275821B1 (es)
JP (1) JP2744238B2 (es)
KR (1) KR960010752B1 (es)
AT (1) ATE72816T1 (es)
AU (1) AU607722B2 (es)
CA (1) CA1338937C (es)
CY (1) CY1827A (es)
DD (1) DD270533A5 (es)
DE (2) DE3776880D1 (es)
DK (1) DK174098B1 (es)
ES (1) ES2038692T4 (es)
FI (1) FI87570C (es)
GR (1) GR3003895T3 (es)
HK (1) HK114894A (es)
HU (1) HU199150B (es)
IE (1) IE59816B1 (es)
IL (1) IL84497A (es)
LU (1) LU90838I2 (es)
MX (1) MX9427A (es)
NL (1) NL300058I2 (es)
NO (2) NO173446C (es)
NZ (1) NZ222610A (es)
PH (1) PH24345A (es)
PT (1) PT86167B (es)
SG (1) SG92194G (es)
ZA (1) ZA878698B (es)

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HUT46330A (en) 1988-10-28
EP0275821A1 (de) 1988-07-27
DE3776880D1 (de) 1992-04-02
NO874856D0 (no) 1987-11-20
AU607722B2 (en) 1991-03-14
NO173446B (no) 1993-09-06
NO173446C (no) 1993-12-15
DK609587D0 (da) 1987-11-20
MX9427A (es) 1993-12-01
FI87570B (fi) 1992-10-15
EP0275821B1 (de) 1992-02-26
HU199150B (en) 1990-01-29
IL84497A (en) 1994-10-21
ATE72816T1 (de) 1992-03-15
NO874856L (no) 1988-05-24
NZ222610A (en) 1990-09-26
FI875096A7 (fi) 1988-05-22
CY1827A (en) 1995-12-01
KR960010752B1 (ko) 1996-08-08
DK609587A (da) 1988-05-22
IL84497A0 (en) 1988-04-29
NL300058I2 (nl) 2002-02-01
FI875096A0 (fi) 1987-11-18
DK174098B1 (da) 2002-06-17
NO2001015I2 (no) 2004-10-11
JPS63150291A (ja) 1988-06-22
ZA878698B (en) 1988-05-23
FI87570C (fi) 1993-01-25
AU8145387A (en) 1988-05-26
PT86167B (pt) 1990-08-31
DD270533A5 (de) 1989-08-02
PT86167A (en) 1987-12-01
DE10199052I1 (de) 2002-01-10
IE873148L (en) 1988-05-21
GR3003895T3 (es) 1993-03-16
ES2038692T4 (es) 2012-02-10
JP2744238B2 (ja) 1998-04-28
IE59816B1 (en) 1994-04-06
KR880006204A (ko) 1988-07-22
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PH24345A (en) 1990-06-13
LU90838I2 (fr) 2001-11-19
CA1338937C (en) 1997-02-25
NL300058I1 (nl) 2001-12-01
SG92194G (en) 1995-04-28
US4939130A (en) 1990-07-03

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