ES2038693T3 - Nuevos acidos aminometanodifosfonicos substituidos. - Google Patents

Nuevos acidos aminometanodifosfonicos substituidos.

Info

Publication number
ES2038693T3
ES2038693T3 ES198787810665T ES87810665T ES2038693T3 ES 2038693 T3 ES2038693 T3 ES 2038693T3 ES 198787810665 T ES198787810665 T ES 198787810665T ES 87810665 T ES87810665 T ES 87810665T ES 2038693 T3 ES2038693 T3 ES 2038693T3
Authority
ES
Spain
Prior art keywords
phosphone
group
substituted
atom
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787810665T
Other languages
English (en)
Inventor
Leo Dr. Widler
Knut A. Dr. Jaeggi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2038693T3 publication Critical patent/ES2038693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/65392—Five-membered rings containing two nitrogen atoms
    • C07F9/65397—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

ACIDOS HETEROARILAMINOMETANDIFOSFONICOS DE FORMULA (I) DONDE R1 ES UN FENILO NO SUSTITUIDO O SUSTIUIDO POR ALQUILO INFERIOR, ALCOXI INFERIOR Y/O HALOGENO, UN ANILLO DE 5 MIEMBROS SUSTITUIDO CON ALCOXI INFERIOR, HIDROXI, DIALQUILAMINO INFERIOR, ALQUILTIO INFERIOR Y/O HALOGENO, SI ES CASO BENZO- O CICLOHEXENOCONDENSADO, COMO HETEROATOMO(S) 2 A 4 ATOMOS DE N O UN RESTO HETEROARILO QUE PRESENTA 1 O 2 ATOMOS DE N ASI COMO UN ATOMO DE 0 O 1 ATOMO DE S, Y R2 SIGNIFICA HIDROGENO O ALQUILO INFERIOR, Y SUS SALES ACTUAN REGULANDO EL METABOLISMO DEL CALCIO Y PUEDEN APLICARSE COMO MEDICAMENTOS PARA EL TRATAMIENTO DE LAS ENFERMEDADES DERIVADAS DE ESE PROCESO ALTERADO. PUEDEN OBTENERSE COMO COMPUESTOS DE LA FORMULA (II), DONDE X1 ES UN GRUPO FOSFONICO X MODIFICADO FUNCIONAL Y X2 ES UN GRUPO FOSFONO O UN GRUPO FOSFONO X MODIFICADO FUNCIONAL QUE TRANSFORMA EL GRUPO(S) X A FOSFONO LIBRE.
ES198787810665T 1986-11-21 1987-11-16 Nuevos acidos aminometanodifosfonicos substituidos. Expired - Lifetime ES2038693T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH466586 1986-11-21

Publications (1)

Publication Number Publication Date
ES2038693T3 true ES2038693T3 (es) 1993-08-01

Family

ID=4280333

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787810665T Expired - Lifetime ES2038693T3 (es) 1986-11-21 1987-11-16 Nuevos acidos aminometanodifosfonicos substituidos.

Country Status (21)

Country Link
EP (1) EP0274346B1 (es)
JP (1) JPS63150290A (es)
KR (1) KR880006217A (es)
AT (1) ATE61371T1 (es)
AU (1) AU605203B2 (es)
CA (1) CA1324383C (es)
DD (1) DD265900A5 (es)
DE (1) DE3768463D1 (es)
DK (1) DK168869B1 (es)
ES (1) ES2038693T3 (es)
FI (1) FI87653C (es)
GR (1) GR3001611T3 (es)
HU (1) HU201087B (es)
IE (1) IE60148B1 (es)
IL (1) IL84494A (es)
MY (1) MY103191A (es)
NO (1) NO170283C (es)
NZ (1) NZ222608A (es)
PH (1) PH23959A (es)
PT (1) PT86166B (es)
ZA (1) ZA878656B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880011136A (ko) * 1987-03-11 1988-10-26 모리오까 시게오 아졸- 아미노메틸렌 비스포스폰산 유도체
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
TW237386B (es) * 1992-04-15 1995-01-01 Ciba Geigy
EP0600834A1 (en) * 1992-11-30 1994-06-08 Ciba-Geigy Ag Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
ATE290871T1 (de) * 1995-09-29 2005-04-15 Novartis Pharma Gmbh Verfahren zur behandlung navikularer krankheiten bei pferden
DE10226420A1 (de) * 2002-06-13 2004-01-15 Eucro European Contract Research Gmbh & Co Kg Verfahren zur Behandlung der Artherosklerose

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54135724A (en) * 1978-04-11 1979-10-22 Nissan Chem Ind Ltd Preparation of amino-methylenedisulfonic acid derivative
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds

Also Published As

Publication number Publication date
DK609387A (da) 1988-05-22
AU8145287A (en) 1988-05-26
NO874855L (no) 1988-05-24
NO170283C (no) 1992-09-30
KR880006217A (ko) 1988-07-22
PH23959A (en) 1990-01-23
GR3001611T3 (en) 1992-11-23
FI87653C (fi) 1993-02-10
FI875095A0 (fi) 1987-11-18
IE873147L (en) 1988-05-21
DE3768463D1 (de) 1991-04-11
IL84494A (en) 1992-08-18
DK609387D0 (da) 1987-11-20
ATE61371T1 (de) 1991-03-15
FI87653B (fi) 1992-10-30
ZA878656B (en) 1988-08-31
EP0274346A1 (de) 1988-07-13
FI875095A7 (fi) 1988-05-22
NO170283B (no) 1992-06-22
IE60148B1 (en) 1994-06-01
MY103191A (en) 1993-05-29
CA1324383C (en) 1993-11-16
PT86166B (pt) 1990-11-20
JPS63150290A (ja) 1988-06-22
NO874855D0 (no) 1987-11-20
PT86166A (en) 1987-12-01
DK168869B1 (da) 1994-06-27
IL84494A0 (en) 1988-04-29
HUT46329A (en) 1988-10-28
EP0274346B1 (de) 1991-03-06
HU201087B (en) 1990-09-28
NZ222608A (en) 1990-09-26
AU605203B2 (en) 1991-01-10
DD265900A5 (de) 1989-03-15

Similar Documents

Publication Publication Date Title
ES2038622T3 (es) Utilizacion de un derivado de naftaleno y su procedimiento de preparacion.
ES2078324T3 (es) Pteridina-4 (3h)-onas, procedimientos de preparacion y medicamentos que los contienen.
ES388135A2 (es) Procedimiento para la obtencion de lactamas sustituidas en el nitrogeno.
ES2056962T3 (es) Un procedimiento para la preparacion de nuevos derivados de camptotecina.
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
AR004195A1 (es) Nuevos derivados de la 5-0 desosaminil-6-0-metil-eritronolida a, su procedimiento de preparacion, compuestos intermediarios, metodo de aplicacionde los mismos para la preparacion de productos biologicamente activos.
ES2062974T3 (es) Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos.
SE9100342D0 (sv) Novel steroid esters
ES2093399T3 (es) Nuevos derivados de acido fosfono-succinico, procedimiento para su preparacion y medicamentos que contienen estos compuestos.
MX168918B (es) Proceso para preparar compuestos de quinolona
FR2357556A1 (fr) Procede de transformation de cis-hexahydrodibenzo(b,d) pyran-9-ones en trans-hexahydrodibenzo(b,d) pyran-9-ones
MX165348B (es) Composicion inhibidora de polimerizacion para compuestos vinilaromaticos
ES2038693T3 (es) Nuevos acidos aminometanodifosfonicos substituidos.
AR029165A1 (es) Compuestos de nitrilo de acido arilmalonico sustituido y proceso para su preparacion
ES2130736T3 (es) Derivados del pirrolilbencimidazol.
ES8706148A1 (es) Un procedimiento para preparar nuevos derivados de carbapenem.
ES2095848T3 (es) Nuevos derivados de fosfolipidos y su utilizacion para la preparacion de medicamentos antiviricos.
ES2038776T3 (es) Procedimiento de preparacion de derivados de la oxima del 1,2,5,6-tetrahidropiridin-3-carboxaldehido.
ATE114468T1 (de) Ethyl-(+)-apovincaminat zur behandlung der demyelinisierung klinischer erscheinungen autoimmunen ursprungs.
ES2051805T3 (es) Un proceso para la produccion de oxidos de benzoxazinil-triazol.
ES483214A1 (es) Un procedimiento para la preparacion de compuestos derivadosde morfolina y piperidina
DK439082A (da) 4-acylamino-1-aza-adamantan-forbindelser samt fremgangsmaade til fremstilling deraf
ES2045282T3 (es) Un procedimiento para la preparacion de antraciclinona 4-sustituida.
ES2038194T3 (es) Procedimiento para la obtencion de derivados de la benzhidriloxietil-piperidina.
ES2041755T3 (es) Procedimiento para la preparacion de nuevas tiadiacinas, e insecticidas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 274346

Country of ref document: ES