ES2043617T3 - Un procedimiento para preparar derviados de benzamida. - Google Patents

Un procedimiento para preparar derviados de benzamida.

Info

Publication number
ES2043617T3
ES2043617T3 ES87106266T ES87106266T ES2043617T3 ES 2043617 T3 ES2043617 T3 ES 2043617T3 ES 87106266 T ES87106266 T ES 87106266T ES 87106266 T ES87106266 T ES 87106266T ES 2043617 T3 ES2043617 T3 ES 2043617T3
Authority
ES
Spain
Prior art keywords
procedure
benzamide derivatives
salts
compounds
preparing benzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87106266T
Other languages
English (en)
Spanish (es)
Inventor
Tatsuya Kon
Shiro Kato
Toshiya Morie
Kazunori Ohno
Katsuhiko Hino
Tadahiko Karasawa
Naoyuki Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2043617T3 publication Critical patent/ES2043617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
ES87106266T 1986-04-30 1987-04-29 Un procedimiento para preparar derviados de benzamida. Expired - Lifetime ES2043617T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10155286 1986-04-30
JP31509086 1986-12-31

Publications (1)

Publication Number Publication Date
ES2043617T3 true ES2043617T3 (es) 1994-01-01

Family

ID=26442419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87106266T Expired - Lifetime ES2043617T3 (es) 1986-04-30 1987-04-29 Un procedimiento para preparar derviados de benzamida.

Country Status (18)

Country Link
US (1) US4870074A (2)
EP (1) EP0243959B1 (2)
KR (1) KR870010030A (2)
AR (1) AR242953A1 (2)
AU (1) AU592177B2 (2)
CA (1) CA1291135C (2)
CZ (1) CZ284687B6 (2)
DE (1) DE3781195T2 (2)
DK (1) DK175281B1 (2)
ES (1) ES2043617T3 (2)
FI (1) FI87776C (2)
GR (1) GR3005934T3 (2)
HK (1) HK18194A (2)
HU (1) HU198193B (2)
NZ (1) NZ220120A (2)
PH (1) PH24049A (2)
SK (1) SK289787A3 (2)
SU (1) SU1597101A3 (2)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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FR2640139A1 (fr) * 1988-12-14 1990-06-15 Delagrange Laboratoires Application de benzamides substitues comme gastromoteurs
TW243449B (2) * 1991-02-15 1995-03-21 Hokuriku Pharmaceutical
US5395832A (en) * 1991-02-15 1995-03-07 Hokuriku Seiyaku Co., Ltd. Benzamide derivatives
EP0774460A1 (en) * 1994-03-30 1997-05-21 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compound and use thereof as medicine
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
ES2167563T3 (es) * 1995-05-23 2002-05-16 Janssen Pharmaceutica Nv Derivados de (2-morfolinilmetil)benzamida.
JP2001064177A (ja) * 1999-08-16 2001-03-13 Schering Ag ベンズアミド誘導体を有効成分とする製剤
IL155093A0 (en) 2000-09-29 2003-10-31 Glaxo Group Ltd Morpholin-acetamide derivatives for the treatment on inflammatory diseases
EP1353918B1 (en) * 2000-11-28 2005-01-12 Smithkline Beecham Plc Morpholine derivatives as antagonists of orexin receptors
JP4829417B2 (ja) * 2001-03-26 2011-12-07 明夫 乾 インスリン抵抗性改善薬
AU2002356418A1 (en) * 2001-10-08 2003-04-22 Sun Pharmaceutical Industries Limited An antispasmodic agent spaced drug delivery system
GB0207447D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207449D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0208158D0 (en) * 2002-03-28 2002-05-22 Glaxo Group Ltd Novel compounds
HUP0201980A3 (en) * 2002-06-13 2008-06-30 Richter Gedeon Nyrt Process for preparing a benzamide derivative and intermediates thereof
CN1913876B (zh) * 2003-12-09 2013-06-26 大日本住友制药株式会社 含药物的颗粒和包含这种颗粒的固体制剂
PT1704146E (pt) 2004-01-07 2010-06-30 Aryx Therapeutics Inc Compostos estereoisoméricos e processos para o tratamento de distúrbios gastrointestinais e do sistema nervoso central
US8138204B2 (en) * 2004-01-07 2012-03-20 Aryx Therapeutics, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8524736B2 (en) 2004-01-07 2013-09-03 Armetheon, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
TW200619212A (en) * 2004-09-08 2006-06-16 Mitsubishi Pharma Corp Morpholine derivatives
CN101248060B (zh) * 2005-06-23 2014-09-10 阵列生物制药公司 用于制备苯并咪唑化合物的方法
KR101351454B1 (ko) * 2005-08-31 2014-01-14 아메데온, 인코포레이티드 위장 및 중추 신경계 장애의 치료에 유용한 입체이성질체 화합물의 합성 방법 및 중간 생성물
US20090042926A1 (en) * 2005-12-20 2009-02-12 Jason Imbriglio Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
KR100750593B1 (ko) * 2006-03-16 2007-08-20 동우신테크 주식회사 치환된 벤즈아미드 유도체의 제조방법
WO2007149929A1 (en) * 2006-06-23 2007-12-27 Aryx Therapeutics, Inc. Piperidine derivatives for the treatment of gastrointestinal and cns disorders
KR20100105802A (ko) 2007-04-19 2010-09-29 콘서트 파마슈티컬즈, 인크. 중수소화된 모르폴리닐 화합물
CN101402633A (zh) * 2007-09-11 2009-04-08 上海恒瑞医药有限公司 苯甲酰胺类衍生物、其制备方法及其在医药上的用途
ES2393640T3 (es) 2008-02-13 2012-12-26 Dainippon Sumitomo Pharma Co., Ltd. Comprimidos bucodisgregables
TWI423967B (zh) * 2008-02-21 2014-01-21 Dainippon Sumitomo Pharma Co 醯胺衍生物及含有其之醫藥組合物
CN102548542B (zh) 2009-08-11 2013-11-20 大日本住友制药株式会社 含有两种以上粒子的口腔速崩片
WO2011107903A1 (en) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Highly pure mosapride citrate dihydrate and processes for its preparation
CN103402997B (zh) 2011-02-25 2015-08-26 柳韩洋行 二氨基嘧啶衍生物及其制备方法
KR101657616B1 (ko) 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CN111349052B (zh) * 2020-04-07 2021-02-12 福建海西新药创制有限公司 一种枸橼酸莫沙必利的合成方法
CN114560822B (zh) * 2020-11-27 2024-05-28 鲁南制药集团股份有限公司 一种莫沙必利的二羧酸晶体
CN114591260B (zh) * 2020-12-05 2025-07-11 鲁南制药集团股份有限公司 一种莫沙必利有机酸盐
CN119241464A (zh) * 2024-10-22 2025-01-03 吉林修正药业新药开发有限公司 一种枸橼酸莫沙必利杂质化合物及其制备方法
CN119241463A (zh) * 2024-10-22 2025-01-03 吉林修正药业新药开发有限公司 一种枸橼酸莫沙必利杂质化合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH451142A (de) * 1965-01-19 1968-05-15 Sandoz Ag Verfahren zur Herstellung neuer basisch substituierter Benzoesäureamide
US4029786A (en) * 1972-08-11 1977-06-14 Imperial Chemical Industries Limited Morpholine derivatives for treating depression
US4323503A (en) * 1976-08-04 1982-04-06 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene di (oxy) benzamides and derivatives
US4210754A (en) * 1977-02-01 1980-07-01 Hoffmann-La Roche Inc. Morpholino containing benzamides
US4692445A (en) * 1983-04-29 1987-09-08 Rorer Pharmaceutical Corporation Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
FR2575158B1 (fr) * 1984-12-20 1987-10-02 Pf Medicament Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
JPH0390274A (ja) * 1989-08-28 1991-04-16 Furukawa Alum Co Ltd Ａｌ又はＡｌ合金の気相ろう付法

Also Published As

Publication number Publication date
DE3781195D1 (de) 1992-09-24
EP0243959B1 (en) 1992-08-19
FI871828A7 (fi) 1987-10-31
NZ220120A (en) 1989-06-28
HK18194A (en) 1994-03-11
FI87776B (fi) 1992-11-13
DE3781195T2 (de) 1993-02-18
US4870074A (en) 1989-09-26
EP0243959A1 (en) 1987-11-04
AU592177B2 (en) 1990-01-04
AR242953A1 (es) 1993-06-30
CZ289787A3 (cs) 1998-11-11
CZ284687B6 (cs) 1999-02-17
PH24049A (en) 1990-03-05
SU1597101A3 (ru) 1990-09-30
CA1291135C (en) 1991-10-22
GR3005934T3 (2) 1993-06-07
KR870010030A (ko) 1987-11-30
FI87776C (fi) 1993-02-25
SK279058B6 (sk) 1998-06-03
HUT45514A (en) 1988-07-28
FI871828A0 (fi) 1987-04-27
DK175281B1 (da) 2004-08-09
AU7227587A (en) 1987-11-05
SK289787A3 (en) 1998-06-03
HU198193B (en) 1989-08-28
DK218787D0 (da) 1987-04-29
DK218787A (da) 1987-10-31

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