ES2043762T3 - Reactivos desnaturalizantes para la determinacion conveniente de derivados de hemoglobina en sangre. - Google Patents

Reactivos desnaturalizantes para la determinacion conveniente de derivados de hemoglobina en sangre.

Info

Publication number
ES2043762T3
ES2043762T3 ES88118104T ES88118104T ES2043762T3 ES 2043762 T3 ES2043762 T3 ES 2043762T3 ES 88118104 T ES88118104 T ES 88118104T ES 88118104 T ES88118104 T ES 88118104T ES 2043762 T3 ES2043762 T3 ES 2043762T3
Authority
ES
Spain
Prior art keywords
hemoglobin
blood
derivative
measured
denaturalizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88118104T
Other languages
English (en)
Inventor
Lowry Messenger
Frances M Yeager
Kin Fai Yip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ES2043762T3 publication Critical patent/ES2043762T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

UN METODO ANCLITICO PARA DETERMINAR LA RELATIVA CANTIDAD DE UN PARTICULAR DERIVADO DE LA EMOGLOBINA, EJEMPLO: EN UNA MUESTRA DE SANGRE DONDE LAS CANTIDADES TOTALES DE HEMOGLOBINA Y DERIVADO DE LA MISMA SON CALCULADOS Y RELACIONADOS MATEMATICAMENTE, EJEM., ASI COMO UN PORCENTAJE, LA MUESTRA DE SANGRE ES TRATADA CON LA CONVICCION DE UNA SAL TIOCENATADA Y UN OXIDENTE PARA DENATURAR LA HEMOGLOBINA EN UNA MUESTRA, Y PARA CONVERTIR HEMOGLOBINA EN LLET-HEMOGLOBINA. ESTA ULTIMA ES CALCULADA ESPECTROMETRICAMENTE PARA DAR LA CANTIDAD DE HEMOGLOBINA TOTAL PRESENTE Y LA HEMOGLOBINA DENATURADA Y DERIVADA PUEDE SER DISTINGUIDA Y CALCULADA POR UN INMUNOENSAYO. LA PRESENCIA DEL OXIDANTE Y LA SOLUCION DENATURANTE HA SIDO ENCONTRADA PARA INCREMENTAR EL TANTO POR CIENTO DE DESNATURALIZACION DE LA HEDMOGLOBINA ASI COMO REDUCIENDO SOBRE TODO EL TIEMPO DE ENSAYO Y AUMENTANDO LA SEGURIDAD DE LA DETERMINACION.
ES88118104T 1987-11-09 1988-10-31 Reactivos desnaturalizantes para la determinacion conveniente de derivados de hemoglobina en sangre. Expired - Lifetime ES2043762T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/118,476 US4970171A (en) 1987-11-09 1987-11-09 Denaturant reagents for convenient determination of hemoglobin derivatives in blood

Publications (1)

Publication Number Publication Date
ES2043762T3 true ES2043762T3 (es) 1994-01-01

Family

ID=22378843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88118104T Expired - Lifetime ES2043762T3 (es) 1987-11-09 1988-10-31 Reactivos desnaturalizantes para la determinacion conveniente de derivados de hemoglobina en sangre.

Country Status (11)

Country Link
US (1) US4970171A (es)
EP (1) EP0315864B1 (es)
JP (1) JP2683572B2 (es)
AT (1) ATE83561T1 (es)
AU (1) AU601086B2 (es)
CA (1) CA1340220C (es)
DE (1) DE3876761T2 (es)
DK (1) DK174495B1 (es)
ES (1) ES2043762T3 (es)
IE (1) IE62086B1 (es)
IL (1) IL87682A (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162237A (en) * 1988-04-11 1992-11-10 Miles Inc. Reaction cassette for preforming sequential analytical assays by noncentrifugal and noncapillary manipulations
IL94724A (en) * 1989-07-13 1994-02-27 Miles Inc Decomposition of red blood cells and denaturation of hemoglobin by the use of lithium salts
US5258311A (en) * 1989-07-13 1993-11-02 Miles Inc. Lithium salts as red blood cell lysing and hemoglobin denaturing reagents
US5151369A (en) * 1989-07-13 1992-09-29 Miles Inc. Lithium salts as red blood cell lysing and hemoglobin denaturing reagents
US5183739A (en) * 1990-02-27 1993-02-02 Exocell, Inc. Monoclonal antibodies specific for non-a1c glycated hemoglobin and immunoassay methods
DE4206932A1 (de) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh Immunologische methode zur bestimmung eines haemoglobinderivates
WO1994000592A1 (en) * 1992-06-26 1994-01-06 Exocell, Inc. Monoclonal antibodies against glycated low density lipoprotein
US5372948A (en) * 1993-03-17 1994-12-13 Miles Inc. Assay and reaction vessel with a compartmentalized solubilization chamber
US6043043A (en) * 1993-04-02 2000-03-28 Bayer Corporation Method for the determination of hemoglobin adducts
US5874229A (en) * 1995-08-07 1999-02-23 Kyoto Daiichi Kagaku Co., Ltd. Method for avoiding influence of hemoglobin
JP3269765B2 (ja) 1995-12-14 2002-04-02 富士写真フイルム株式会社 ヘモグロビン誘導体の免疫学的測定方法及びその方法に用いる処理試薬
US5902731A (en) * 1998-09-28 1999-05-11 Lifescan, Inc. Diagnostics based on tetrazolium compounds
JPWO2002021142A1 (ja) * 2000-09-07 2004-01-15 和光純薬工業株式会社 総ヘモグロビン及び糖化ヘモグロビンの測定方法
DE10054055A1 (de) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Verfahren zur Analyse von Proteinen
WO2002088185A2 (en) * 2001-04-26 2002-11-07 Dakocytomation Denmark A/S Pan-specific monoclonal antibody
US6562581B2 (en) 2001-08-31 2003-05-13 Portascience Method for quantitative determination of glycated hemoglobin
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US20050227370A1 (en) * 2004-03-08 2005-10-13 Ramel Urs A Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
JP4957547B2 (ja) * 2005-04-14 2012-06-20 パナソニック株式会社 ヘモグロビン誘導体の測定方法、それに用いる試薬組成物、測定キット、分析デバイス、及び分析システム
WO2007077579A1 (en) * 2006-01-04 2007-07-12 Jawaharlal Nehru University A novelprocess for detecting human haemoglobin variants
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
JP4437216B2 (ja) * 2007-01-30 2010-03-24 アークレイ株式会社 フェノチアジン誘導体色素の検出方法およびそれに用いる発色剤試薬
EP2210113B1 (en) * 2007-11-20 2015-05-27 Siemens Healthcare Diagnostics Inc. Methods for the detection of glycated hemoglobin
WO2010067612A1 (ja) 2008-12-11 2010-06-17 積水メディカル株式会社 糖化ヘモグロビン含有試料の前処理法
ES2961300T3 (es) 2010-03-31 2024-03-11 Sekisui Medical Co Ltd Método para analizar hemoglobinas
WO2016054033A1 (en) * 2014-09-30 2016-04-07 Siemens Healthcare Diagnostics Inc. Processes, systems, and devices for hemolysis detection via measurement of methemoglobin
EP3528950A4 (en) 2016-10-24 2020-05-27 Biomatrica, INC. STABILIZATION OF NUCLEIC ACIDS ON PAPER
WO2019203302A1 (ja) * 2018-04-18 2019-10-24 積水メディカル株式会社 ヘモグロビン分析方法
CN112113955B (zh) * 2020-09-15 2022-03-18 四川行之智汇知识产权运营有限公司 血红蛋白检测卡
CN113866406B (zh) * 2021-10-18 2022-09-27 深圳上泰生物工程有限公司 一种特异性检测糖缺失性转铁蛋白的试剂盒

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247533A (en) * 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
US4255385A (en) * 1979-10-23 1981-03-10 Abbott Laboratories Reagent and test kit for determining glycosylated hemoglobin
US4260516A (en) * 1979-12-07 1981-04-07 Abbott Laboratories Glycosylated hemoglobin standards
US4649122A (en) * 1980-09-02 1987-03-10 Leeco Diagnostics, Inc. Means for determining percentage of glycohemoglobin in whole blood
US4407961A (en) * 1981-03-16 1983-10-04 Sanders James L Ion-exchange system and method for isolation and determination of glycosylated hemoglobin in human blood
DE3141146A1 (de) * 1981-10-16 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung von glykosiliertem haemoglobin
US4880749A (en) * 1984-06-05 1989-11-14 Eastman Kodak Company Analytical element and its use in a whole blood hemoglobin assay
CA1339952C (en) * 1984-10-29 1998-07-14 William J. Knowles Immunoassays for denatured protein analytes, particularly hb alc, and monoclonal antibodies thereto
US4647654A (en) * 1984-10-29 1987-03-03 Molecular Diagnostics, Inc. Peptides useful in preparing hemoglobin A1c immunogens
US4658022A (en) * 1985-08-08 1987-04-14 Molecular Diagnostics, Inc. Binding of antibody reagents to denatured protein analytes
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse
US4800167A (en) * 1987-04-10 1989-01-24 Abbott Laboratories Reagent and process for the determination of hemoglobin in blood

Also Published As

Publication number Publication date
IL87682A0 (en) 1989-02-28
DK622788A (da) 1989-05-10
US4970171A (en) 1990-11-13
JP2683572B2 (ja) 1997-12-03
AU2465588A (en) 1989-05-11
JPH01155268A (ja) 1989-06-19
DK622788D0 (da) 1988-11-08
DK174495B1 (da) 2003-04-22
DE3876761D1 (de) 1993-01-28
EP0315864A1 (en) 1989-05-17
AU601086B2 (en) 1990-08-30
EP0315864B1 (en) 1992-12-16
DE3876761T2 (de) 1993-04-22
IE62086B1 (en) 1994-12-14
IE883356L (en) 1989-05-09
IL87682A (en) 1992-08-18
CA1340220C (en) 1998-12-15
ATE83561T1 (de) 1993-01-15

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