ES2046107A1 - Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina. - Google Patents
Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina.Info
- Publication number
- ES2046107A1 ES2046107A1 ES9200500A ES9200500A ES2046107A1 ES 2046107 A1 ES2046107 A1 ES 2046107A1 ES 9200500 A ES9200500 A ES 9200500A ES 9200500 A ES9200500 A ES 9200500A ES 2046107 A1 ES2046107 A1 ES 2046107A1
- Authority
- ES
- Spain
- Prior art keywords
- hetero
- methyl piperazine
- cycloalkenyl
- cycloalkyl
- phenyl methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001072 heteroaryl group Chemical group 0.000 title abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 title abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- -1 cycloalkenyl acid chloride Chemical compound 0.000 title 1
- NWVNXDKZIQLBNM-UHFFFAOYSA-N diphenylmethylpiperazine Chemical compound C1CNCCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 NWVNXDKZIQLBNM-UHFFFAOYSA-N 0.000 abstract 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005237 alkyleneamino group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003326 anti-histaminergic effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000008640 diphenylmethylpiperazines Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE DESCRIBE LA PREPARACION DE NUEVOS DERIVADOS DE LA DIFENILMETILPIPERACINA DE FORMULA: FORMULA EN DONDE A ES UN GRUPO CARBONILO O ALQUILAMINOCARBONILO Y B ES UN GRUPO HETEROARILO, SUSTITUIDO O NO, CICLOALQUILO O CICLOALQUENILO, ASI COMO SUS SALES DE ADICION FARMACEUTICAMENTE ESTABLES. LOS NUEVOS DERIVADOS SE SINTETIZAN HACIENDO REACCIONAR LA DIFENILMETILPIPERACINA, O UN DERIVADO ALQUILENAMINO DE LA MISMA, CON UN CLORURO DE UN ACIDO HETEROAROMATICO, EN EL QUE EL HETEROATOMO ES PREFERENTEMENTE UN NITROGENO Y QUE ESTA SUSTITUIDO POR UN HALOGENO, PREFERENTEMENTE CLORO O BROMO; O CON EL CLORURO DE UN ACIDO BICICLOALCANOICO O ALQUENOICO. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD FARMACOLOGICA, EN PARTICULAR ANTIHISTAMINICA Y ANTIALERGICA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9200500A ES2046107B1 (es) | 1992-03-05 | 1992-03-05 | Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9200500A ES2046107B1 (es) | 1992-03-05 | 1992-03-05 | Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2046107A1 true ES2046107A1 (es) | 1994-01-16 |
| ES2046107B1 ES2046107B1 (es) | 1994-08-01 |
Family
ID=8276315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9200500A Expired - Fee Related ES2046107B1 (es) | 1992-03-05 | 1992-03-05 | Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2046107B1 (es) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3267104A (en) * | 1964-06-09 | 1966-08-16 | Janssen Pharmaceutica Nv | 1, 4-disubstituted piperazines and diazepines |
| ES8203870A1 (es) * | 1980-06-16 | 1982-04-01 | Ferrosan Ab | Procedimiento para preparar difenilbutil-1-acilpiperazinas |
| EP0210782A2 (en) * | 1985-07-19 | 1987-02-04 | Dainippon Pharmaceutical Co., Ltd. | Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same |
| EP0343961A2 (en) * | 1988-05-24 | 1989-11-29 | American Home Products Corporation | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity |
-
1992
- 1992-03-05 ES ES9200500A patent/ES2046107B1/es not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3267104A (en) * | 1964-06-09 | 1966-08-16 | Janssen Pharmaceutica Nv | 1, 4-disubstituted piperazines and diazepines |
| ES8203870A1 (es) * | 1980-06-16 | 1982-04-01 | Ferrosan Ab | Procedimiento para preparar difenilbutil-1-acilpiperazinas |
| EP0210782A2 (en) * | 1985-07-19 | 1987-02-04 | Dainippon Pharmaceutical Co., Ltd. | Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same |
| EP0343961A2 (en) * | 1988-05-24 | 1989-11-29 | American Home Products Corporation | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2046107B1 (es) | 1994-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991102 |