ES2046237T3 - Acidos boronicos peptidos inhibidores de proteasas de tipo tripsinico. - Google Patents

Acidos boronicos peptidos inhibidores de proteasas de tipo tripsinico.

Info

Publication number
ES2046237T3
ES2046237T3 ES198888108817T ES88108817T ES2046237T3 ES 2046237 T3 ES2046237 T3 ES 2046237T3 ES 198888108817 T ES198888108817 T ES 198888108817T ES 88108817 T ES88108817 T ES 88108817T ES 2046237 T3 ES2046237 T3 ES 2046237T3
Authority
ES
Spain
Prior art keywords
peptides
tripsinic
boronic
protease inhibiting
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888108817T
Other languages
English (en)
Inventor
Charles Adrian Kettner
Ashokkumar Bhikkappa Shenvi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of ES2046237T3 publication Critical patent/ES2046237T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LOS PEPTIDOS QUE CONTIENEN ACIDO BORONICO C-TERMINAL DERIVADOS DE LISINA, ORNITINA Y ARGININA, HOMOARGININA Y SUS CORRESPONDIENTES ANALOGOS DE ISOTIOURONIO, SON INHIBIDORES REVERSIBLES DE PROTEASAS SERINAS DE TIPO TRIPSINA TAL COMO TROMBINA, CALICREINA DEL PLASMA Y PLASMINA.
ES198888108817T 1987-06-05 1988-06-01 Acidos boronicos peptidos inhibidores de proteasas de tipo tripsinico. Expired - Lifetime ES2046237T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5967087A 1987-06-05 1987-06-05
US07/178,368 US5187157A (en) 1987-06-05 1988-04-06 Peptide boronic acid inhibitors of trypsin-like proteases

Publications (1)

Publication Number Publication Date
ES2046237T3 true ES2046237T3 (es) 1994-02-01

Family

ID=26739035

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888108817T Expired - Lifetime ES2046237T3 (es) 1987-06-05 1988-06-01 Acidos boronicos peptidos inhibidores de proteasas de tipo tripsinico.

Country Status (16)

Country Link
US (1) US5187157A (es)
EP (1) EP0293881B1 (es)
JP (1) JPH0730090B2 (es)
KR (1) KR910003619B1 (es)
AU (1) AU623592B2 (es)
CA (1) CA1328332C (es)
DE (1) DE3878991T2 (es)
DK (1) DK304488A (es)
ES (1) ES2046237T3 (es)
FI (1) FI97297C (es)
HU (1) HU205141B (es)
IE (1) IE64787B1 (es)
IL (1) IL86613A (es)
NO (1) NO882472L (es)
NZ (1) NZ224903A (es)
PT (1) PT87652B (es)

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* Cited by examiner, † Cited by third party
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KR910003619B1 (ko) 1991-06-07
IE881666L (en) 1988-12-05
AU623592B2 (en) 1992-05-21
EP0293881A3 (en) 1990-05-30
PT87652A (pt) 1988-07-01
HU205141B (en) 1992-03-30
DE3878991T2 (de) 1993-07-15
EP0293881B1 (en) 1993-03-10
FI97297C (fi) 1996-11-25
NO882472L (no) 1988-12-06
IE64787B1 (en) 1995-09-06
FI882638L (fi) 1988-12-06
NZ224903A (en) 1990-02-26
IL86613A (en) 1993-04-04
IL86613A0 (en) 1988-11-30
PT87652B (pt) 1992-09-30
FI882638A0 (fi) 1988-06-03
DE3878991D1 (de) 1993-04-15
DK304488A (da) 1988-12-06
JPH0730090B2 (ja) 1995-04-05
HUT49629A (en) 1989-10-30
KR890000514A (ko) 1989-03-15
EP0293881A2 (en) 1988-12-07
US5187157A (en) 1993-02-16
DK304488D0 (da) 1988-06-03
CA1328332C (en) 1994-04-05
NO882472D0 (no) 1988-06-03
AU1733288A (en) 1988-12-08
FI97297B (fi) 1996-08-15
JPS6463583A (en) 1989-03-09

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