ES2047457B1 - PROCEDURE TO OBTAIN ACICLOVIR. - Google Patents
PROCEDURE TO OBTAIN ACICLOVIR.Info
- Publication number
- ES2047457B1 ES2047457B1 ES9201629A ES9201629A ES2047457B1 ES 2047457 B1 ES2047457 B1 ES 2047457B1 ES 9201629 A ES9201629 A ES 9201629A ES 9201629 A ES9201629 A ES 9201629A ES 2047457 B1 ES2047457 B1 ES 2047457B1
- Authority
- ES
- Spain
- Prior art keywords
- aciclovir
- formula
- procedure
- reaction
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004150 aciclovir Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VRSMQRZDMZDXAU-UHFFFAOYSA-N bis(sulfanylidene)niobium Chemical compound S=[Nb]=S VRSMQRZDMZDXAU-UHFFFAOYSA-N 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER ACICLOVIR, DE FORMULA I, Y DE SUS HIDRATOS, QUE COMPRENDE LA REACCION DE LA TRIS-(NBS2 SC,0,9TRIMETILSILIL)GUANINA, CON EL DIACETATO DE 2-OXA-1,4-BUTANODIOL, DANDO LUGAR, TRAS LA HIDROLISIS DEL CRUDO DE REACCION, A UN COMPUESTO DE FORMULA IV, FORMULA EL CUAL SE HACE REACCIONAR CON UNA BASE EN EL SENO DE UN DISOLVENTE PARA OBTENER EL COMPUESTO DE FORMULA I. EL ACICLOVIR ES UN AGENTE ANTIVIRICO DE BAJA CITOTOXICIDAD, UTILIZADO EN TERAPEUTICA PARA EL TRATAMIENTO DE INFECCIONES CAUSADAS POR EL VIRUS DEL HERPES.PROCEDURE FOR OBTAINING ACICLOVIR, FROM FORMULA I, AND ITS HYDRATES, WHICH INCLUDES THE REACTION OF TRIS- (NBS2 SC, 0,9 TRIMETILSILIL) GUANINA, WITH THE DIACETATE OF 2-OXA-1,4-BUTANODIOL, GIVING PLACE, AFTER THE HYDROLYSIS OF THE CRUDE OF REACTION, TO A COMPOUND OF FORMULA IV, FORMULATES WHICH IS REACTIONED WITH A BASIS IN THE BREAST OF A SOLVENT TO OBTAIN THE COMPOUND OF FORMULA I. ACICLOVIR IS A LOW CYTOTOXICITY ANTIVIRIC AGENT FOR THE TREATMENT OF INFECTIONS CAUSED BY THE HERPES VIRUS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9201629A ES2047457B1 (en) | 1992-08-03 | 1992-08-03 | PROCEDURE TO OBTAIN ACICLOVIR. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9201629A ES2047457B1 (en) | 1992-08-03 | 1992-08-03 | PROCEDURE TO OBTAIN ACICLOVIR. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2047457A1 ES2047457A1 (en) | 1994-02-16 |
| ES2047457B1 true ES2047457B1 (en) | 1994-10-01 |
Family
ID=8277878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9201629A Expired - Lifetime ES2047457B1 (en) | 1992-08-03 | 1992-08-03 | PROCEDURE TO OBTAIN ACICLOVIR. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2047457B1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6811595B2 (en) | 2002-09-04 | 2004-11-02 | Xerox Corporation | Guanidinopyrimidinone compounds and phase change inks containing same |
| US6860928B2 (en) | 2002-09-04 | 2005-03-01 | Xerox Corporation | Alkylated urea and triaminotriazine compounds and phase change inks containing same |
| CN101602764B (en) * | 2009-03-27 | 2011-06-29 | 浙江车头制药有限公司 | Method for preparing acyclovir 2/3 hydrate |
| CN121085919B (en) * | 2025-09-11 | 2026-04-28 | 浙江浙北药业有限公司 | A method for synthesizing high-purity acyclovir and its application |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
| ES520140A0 (en) * | 1983-02-25 | 1984-04-01 | Ind Farma Especial | A PROCEDURE FOR THE PREPARATION OF ACICLOGUANOSIN. |
| ES528049A0 (en) * | 1983-10-27 | 1985-06-16 | Pharmainvesti S A | PROCEDURE FOR THE ELABORATION OF DERIVATIVES OF 9 2 HYDROXY-ETOXI-METHYL PURINE |
| YU45690B (en) * | 1984-12-22 | 1992-07-20 | Krka Tovarna Zdraviln.Sol.O. | PROCEDURE FOR PREPARING 9- (2-HYDROXYETHOXYMETHYL) -GUANINE |
-
1992
- 1992-08-03 ES ES9201629A patent/ES2047457B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2047457A1 (en) | 1994-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA2A | Application withdrawn |
Effective date: 19950425 |