ES2047757T3 - Hidrogeno carbonato que contiene concentrado acuoso y un sistema de bolsas de dos camaras para la preparacion de un liquido de dialisis destinado a la capd. - Google Patents
Hidrogeno carbonato que contiene concentrado acuoso y un sistema de bolsas de dos camaras para la preparacion de un liquido de dialisis destinado a la capd.Info
- Publication number
- ES2047757T3 ES2047757T3 ES90109963T ES90109963T ES2047757T3 ES 2047757 T3 ES2047757 T3 ES 2047757T3 ES 90109963 T ES90109963 T ES 90109963T ES 90109963 T ES90109963 T ES 90109963T ES 2047757 T3 ES2047757 T3 ES 2047757T3
- Authority
- ES
- Spain
- Prior art keywords
- capd
- preparation
- hydrogen carbonate
- containing aqueous
- bag system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 title abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 2
- 238000000502 dialysis Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000012141 concentrate Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE DESCRIBE UNA NUEVA SOLUCION DE BICARBONATO PARA LA OBTENCION DE LIQUIDOS DIALIZADOS O DE DIALISIS PARA LIMPIAR LA SANGRE, PARTICULARMENTE CAPD, Y CUYO VALOR DE PH SE REBAJA, MEDIANTE LA ADICION DE UN ACIDO FISIOLOGICAMENTE COMPATIBLE, POR DEBAJO DE 7,6. CON UNA MEZCLA DE ESTA SOLUCION DE BICARBONATO CON UNA SOLUCION ACIDA QUE CONTENGA IONES DE CALCIO NO SE PRECIPITA NINGUN CARBONATO DE CALCIO AUN CUANDO SEA MAS ALTA LA CONCENTRACION DE BICARBONATO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3917251A DE3917251A1 (de) | 1989-05-26 | 1989-05-26 | Natriumbicarbonat enthaltendes konzentrat sowie verfahren zur herstellung einer dialysierfluessigkeit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2047757T3 true ES2047757T3 (es) | 1994-03-01 |
| ES2047757T5 ES2047757T5 (es) | 1999-09-16 |
Family
ID=6381493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90109963T Expired - Lifetime ES2047757T5 (es) | 1989-05-26 | 1990-05-25 | Sistema de bolsas de dos camaras para la preparacion de un liquido de dialisis destinado a la capd. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5211643A (es) |
| EP (1) | EP0399549B2 (es) |
| JP (1) | JP2781447B2 (es) |
| KR (1) | KR0163425B1 (es) |
| AU (1) | AU633917B2 (es) |
| BR (1) | BR9002474A (es) |
| CA (1) | CA2017531C (es) |
| DE (2) | DE3917251A1 (es) |
| ES (1) | ES2047757T5 (es) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5032615A (en) * | 1989-10-31 | 1991-07-16 | The Regents Of The University Of California | Continuous hemodialysis using citrate |
| EP0457960A3 (en) * | 1990-05-17 | 1993-01-07 | Minntech Corporation | High acid concentration dialysates |
| DE4039471A1 (de) * | 1990-12-11 | 1992-06-25 | Braun Melsungen Ag | Spezialkonzentrat fuer die bicarbonat-dialyse und seine verwendung |
| DE4122754A1 (de) * | 1991-07-10 | 1993-01-21 | Martin Prof Dr Med Vlaho | Herstellung einer substitutionsloesung fuer die haemofiltration bei dialyseverfahren |
| SE9103395D0 (sv) * | 1991-11-18 | 1991-11-18 | Gambro Ab | System med anvaendning av ensteril medicinsk loesning innehaallande glukos eller glukosliknande aemnen samt en loesning avsedd foer detta system |
| US5827820A (en) * | 1992-04-06 | 1998-10-27 | Baxter International Inc. | Aqueous peritoneal dialysis solution |
| DE4211455C1 (de) * | 1992-04-06 | 1993-12-16 | Schael Wilfried | Verfahren und Vorrichtung zur Bereitung von Dialysierflüssigkeit für die Hämodialyse |
| ATE139451T1 (de) * | 1992-04-06 | 1996-07-15 | Baxter Int | Wässrige peritonealdialyse-lösung |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| ATE196602T1 (de) * | 1993-02-19 | 2000-10-15 | Schael Wilfried | Verfahren zur bereitung von bicarbonathaltigen dialysierflüssigkeiten für die hämodialyse |
| US5383324A (en) * | 1993-04-23 | 1995-01-24 | Baxter International Inc. | Method for manufacturing and storing stable bicarbonate solutions |
| IL107088A (en) * | 1993-09-23 | 1997-01-10 | Travenol Lab Israel Ltd | Multi-compartment bag |
| US5589197A (en) * | 1993-10-04 | 1996-12-31 | Baxter International, Inc. | Low sodium peritoneal dialysis solution |
| AU701724B2 (en) * | 1994-07-01 | 1999-02-04 | Baxter International Inc. | Biochemically balanced peritoneal dialysis solutions |
| US5605934A (en) * | 1995-03-23 | 1997-02-25 | Baxter International Inc. | Method of manufacturing and storing solutions |
| US5674190A (en) * | 1995-08-28 | 1997-10-07 | Organetics, Ltd. | Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2 |
| US5925011A (en) † | 1995-08-30 | 1999-07-20 | Baxter International Inc. | System and method for providing sterile fluids for admixed solutions in automated peritoneal dialysis |
| US6436969B1 (en) * | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| DE19631124A1 (de) * | 1996-08-01 | 1998-02-05 | Fresenius Medical Care De Gmbh | Verfahren zur Herstellung einer Bicarbonat enthaltenden Infusions- oder Dialysierlösung |
| US5876396A (en) * | 1996-09-27 | 1999-03-02 | Baxter International Inc. | System method and container for holding and delivering a solution |
| US5945449A (en) * | 1996-11-01 | 1999-08-31 | Dialysis Solutions Inc. | Sterile bicarbonate concentrate |
| DE19748290B8 (de) * | 1997-10-31 | 2009-09-03 | Fresenius Medical Care Deutschland Gmbh | Lösung für die Peritonealdialyse |
| DE19850830B4 (de) | 1998-11-04 | 2004-12-30 | Fresenius Medical Care Deutschland Gmbh | Verfahren zur Herstellung einer Lösung, insbesondere einer Dialyse- oder Infusionslösung |
| WO2000051987A2 (en) | 1999-03-05 | 2000-09-08 | Kansas University Medical Center | Inhibitors of advanced, post-amadori glycosylation reactions |
| US6743191B1 (en) | 1999-04-26 | 2004-06-01 | Edwards Lifesciences Ag | Substitution infusion fluid and citrate anticoagulation |
| US8105258B2 (en) * | 1999-04-26 | 2012-01-31 | Baxter International Inc. | Citrate anticoagulation system for extracorporeal blood treatments |
| US7186420B2 (en) * | 1999-04-26 | 2007-03-06 | Edwards Lifesciences Corporation | Multi-part substitution infusion fluids and matching anticoagulants |
| US6309673B1 (en) | 1999-09-10 | 2001-10-30 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
| US20040215129A1 (en) * | 1999-09-16 | 2004-10-28 | Gambro Ab | Method and cycler for the administration of a peritoneal dialysis fluid |
| US7678097B1 (en) | 1999-11-12 | 2010-03-16 | Baxter International Inc. | Containers and methods for manufacturing same |
| DE19955578C1 (de) * | 1999-11-18 | 2001-09-06 | Fresenius Medical Care De Gmbh | Mehrkammerbehälter, mit Glucosekonzentratkompartiment und Salzsäurekonzentratkompartiment |
| NL1016235C2 (nl) | 2000-09-21 | 2002-03-22 | Adrianus Antonius Marcus Johan | Vloeistof voor hemofiltratie. |
| CA2365787C (en) | 2000-12-20 | 2006-02-14 | Dialysis Solutions Inc. | Sterile low bicarbonate dialysis concentrate solutions |
| EP1343489A2 (en) | 2000-12-20 | 2003-09-17 | Dialysis Solutions Inc. | Sterile bicarbonate-free dialysis concentrate solutions |
| JP2003054621A (ja) * | 2001-08-06 | 2003-02-26 | Hosokawa Yoko Co Ltd | 包材及び包装容器 |
| JP2003088582A (ja) * | 2001-09-19 | 2003-03-25 | Jms Co Ltd | 腹膜透析液および保存容器 |
| AU2008201009B2 (en) * | 2002-01-11 | 2010-07-01 | Nikkiso Co., Ltd. | Bicarbonate-based solutions for dialysis therapies |
| US7122210B2 (en) * | 2002-01-11 | 2006-10-17 | Baxter International Inc. | Bicarbonate-based solutions for dialysis therapies |
| ITMI20020516A1 (it) * | 2002-03-12 | 2003-09-12 | Gambro Lundia Ab | Liquidi per dialisi peritoneale emodialisi e reintegrazione |
| US7445801B2 (en) * | 2002-06-07 | 2008-11-04 | Baxter International Inc. | Stable bicarbonate-based solution in a single container |
| SE526013C2 (sv) * | 2002-11-08 | 2005-06-14 | Gambro Lundia Ab | Behållare med syrabarriär och användning därav |
| US20040121982A1 (en) * | 2002-12-20 | 2004-06-24 | Leo Martis | Biocompatible dialysis fluids containing icodextrins |
| SE0400523D0 (sv) * | 2004-03-01 | 2004-03-01 | Gambro Lundia Ab | A medical solution, a method for producing said medical solution and use thereof |
| SE0400522D0 (sv) * | 2004-03-01 | 2004-03-01 | Gambro Lundia Ab | A medical solution, a method for producing said medical solution and use thereof |
| US20050276868A1 (en) * | 2004-06-10 | 2005-12-15 | Bart Degreve | Bicarbonate-based peritoneal dialysis solutions |
| JP4458346B2 (ja) * | 2004-07-12 | 2010-04-28 | 旭化成クラレメディカル株式会社 | 持続緩徐式血液ろ過透析装置 |
| SE0402507D0 (sv) | 2004-10-14 | 2004-10-14 | Gambro Lundia Ab | Medicinsk lösning, förfarande för framställning och användning därav |
| US7935070B2 (en) * | 2005-01-28 | 2011-05-03 | Fresenius Medical Care North America | Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product |
| US8535522B2 (en) * | 2009-02-12 | 2013-09-17 | Fresenius Medical Care Holdings, Inc. | System and method for detection of disconnection in an extracorporeal blood circuit |
| US8475399B2 (en) * | 2009-02-26 | 2013-07-02 | Fresenius Medical Care Holdings, Inc. | Methods and systems for measuring and verifying additives for use in a dialysis machine |
| US8597505B2 (en) | 2007-09-13 | 2013-12-03 | Fresenius Medical Care Holdings, Inc. | Portable dialysis machine |
| US9308307B2 (en) | 2007-09-13 | 2016-04-12 | Fresenius Medical Care Holdings, Inc. | Manifold diaphragms |
| US8137553B2 (en) | 2007-11-29 | 2012-03-20 | Fresenius Medical Care Holdings, Inc. | Priming system and method for dialysis systems |
| US20090114037A1 (en) * | 2007-10-11 | 2009-05-07 | Mark Forrest Smith | Photo-Acoustic Flow Meter |
| US8240636B2 (en) | 2009-01-12 | 2012-08-14 | Fresenius Medical Care Holdings, Inc. | Valve system |
| US8105487B2 (en) | 2007-09-25 | 2012-01-31 | Fresenius Medical Care Holdings, Inc. | Manifolds for use in conducting dialysis |
| US20090076434A1 (en) * | 2007-09-13 | 2009-03-19 | Mischelevich David J | Method and System for Achieving Volumetric Accuracy in Hemodialysis Systems |
| US9358331B2 (en) | 2007-09-13 | 2016-06-07 | Fresenius Medical Care Holdings, Inc. | Portable dialysis machine with improved reservoir heating system |
| US20090101577A1 (en) * | 2007-09-28 | 2009-04-23 | Fulkerson Barry N | Methods and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements |
| CA2706919C (en) | 2007-11-29 | 2018-03-06 | Fresenius Medical Care Holdings, Inc. | System and method for conducting hemodialysis and hemofiltration |
| US20090214807A1 (en) | 2008-02-27 | 2009-08-27 | Shawn Davis | Peelable seals including porous inserts |
| US20110005958A1 (en) * | 2009-07-09 | 2011-01-13 | Onpharma, Inc. | METHODS AND SYSTEMS FOR ADJUSTING THE pH OF MEDICAL BUFFERING SOLUTIONS |
| US8162917B2 (en) * | 2008-05-21 | 2012-04-24 | Onpharma, Inc. | Methods and apparatus for buffering anesthetics |
| US20100184198A1 (en) * | 2009-01-16 | 2010-07-22 | Joseph Russell T | Systems and Methods of Urea Processing to Reduce Sorbent Load |
| WO2010042667A2 (en) * | 2008-10-07 | 2010-04-15 | Xcorporeal, Inc. | Thermal flow meter |
| JP5628186B2 (ja) | 2008-10-30 | 2014-11-19 | フレセニウス メディカル ケア ホールディングス インコーポレーテッド | モジュール式携帯透析システム |
| WO2010055963A1 (en) * | 2008-11-17 | 2010-05-20 | Lee, Jin Tae | Manufacturing method of acetate-free dialysate composition |
| WO2010114932A1 (en) | 2009-03-31 | 2010-10-07 | Xcorporeal, Inc. | Modular reservoir assembly for a hemodialysis and hemofiltration system |
| PL2454012T3 (pl) * | 2009-07-09 | 2018-04-30 | Onpharma, Inc. | Sposób i urządzenie do sterylizacji i przechowywania wkładów z roztworem buforującym |
| US8585963B2 (en) * | 2009-07-09 | 2013-11-19 | Onpharma, Inc. | Methods and devices for sterilizing and holding buffering solution cartridges |
| US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
| US9201036B2 (en) | 2012-12-21 | 2015-12-01 | Fresenius Medical Care Holdings, Inc. | Method and system of monitoring electrolyte levels and composition using capacitance or induction |
| US9157786B2 (en) | 2012-12-24 | 2015-10-13 | Fresenius Medical Care Holdings, Inc. | Load suspension and weighing system for a dialysis machine reservoir |
| US9433720B2 (en) | 2013-03-14 | 2016-09-06 | Fresenius Medical Care Holdings, Inc. | Universal portable artificial kidney for hemodialysis and peritoneal dialysis |
| US20140263062A1 (en) | 2013-03-14 | 2014-09-18 | Fresenius Medical Care Holdings, Inc. | Universal portable machine for online hemodiafiltration using regenerated dialysate |
| US9354640B2 (en) * | 2013-11-11 | 2016-05-31 | Fresenius Medical Care Holdings, Inc. | Smart actuator for valve |
| DE102018103866A1 (de) * | 2018-02-21 | 2019-08-22 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung enthaltend eine Dialyseslösung |
| CN108992460A (zh) * | 2018-08-31 | 2018-12-14 | 山东威高药业股份有限公司 | 一种血液透析浓缩b液的制备工艺 |
| US11925703B1 (en) | 2022-07-29 | 2024-03-12 | Xellia Pharmaceuticals Aps | Liquid composition comprising glucose |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1017249A (en) * | 1973-12-19 | 1977-09-13 | Chemo Drug Company | Injectable electrolyte solutions |
| US4399036A (en) * | 1979-06-14 | 1983-08-16 | Diachem, Inc. | Proportioning system for bicarbonate dialysate |
| DE2929871A1 (de) * | 1979-07-24 | 1981-01-29 | Gambro Dialysatoren | Waessriges konzentrat fuer dialyse-loesungen |
| DE3146425A1 (de) * | 1980-05-09 | 1982-06-03 | A Babb | System for bicarbonate dialysate |
| US4489535A (en) * | 1980-10-02 | 1984-12-25 | Veltman Preston Leonard | Materials and method for preparing dialysis solutions containing bicarbonate ions |
| DE3224823A1 (de) * | 1982-07-02 | 1984-01-05 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer fuer den entsprechenden krankheitsfall optimierten elektrolytloesung zur anwendung in der haemodialyse |
| US4507114A (en) * | 1983-10-21 | 1985-03-26 | Baxter Travenol Laboratories, Inc. | Multiple chamber container having leak detection compartment |
| US4591049A (en) * | 1984-01-16 | 1986-05-27 | Kidde, Inc. | Hermetically sealed two-component mixing system |
| IT1214872B (it) * | 1984-04-06 | 1990-01-18 | Mariano Feriani | Sacca contenente due o piu'sostanze per infusione ad uso medicale, poste in scomparti separati, comprendente mezzi atti a consentire la miscelazione di tali sostanze solo al momento dell'uso. |
| US4608043A (en) * | 1984-06-22 | 1986-08-26 | Abbott Laboratories | I.V. fluid storage and mixing system |
| US4663166A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vivo use thereof |
| GR870129B (en) * | 1987-01-27 | 1987-02-04 | Giatzidis Ippokratis | Stable bicarbonate - glycylglycine dialysate for hemodialysis and peritoneal dialysis |
-
1989
- 1989-05-26 DE DE3917251A patent/DE3917251A1/de active Granted
-
1990
- 1990-05-23 AU AU55813/90A patent/AU633917B2/en not_active Expired
- 1990-05-25 KR KR1019900007601A patent/KR0163425B1/ko not_active Expired - Fee Related
- 1990-05-25 DE DE90109963T patent/DE59003505D1/de not_active Expired - Lifetime
- 1990-05-25 ES ES90109963T patent/ES2047757T5/es not_active Expired - Lifetime
- 1990-05-25 US US07/528,855 patent/US5211643A/en not_active Expired - Lifetime
- 1990-05-25 BR BR909002474A patent/BR9002474A/pt not_active Application Discontinuation
- 1990-05-25 JP JP2136933A patent/JP2781447B2/ja not_active Expired - Lifetime
- 1990-05-25 CA CA002017531A patent/CA2017531C/en not_active Expired - Lifetime
- 1990-05-25 EP EP90109963A patent/EP0399549B2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR0163425B1 (ko) | 1998-11-16 |
| BR9002474A (pt) | 1991-08-13 |
| AU633917B2 (en) | 1993-02-11 |
| CA2017531C (en) | 1999-07-27 |
| EP0399549A1 (de) | 1990-11-28 |
| JP2781447B2 (ja) | 1998-07-30 |
| JPH03103265A (ja) | 1991-04-30 |
| CA2017531A1 (en) | 1990-11-26 |
| ES2047757T5 (es) | 1999-09-16 |
| EP0399549B2 (de) | 1999-05-26 |
| EP0399549B1 (de) | 1993-11-18 |
| DE3917251C2 (es) | 1993-03-11 |
| KR900017615A (ko) | 1990-12-19 |
| US5211643A (en) | 1993-05-18 |
| AU5581390A (en) | 1990-11-29 |
| DE59003505D1 (de) | 1993-12-23 |
| DE3917251A1 (de) | 1990-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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