ES2048110A1 - Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos. - Google Patents

Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos.

Info

Publication number
ES2048110A1
ES2048110A1 ES9201532A ES9201532A ES2048110A1 ES 2048110 A1 ES2048110 A1 ES 2048110A1 ES 9201532 A ES9201532 A ES 9201532A ES 9201532 A ES9201532 A ES 9201532A ES 2048110 A1 ES2048110 A1 ES 2048110A1
Authority
ES
Spain
Prior art keywords
thiadiazine
dioxides
straight
pharmaceuticals
branched chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9201532A
Other languages
English (en)
Other versions
ES2048110B1 (es
Inventor
Loza Goya
Proper Paes
Yufera Carrasco
Mateo Grau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Prodesfarma SA
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Prodesfarma SA filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES09201532A priority Critical patent/ES2048110B1/es
Priority to AT92500133T priority patent/ATE149499T1/de
Priority to DE69217926T priority patent/DE69217926T2/de
Priority to ES92500133T priority patent/ES2099810T3/es
Priority to DK92500133.1T priority patent/DK0580916T3/da
Priority to EP92500133A priority patent/EP0580916B1/en
Priority to ZA934926A priority patent/ZA934926B/xx
Priority to NO932525A priority patent/NO303874B1/no
Priority to AU41898/93A priority patent/AU670289B2/en
Priority to CA002100429A priority patent/CA2100429A1/en
Priority to US08/093,256 priority patent/US5580869A/en
Priority to NZ248196A priority patent/NZ248196A/en
Priority to FI933267A priority patent/FI933267A7/fi
Priority to KR1019930013761A priority patent/KR100226342B1/ko
Priority to MX9304430A priority patent/MX9304430A/es
Priority to JP5181435A priority patent/JPH06184163A/ja
Publication of ES2048110A1 publication Critical patent/ES2048110A1/es
Application granted granted Critical
Publication of ES2048110B1 publication Critical patent/ES2048110B1/es
Priority to GR970401297T priority patent/GR3023653T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Liquid Crystal Substances (AREA)
  • Coloring (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE 2,2-DIOXIDOS DE PIRAZINO[2,3-C]-1,2,6-TIADIAZINA N(1) SUSTITUIDOS, DE FORMULA I (RSI1 SC Y RSI2 SC SON HIDROGENO, ALQUILO, ARILO, TRIFLUOROMETILO, HALOGENO, OXO, AMINO, CARBOXAMIDO, ALCOXICARBONILO O SUS SALES FARMACEUTICAMENTE ACEPTABLES DE CATIONES ORGANICOS O INORGANICOS; RSI3 SC ES ALQUILO, DIALQUILAMINOETILO, ARALQUILO, ALCOXICARBONILMETILO, CARBOXIMETILO O HIDROXIETILO; Y RSI4 SC Y RSI5 SC SON HIDROGENO, ALQUILO, ARALQUILO, HIDROXIALQUILO, AMINO, AMINOALQUILO, ALQUILAMINOALQUILO O SUS SALES FARMACEUTICAMENTE ACEPTABLES DE CATIONES ORGANICOS O INORGANICOS); EL PROCEDIMIENTO COMPRENDE: 1) CONDENSACION DE UNA O-DIAMINOTIADIAZINA CON COMPUESTOS 1,2-DICARBONILICOS, DANDO UN COMPUESTO DE FORMULA IV FORMULA 2) ALQUILACION DEL COMPUESTO IV, PARA OBTENER UN NUEVO COMPUESTO, QUE O BIEN ES SUJETO DE UNA ALQUILACION O BIEN DE UNA TRANSAMINACION. ESTOS COMPUESTOS TIENEN NOTABLES PROPIEDADES COMO DIURETICOS, BRONCODILATADORES Y ANTIAGREGANTES PLAQUETARIOS.
ES09201532A 1992-07-22 1992-07-22 Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos. Expired - Lifetime ES2048110B1 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
ES09201532A ES2048110B1 (es) 1992-07-22 1992-07-22 Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos.
AT92500133T ATE149499T1 (de) 1992-07-22 1992-10-16 N(1)-substituierte pyrazino (2,3-c>-1,2,6- thiadiazin-2,2-dioxide und ihre verwendung als arzneimittel
DE69217926T DE69217926T2 (de) 1992-07-22 1992-10-16 N(1)-Substituierte Pyrazino [2,3-c]-1,2,6-Thiadiazin-2,2-Dioxide und ihre Verwendung als Arzneimittel
ES92500133T ES2099810T3 (es) 1992-07-22 1992-10-16 2,2-dioxidos de pirazino(2,3-c)-1,2,6-tiadiazina n (1) sustituidos y su uso como productos farmaceuticos.
DK92500133.1T DK0580916T3 (da) 1992-07-22 1992-10-16 N(1)-substituerede pyrazino- 2,3-c -1,2,6-thiadiazin-2,2-dioxider samt anvendelsen heraf til farmaceutiske præparater.
EP92500133A EP0580916B1 (en) 1992-07-22 1992-10-16 N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals
ZA934926A ZA934926B (en) 1992-07-22 1993-07-08 In substituted pyrazino (2,3-c)-1,2,6-thiadiazine 2,2-dio-xides and process for the preparation thereof
NO932525A NO303874B1 (no) 1992-07-22 1993-07-12 1N-substituerte pyrazin-£2,3-C|-1,2,6-tiadiazin-2,2-dioksidforbindelser og farmasöytisk preparat inneholdende forbindelsene
AU41898/93A AU670289B2 (en) 1992-07-22 1993-07-13 1N substituted pyrazino (2,3-C)-1,2,6-thiadiazine 2,2-dioxides and process for the preparation thereof
CA002100429A CA2100429A1 (en) 1992-07-22 1993-07-13 1n substituted pyrazino [2,3-c]-1,2,6,-thiadiazine 2,2- dioxides and process for the preparation thereof
US08/093,256 US5580869A (en) 1992-07-22 1993-07-16 1N substituted pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides
NZ248196A NZ248196A (en) 1992-07-22 1993-07-20 1n-substituted-pyrazino[2,3-c]-1,2,6-thiadiazine-2,2-dioxide derivatives and preparation thereof
FI933267A FI933267A7 (fi) 1992-07-22 1993-07-20 1n-substituerade pyrazino-(2,3-c)-1,2,6-tiadiazin-2,2-dioxider och foerfarande foer framstaellning av dessa
KR1019930013761A KR100226342B1 (en) 1992-07-22 1993-07-21 1n-substituted pyrazino(2,3-c)-1,2,6-thiadiazine 2,2-dioxides and their preparation method
MX9304430A MX9304430A (es) 1992-07-22 1993-07-22 2,2-dioxidos de pirazino [2,3-c]-1, 2,6-tiadiazina n[1] sustituidos yprocedimiento para su obtencion.
JP5181435A JPH06184163A (ja) 1992-07-22 1993-07-22 １Ｎ−置換 ピラジノ〔２，３−ｃ〕−１，２，６−チアジアジン ２，２−ジオキシド誘導体類、その製造方法及び薬剤調合物
GR970401297T GR3023653T3 (en) 1992-07-22 1997-06-04 N(1) substituted pyrazino Ä2,3-cÜ-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201532A ES2048110B1 (es) 1992-07-22 1992-07-22 Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos.

Publications (2)

Publication Number Publication Date
ES2048110A1 true ES2048110A1 (es) 1994-03-01
ES2048110B1 ES2048110B1 (es) 1995-02-01

Family

ID=8277741

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09201532A Expired - Lifetime ES2048110B1 (es) 1992-07-22 1992-07-22 Procedimiento de preparacion de 2,2-dioxidos de pirazino (2,3-c)-1,2,6-tiadiazina n(1) sustituidos.
ES92500133T Expired - Lifetime ES2099810T3 (es) 1992-07-22 1992-10-16 2,2-dioxidos de pirazino(2,3-c)-1,2,6-tiadiazina n (1) sustituidos y su uso como productos farmaceuticos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES92500133T Expired - Lifetime ES2099810T3 (es) 1992-07-22 1992-10-16 2,2-dioxidos de pirazino(2,3-c)-1,2,6-tiadiazina n (1) sustituidos y su uso como productos farmaceuticos.

Country Status (16)

Country Link
US (1) US5580869A (es)
EP (1) EP0580916B1 (es)
JP (1) JPH06184163A (es)
KR (1) KR100226342B1 (es)
AT (1) ATE149499T1 (es)
AU (1) AU670289B2 (es)
CA (1) CA2100429A1 (es)
DE (1) DE69217926T2 (es)
DK (1) DK0580916T3 (es)
ES (2) ES2048110B1 (es)
FI (1) FI933267A7 (es)
GR (1) GR3023653T3 (es)
MX (1) MX9304430A (es)
NO (1) NO303874B1 (es)
NZ (1) NZ248196A (es)
ZA (1) ZA934926B (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8507559A1 (es) * 1984-03-30 1985-09-01 Consejo Superior Investigacion Procedimiento para la preparacion de 2,2-dioxidos de pirazino (2,3-c)(1,2,6)tiadiazina
ES8604193A1 (es) * 1984-06-04 1986-01-16 Chiesi Farma Spa Procedimiento para la obtencion de piperacinil-oxo-quinoli- nas
ES2009198A6 (es) * 1988-04-08 1989-09-01 Consejo Superior Investigacion Procedimiento para la obtencion de nuevos agentes colorantes pertenecientes a la familia de 2,2-dioxidos de pirazino 2,3-c -1,2,6-tiadiazina 6,7-diaril sustituidos.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2552494B2 (ja) * 1987-04-08 1996-11-13 ヘキストジャパン株式会社 イミダゾチアジアジン誘導体及びその製造法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8507559A1 (es) * 1984-03-30 1985-09-01 Consejo Superior Investigacion Procedimiento para la preparacion de 2,2-dioxidos de pirazino (2,3-c)(1,2,6)tiadiazina
ES8604193A1 (es) * 1984-06-04 1986-01-16 Chiesi Farma Spa Procedimiento para la obtencion de piperacinil-oxo-quinoli- nas
ES2009198A6 (es) * 1988-04-08 1989-09-01 Consejo Superior Investigacion Procedimiento para la obtencion de nuevos agentes colorantes pertenecientes a la familia de 2,2-dioxidos de pirazino 2,3-c -1,2,6-tiadiazina 6,7-diaril sustituidos.

Also Published As

Publication number Publication date
MX9304430A (es) 1995-01-31
KR940005637A (ko) 1994-03-22
US5580869A (en) 1996-12-03
ES2048110B1 (es) 1995-02-01
CA2100429A1 (en) 1994-01-23
NO303874B1 (no) 1998-09-14
NO932525L (no) 1994-01-24
FI933267A0 (fi) 1993-07-20
GR3023653T3 (en) 1997-09-30
AU670289B2 (en) 1996-07-11
DK0580916T3 (da) 1997-09-01
ZA934926B (en) 1994-02-09
NZ248196A (en) 1996-07-26
JPH06184163A (ja) 1994-07-05
NO932525D0 (no) 1993-07-12
EP0580916A1 (en) 1994-02-02
DE69217926D1 (de) 1997-04-10
DE69217926T2 (de) 1997-09-04
FI933267A7 (fi) 1994-01-23
ES2099810T3 (es) 1997-06-01
AU4189893A (en) 1994-02-03
ATE149499T1 (de) 1997-03-15
EP0580916B1 (en) 1997-03-05
KR100226342B1 (en) 1999-10-15

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