ES2051914T3 - Composicion para la reparacion de cartilago y hueso y metodo para su preparacion como implante de tejido oseo. - Google Patents

Composicion para la reparacion de cartilago y hueso y metodo para su preparacion como implante de tejido oseo.

Info

Publication number
ES2051914T3
ES2051914T3 ES89107552T ES89107552T ES2051914T3 ES 2051914 T3 ES2051914 T3 ES 2051914T3 ES 89107552 T ES89107552 T ES 89107552T ES 89107552 T ES89107552 T ES 89107552T ES 2051914 T3 ES2051914 T3 ES 2051914T3
Authority
ES
Spain
Prior art keywords
bone
implant
preparation
cartilage
repair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89107552T
Other languages
English (en)
Inventor
Samuel Dr Itay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/187,730 external-priority patent/US5053050A/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2051914T3 publication Critical patent/ES2051914T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/838—Marrow; spleen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/84—Bones; tendons; teeth; cartilage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

UN COMPUESTO PARA LA REGENERACION DE CARTILAGO ARTICULAR Y HUESOS POR IMPLANTE QUE COMPRENDE CELULAS QUE EXPRESAN UN FENOTIPO CONDROCITICO (80 X 10 EXP6 CEL/ML), PRINCIPALMENTE DERIVADOS DE CONDROCITOS U OSTEOBLASTOS DE ORIGEN HOMOLOGO O HETEROLOGO O CONDROCITOS HOMOLOGOS O CONDROCITOS DERIVADOS DE FIBROBLASTOS MUSCULARES HOMOLOGOS O CUALQUIER OTRA CELULA PROGENITAL DE ORIGEN MESENQUIMATICO, QUE ESTAN EMBEBIDAS EN UN VEHICULO DE INMOVILIZACION READSORVIBLE BIOLOGICO, BIOCOMPATIBLE, BIODEGRADABLE (BRIV) ADHESIVO QUE CONSISTE EN FIBRINOGENO, TROMBINA, CACL2, INHIBIDOR DE PROTEASA Y AL MENOS 10%, PREFERENTEMENTE 15 - 30%, DE SUERO, Y UN PROCESO PARA LA PREPARACION DE TAL COMPUESTO COMO IMPLANTE DE TEJIDO ESQUELETICO. UNA PORCION DEL IMPLANTE PUEDE COMPRENDER UN SEGMENTO DE HUESO O UN SUSTITUTO DE HUESO.
ES89107552T 1988-04-29 1989-04-26 Composicion para la reparacion de cartilago y hueso y metodo para su preparacion como implante de tejido oseo. Expired - Lifetime ES2051914T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/187,730 US5053050A (en) 1988-04-29 1988-04-29 Compositions for repair of cartilage and bone
US07/280,122 US4904259A (en) 1988-04-29 1988-12-05 Compositions and methods for repair of cartilage and bone

Publications (1)

Publication Number Publication Date
ES2051914T3 true ES2051914T3 (es) 1994-07-01

Family

ID=26883341

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89107552T Expired - Lifetime ES2051914T3 (es) 1988-04-29 1989-04-26 Composicion para la reparacion de cartilago y hueso y metodo para su preparacion como implante de tejido oseo.

Country Status (7)

Country Link
US (1) US4904259A (es)
EP (1) EP0339607B1 (es)
JP (1) JP2858782B2 (es)
AU (1) AU625913B2 (es)
DE (1) DE68904800T2 (es)
ES (1) ES2051914T3 (es)
IL (1) IL90075A (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2340657A1 (es) * 2010-02-19 2010-06-07 Bnac De Sang I Teixtits Procedimiento para la obtencion de un producto de ingenieria tisular orientado a la regeneracion de tejido oseo.

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US5376118A (en) * 1989-05-10 1994-12-27 United States Surgical Corporation Support material for cell impregnation
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
US20030077825A1 (en) * 1994-07-22 2003-04-24 Bhatnagar Rajendra S. Structures useful for bone engineering and methods
US5425769A (en) * 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US6990982B1 (en) * 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5197973A (en) * 1990-12-14 1993-03-30 Creative Biomolecules, Inc. Synthetic bioadhesive
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5284830A (en) * 1991-02-13 1994-02-08 The Board Of Trustees Of The Leland Stanford Junior University Thyroid-derived chondrocyte-stimulating factor
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6211146B1 (en) * 1991-03-11 2001-04-03 Curis, Inc. 60A protein-induced morphogenesis
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US6033437A (en) 1991-09-30 2000-03-07 Orbital Implant Technology Pegs for orbital implants
WO1993007913A1 (en) * 1991-10-24 1993-04-29 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
GB9125052D0 (en) * 1991-11-26 1992-01-22 Isis Innovation Culture of bone cells
US5326357A (en) * 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
KR950702434A (ko) * 1992-07-18 1995-07-29 로버트 타웁 시험관내 수정을 향상시켜주는 2성분 피브린-글루 조성물(a two component fibrin-glue composition for improving in vitro fertilization)
WO1994014390A1 (en) * 1992-12-24 1994-07-07 Orbital Implant Technology Device for orbital implant
DE69422165T2 (de) * 1993-03-30 2001-10-04 Omrix Biopharmaceuticals S.A., Bruessel/Bruxelles Zweikomponenten-fibrinkleber
EP2025353A2 (en) * 1993-04-30 2009-02-18 Massachusetts Institute of Technology Injectable polysaccharide-cell compositions
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5411885A (en) * 1993-12-17 1995-05-02 New York Blood Center, Inc. Methods for tissue embedding and tissue culturing
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
AU2435495A (en) * 1994-05-05 1995-11-29 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
AU3145795A (en) * 1994-07-26 1996-02-22 Children's Medical Center Corporation Fibrin-cell suspension for construction of new tissue
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5972703A (en) * 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
ES2266715T3 (es) * 1995-03-28 2007-03-01 Thomas Jefferson University Implantes que comprenden celulas estromales aisladas inmunologicamente y su utilizacion.
US6974571B2 (en) 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US5716616A (en) * 1995-03-28 1998-02-10 Thomas Jefferson University Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
EP0801676A2 (de) * 1995-10-20 1997-10-22 Michael Sittinger Neue künstliche gewebe, verfahren zu ihrer herstellung und ihre verwendung
US20020111695A1 (en) * 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
AU7274696A (en) 1995-11-06 1997-05-29 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
ATE295875T1 (de) * 1996-03-01 2005-06-15 Isotis Nv Verfahren zur in vitro herstellung von knochen
ATE250666T1 (de) 1996-06-04 2003-10-15 Sulzer Orthopedics Ltd Verfahren zur herstellung von knorpelgewebe und von implantaten
US5718717A (en) 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
US5759190A (en) * 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US20060025786A1 (en) * 1996-08-30 2006-02-02 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US5989269A (en) * 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US20020173806A1 (en) * 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US6475230B1 (en) * 1997-08-01 2002-11-05 Peter M. Bonutti Method and apparatus for securing a suture
EP0896825B1 (en) 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
WO1999022747A1 (en) 1997-10-30 1999-05-14 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US6197586B1 (en) * 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
US6551355B1 (en) 1998-08-14 2003-04-22 Cambridge Scientific, Inc. Tissue transplant coated with biocompatible biodegradable polymer
EP1656960A1 (en) * 1998-08-14 2006-05-17 Verigen AG Methods, instruments and materials for chondrocyte cell transplantation
SG115519A1 (en) * 1998-08-14 2005-10-28 Verigen Transplantation Serv Methods, instruments and materials for chondrocyte cell transplantation
US6190893B1 (en) * 1998-09-18 2001-02-20 Massachusetts Institute Of Technology Electroactive materials for stimulation of biological activity of bone marrow stromal cells
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
DE19926083A1 (de) * 1999-06-08 2000-12-14 Universitaetsklinikum Freiburg Biologisches Gelenkkonstrukt
US20020116063A1 (en) * 1999-08-02 2002-08-22 Bruno Giannetti Kit for chondrocyte cell transplantation
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
WO2001045595A2 (en) 1999-12-17 2001-06-28 Cartificial A/S A prosthetic device
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
WO2001082994A1 (en) * 2000-04-28 2001-11-08 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
AU2001249704A1 (en) * 2000-04-28 2001-11-12 The Regents Of The University Of California Structures useful for bone engineering and methods
US6673603B2 (en) * 2000-09-01 2004-01-06 Modex Therapeutiques, S.A. Cell paste comprising keratinocytes and fibroblasts
US7144729B2 (en) * 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
JP2002233567A (ja) * 2000-12-06 2002-08-20 Mitsuo Ochi 移植用組織等価物及びその製造方法
JP2004524839A (ja) * 2001-01-31 2004-08-19 インターフェース バイオテック エー／エス オートロガスな細胞の内植／移植方法のための哺乳動物の細胞のインビトロでの改良した培養方法
US6911202B2 (en) * 2001-02-06 2005-06-28 Abraham Amir Cosmetic repair using cartilage producing cells and medical implants coated therewith
US7476257B2 (en) * 2001-09-15 2009-01-13 Rush University Medical Center Methods to engineer stratified cartilage tissue
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
US7160725B2 (en) * 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US20030138873A1 (en) * 2002-01-22 2003-07-24 Koichi Masuda Tissue engineered cartilage for drug discovery
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040136968A1 (en) * 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) * 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US7927599B2 (en) 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US8257963B2 (en) * 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
WO2005039662A2 (en) * 2003-10-10 2005-05-06 Kw2 Implantattechnologie Gmbh Cartilage regeneration by generation of chondrons under high concentrations of magnesium
EP2335650B1 (en) 2003-12-11 2012-10-03 Isto Technologies Inc. Particulate cartilage system
KR100531922B1 (ko) * 2003-12-23 2005-11-29 주식회사 셀론텍 연골치료제 조성물 및 그 사용방법
WO2005081870A2 (en) * 2004-02-20 2005-09-09 Isto Technologies, Inc. Intervertebral disc repair, methods and devices therefor
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20090149893A1 (en) * 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
JP4279233B2 (ja) * 2004-10-25 2009-06-17 国立大学法人広島大学 間葉系組織再生誘導用シート及びその製造方法
US20060111778A1 (en) * 2004-10-29 2006-05-25 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
WO2007007062A2 (en) * 2005-07-08 2007-01-18 Depuy International Limited Cartilage repair implant
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007025290A2 (en) 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants and methods for repair, replacement and treatment of joint disease
RU2295980C1 (ru) * 2005-09-08 2007-03-27 Григорий Федорович Назаренко Имплантат для восстановления костной и/или хрящевой ткани и способ его получения
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
EP1764117A1 (en) 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US7371260B2 (en) * 2005-10-26 2008-05-13 Biomet Sports Medicine, Inc. Method and instrumentation for the preparation and transplantation of osteochondral allografts
WO2007061889A2 (en) * 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP1991282B1 (en) * 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
EP2138196A1 (en) 2006-03-20 2009-12-30 Tigenix N.V. Methods to maintain, improve and restore the cartilage phenotype of chondrocytes
US20070276506A1 (en) * 2006-05-25 2007-11-29 Biomet Manufacturing Corp. Demineralized osteochondral plug
CA2656278C (en) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
US9161967B2 (en) * 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) * 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
EP2134297B1 (en) 2007-04-12 2017-03-08 Zimmer, Inc. Apparatus for tissue repair
US8303592B2 (en) * 2007-10-05 2012-11-06 Biomet Manufacturing Corp. System for forming a tendon-bone graft
US8322256B2 (en) * 2007-10-05 2012-12-04 Biomet Manufacturing Corp. System for forming a tendon-bone graft
ES2422259T3 (es) * 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
CA2717725A1 (en) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
KR20110067035A (ko) 2008-09-09 2011-06-20 바이오미메틱 세라퓨틱스, 인크. 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법
US8790638B2 (en) * 2009-02-04 2014-07-29 Stemedica Cell Technologies, Inc. Compositions of stem cells and stem cell factors and methods for their use and manufacture
AU2010221089A1 (en) * 2009-03-05 2011-09-15 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
IL207586A0 (en) * 2010-08-12 2010-12-30 Omrix Biopharmaceuticals Ltd A fibrin based therapeutic preparation and use thereof
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
DE102011018365A1 (de) 2011-04-20 2012-10-25 Bernhard Hildebrandt Biologischer, implantierbarer Gelenkersatz
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
FR3035407B1 (fr) 2015-04-23 2022-06-17 Francais Du Sang Ets Procede de conservation de cellules, tissus ou organes en hypothermie
PE20211241A1 (es) * 2018-01-31 2021-07-09 Rokit Healthcare Inc Composicion de tinta biologica para regeneracion de cartilago, metodo de fabricacion de armazon personalizado para regeneracion de cartilago usando la misma, y armazon personalizado para regeneracion de cartilago fabricado con el metodo de fabricacion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2340657A1 (es) * 2010-02-19 2010-06-07 Bnac De Sang I Teixtits Procedimiento para la obtencion de un producto de ingenieria tisular orientado a la regeneracion de tejido oseo.
ES2340657B1 (es) * 2010-02-19 2011-01-21 Bnac De Sang I Teixtits Procedimiento para la obtencion de un producto de ingenieria tisular orientado a la regeneracion de tejido oseo.

Also Published As

Publication number Publication date
EP0339607B1 (en) 1993-02-10
IL90075A (en) 1994-08-26
EP0339607A3 (en) 1990-03-28
JPH02209811A (ja) 1990-08-21
DE68904800T2 (de) 1993-08-05
DE68904800D1 (de) 1993-03-25
JP2858782B2 (ja) 1999-02-17
EP0339607A2 (en) 1989-11-02
AU3380889A (en) 1989-11-02
US4904259A (en) 1990-02-27
AU625913B2 (en) 1992-07-16

Similar Documents

Publication Publication Date Title
Oliveira et al. Histological evaluation of bone repair with hydroxyapatite: a systematic review
US5071436A (en) Substitute bony matrix products promoting osteogenesis
Declercq et al. Isolation, proliferation and differentiation of osteoblastic cells to study cell/biomaterial interactions: comparison of different isolation techniques and source
US5585116A (en) Method of manufacture of a material for osteoplasty from a natural bone tissue and material obtained thereby
Chappard et al. Fat in bone xenografts: importance of the purification procedures on cleanliness, wettability and biocompatibility
GR3002084T3 (en) Biomaterials based on mixtures of collagen, chitosan and glycosaminoglycans, method for preparing them and their use in human medicine
Krukowski et al. Inductive specificity of mineralized bone matrix in ectopic osteoclast differentiation
CA2563082A1 (en) Cartilage repair mixture containing allograft chondrocytes
ATE265240T1 (de) Desorbierbare extrazelluläre matrix für rekonstruktion eines knorpelgewebes
EP0862617A1 (en) Tissue-engineered bone repair using cultured periosteal cells
WO1991017777A3 (en) Injectable bioactive glass compositions and methods for tissue reconstruction
KR101918908B1 (ko) 흡수성의 가교된 형태 안정적 멤브레인
US20140220142A1 (en) Composition for bone regeneration
CA2212647A1 (en) Bone graft composition
DE69733292D1 (de) Verfahren zur in vitro Herstellung von Knochen
AU4950099A (en) Material for bone reconstruction
DE68904800D1 (de) Zusammensetzung fuer das ausbessern von knorpel und knochen und verfahren fuer ihre zubereitung als skelett-gewebe-implantat.
ATE328617T1 (de) Penis-rekonstruktion
CA2376898A1 (en) Biologically active material based on an insolubilised dextran derivative and a growth factor
CN110585484A (zh) 一种骨组织用复合骨粉及其制备方法和应用
Nielsen et al. Efficacy of marine bioactive compound fucoidan for bone regeneration and implant fixation in sheep
CN112203702A (zh) 富含脱细胞化骨细胞外基质水凝胶的脱细胞化骨生物材料
DE3681429D1 (de) Knochenzement.
IL144523A0 (en) Method and compositions for healing and repair of articular cartilage
EP1331264B1 (en) Method of culturing human chondrocytes

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 339607

Country of ref document: ES