ES2052584T3 - El complejo antibiotico a10255 y factores, proceso, microorganismos para su produccion. - Google Patents

El complejo antibiotico a10255 y factores, proceso, microorganismos para su produccion.

Info

Publication number
ES2052584T3
ES2052584T3 ES87310953T ES87310953T ES2052584T3 ES 2052584 T3 ES2052584 T3 ES 2052584T3 ES 87310953 T ES87310953 T ES 87310953T ES 87310953 T ES87310953 T ES 87310953T ES 2052584 T3 ES2052584 T3 ES 2052584T3
Authority
ES
Spain
Prior art keywords
factors
microorganisms
production
antibiotic complex
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87310953T
Other languages
English (en)
Inventor
Laverne Dwaine Boeck
Marvin Martin Hoehn
Herbert Andrew Kirst
Karl Heinz Michel
Eugene Thomas Seno
Otis Webster Godfrey Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2052584T3 publication Critical patent/ES2052584T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRODUCEN LOS FACTORES B,C,E,F,G Y H DEL ANTIBIOTICO A10255 RECIENTEMENTE DESCUBIERTO, POR FERMENTACION AEROBICA SUMERGIDA DE STREPTOMYCES GARDNERI NRRL 18260, NRRL 15537, NRRL 15922, O UNA VARIANTE PRODUCTORA DEL A 10255 O UN MUTANTE DE ELLA. LOS ANTIBIOTICOS SON ACTIVOS FRENTE A UNA AMPLIA VARIEDAD DE BACTERIAS PATOGENAS Y TAMBIEN PARA MEJORAR LA EFICACIA DE UTILIZACION DE ELEMENTOS EN ANIMALES DOMESTICOS. LOS ANTIBIOTICOS SE PUEDEN USAR PARA DETECTAR LOS GENES CON TIOESTREPTORESISTENCIA EN ESPECIES DE STREPTOMYCES.
ES87310953T 1986-12-15 1987-12-14 El complejo antibiotico a10255 y factores, proceso, microorganismos para su produccion. Expired - Lifetime ES2052584T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94189486A 1986-12-15 1986-12-15
US94147386A 1986-12-15 1986-12-15

Publications (1)

Publication Number Publication Date
ES2052584T3 true ES2052584T3 (es) 1994-07-16

Family

ID=27130157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87310953T Expired - Lifetime ES2052584T3 (es) 1986-12-15 1987-12-14 El complejo antibiotico a10255 y factores, proceso, microorganismos para su produccion.

Country Status (15)

Country Link
EP (1) EP0274873B1 (es)
JP (1) JPS63258585A (es)
KR (1) KR880007553A (es)
CN (1) CN1023758C (es)
AU (1) AU604806B2 (es)
DE (1) DE3781878T2 (es)
DK (1) DK654987A (es)
ES (1) ES2052584T3 (es)
GR (1) GR3006408T3 (es)
HU (1) HU199559B (es)
IE (1) IE60394B1 (es)
IL (1) IL84819A (es)
MX (1) MX170925B (es)
NZ (1) NZ222895A (es)
PT (1) PT86364B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25145A (en) * 1986-12-15 1991-02-19 Laverne Dwaine Boeck Process for producing the a10255 complex and corresponding microorganism
US5229362A (en) * 1986-12-15 1993-07-20 Eli Lilly And Company Antibiotic A10255 complex and factors, and process and production therefor
ATE110784T1 (de) * 1987-06-19 1994-09-15 Sandoz Ag Zyklische peptolide.
IT1234197B (it) * 1988-06-14 1992-05-06 Mini Ricerca Scient Tecnolog Antibiotici ottenuti mediante coltivazione aerobica controllata dello streptomyces s.p. ncib 12629
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1355644E (pt) 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
RS20100015A (sr) 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
EP1429756B1 (en) 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
JP2006508188A (ja) 2002-11-06 2006-03-09 シェーリング　コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
BRPI0407402A (pt) 2003-02-18 2006-02-21 Incro Ltd dispositivo de bico acionável por bomba, recipiente, e, método de fabricação de um dispositivo de bico
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
BR112012004643A2 (pt) * 2009-09-02 2019-09-24 Piramal Life Scinces Ltd compostos antibióticos

Also Published As

Publication number Publication date
DK654987A (da) 1988-09-23
JPS63258585A (ja) 1988-10-26
CN1023758C (zh) 1994-02-16
IE60394B1 (en) 1994-07-13
PT86364B (pt) 1990-11-07
CN87108341A (zh) 1988-08-10
HUT49376A (en) 1989-09-28
MX170925B (es) 1993-09-22
NZ222895A (en) 1992-08-26
AU8249387A (en) 1988-07-28
EP0274873B1 (en) 1992-09-23
GR3006408T3 (es) 1993-06-21
IE873390L (en) 1988-06-15
KR880007553A (ko) 1988-08-27
EP0274873A2 (en) 1988-07-20
DE3781878T2 (de) 1993-03-11
PT86364A (en) 1988-01-01
EP0274873A3 (en) 1989-08-09
IL84819A (en) 1993-07-08
DK654987D0 (da) 1987-12-14
AU604806B2 (en) 1991-01-03
HU199559B (en) 1990-02-28
DE3781878D1 (de) 1992-10-29

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