ES2053107T3 - Derivados de fluoroamida que tienen actividad de inhibicion de elastasa de leucocitos humanos. - Google Patents
Derivados de fluoroamida que tienen actividad de inhibicion de elastasa de leucocitos humanos.Info
- Publication number
- ES2053107T3 ES2053107T3 ES90304903T ES90304903T ES2053107T3 ES 2053107 T3 ES2053107 T3 ES 2053107T3 ES 90304903 T ES90304903 T ES 90304903T ES 90304903 T ES90304903 T ES 90304903T ES 2053107 T3 ES2053107 T3 ES 2053107T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- human leukocyte
- leukocyte elastase
- fluoroamide
- inhibit activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 title abstract 4
- 102100033174 Neutrophil elastase Human genes 0.000 title abstract 4
- MDQRDWAGHRLBPA-UHFFFAOYSA-N fluoroamine Chemical class FN MDQRDWAGHRLBPA-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
EL PRESENTE INVENTO SE REFIERE A CIERTOS DERIVADOS FLUORO AMIDOS DE LA FORMULA GENERAL (I) QUE SON INHIBIDORES DE LA ELASTASA DE LEUCOCITO HUMANO HACIENDOLOS UTILES CUANDO SE DESEA DICHA INHIBICION, COMO HERRAMIENTAS DE INVESTIGACION EN ESTUDIOS FARMACOLOGICOS Y DIAGNOSTICOS Y EN TRATAMIENTOS EN ENFERMEDADES DE MAMIFEROS EN LAS CUALES ESTA IMPLICADA LA ELASTASA DEL LEUCOCITO HUMANO, INCLUYENDO EL TRATAMIENTO DE ENFERMEDADES DE TEJIDOS DEGENERATIVOS TALES COMO EL ENFISEMA PULMONAR. EL INVENTO TAMBIEN INCLUYE INTERMEDIARIOS UTILES EN LA SINTESIS DE ESTOS DERIVATIVOS FLUORO AMIDOS, UN PROCESO PAR SU PREPARACION, LOS COMPUESTOS FARMACEUTICOS QUE CONTIENEN DICHOS DERIVATIVOS PEPTIDOS Y METODOS PARA SU USO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898910547A GB8910547D0 (en) | 1989-05-08 | 1989-05-08 | Substituted ketones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053107T3 true ES2053107T3 (es) | 1994-07-16 |
Family
ID=10656399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90304903T Expired - Lifetime ES2053107T3 (es) | 1989-05-08 | 1990-05-04 | Derivados de fluoroamida que tienen actividad de inhibicion de elastasa de leucocitos humanos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5270301A (es) |
| EP (1) | EP0397427B1 (es) |
| JP (1) | JP2872748B2 (es) |
| AT (1) | ATE105302T1 (es) |
| AU (1) | AU622316B2 (es) |
| CA (1) | CA2016209A1 (es) |
| DE (1) | DE69008615T2 (es) |
| DK (1) | DK0397427T3 (es) |
| ES (1) | ES2053107T3 (es) |
| GB (1) | GB8910547D0 (es) |
| IE (1) | IE63573B1 (es) |
| NZ (1) | NZ233514A (es) |
| ZA (1) | ZA903343B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
| GB8910550D0 (en) * | 1989-05-08 | 1989-06-21 | Ici America Inc | Substituted amides |
| CA2021660A1 (en) * | 1989-07-26 | 1991-01-27 | Philippe Bey | Peptidase inhibitors |
| US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
| IL108031A0 (en) * | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
| US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
| WO2004065383A2 (en) * | 2003-01-16 | 2004-08-05 | Teva Pharmaceutical Industries Ltd. | Novel synthesis of irbesartan |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256761A (en) * | 1979-07-13 | 1981-03-17 | Usv Pharmaceutical Corporation | Antihypertensive amides |
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| EP0204571B1 (en) * | 1985-06-07 | 1992-01-22 | Ici Americas Inc. | Selected difluoro derivatives |
| GB8613704D0 (en) * | 1986-06-05 | 1986-07-09 | Ici America Inc | Difluoro keto compounds |
| GB8711748D0 (en) * | 1986-06-05 | 1987-06-24 | Ici America Inc | Difluoro keto compounds |
| EP0276101A3 (en) * | 1987-01-19 | 1989-11-23 | Ici Americas Inc. | Substituted peptide derivatives |
| GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
| EP0369391A3 (en) * | 1988-11-15 | 1991-09-25 | Boehringer Ingelheim Pharmaceuticals Inc. | N-substituted amides |
| GB8910550D0 (en) * | 1989-05-08 | 1989-06-21 | Ici America Inc | Substituted amides |
-
1989
- 1989-05-08 GB GB898910547A patent/GB8910547D0/en active Pending
-
1990
- 1990-05-01 AU AU54565/90A patent/AU622316B2/en not_active Ceased
- 1990-05-01 NZ NZ233514A patent/NZ233514A/en unknown
- 1990-05-02 ZA ZA903343A patent/ZA903343B/xx unknown
- 1990-05-04 AT AT9090304903T patent/ATE105302T1/de not_active IP Right Cessation
- 1990-05-04 DE DE69008615T patent/DE69008615T2/de not_active Expired - Fee Related
- 1990-05-04 EP EP90304903A patent/EP0397427B1/en not_active Expired - Lifetime
- 1990-05-04 DK DK90304903.9T patent/DK0397427T3/da active
- 1990-05-04 ES ES90304903T patent/ES2053107T3/es not_active Expired - Lifetime
- 1990-05-07 IE IE165390A patent/IE63573B1/en not_active IP Right Cessation
- 1990-05-07 CA CA002016209A patent/CA2016209A1/en not_active Abandoned
- 1990-05-07 US US07/519,618 patent/US5270301A/en not_active Expired - Fee Related
- 1990-05-08 JP JP2118526A patent/JP2872748B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5456590A (en) | 1990-11-15 |
| US5270301A (en) | 1993-12-14 |
| IE63573B1 (en) | 1995-05-17 |
| EP0397427A1 (en) | 1990-11-14 |
| CA2016209A1 (en) | 1990-11-08 |
| IE901653L (en) | 1990-11-08 |
| GB8910547D0 (en) | 1989-06-21 |
| EP0397427B1 (en) | 1994-05-04 |
| ATE105302T1 (de) | 1994-05-15 |
| DK0397427T3 (da) | 1994-06-06 |
| ZA903343B (en) | 1991-01-30 |
| DE69008615D1 (de) | 1994-06-09 |
| DE69008615T2 (de) | 1994-08-18 |
| AU622316B2 (en) | 1992-04-02 |
| NZ233514A (en) | 1993-01-27 |
| JPH0356496A (ja) | 1991-03-12 |
| JP2872748B2 (ja) | 1999-03-24 |
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| ATE197043T1 (de) | Pyrimidinyl-essigsäureamide als elastase inhibitoren | |
| ATE167481T1 (de) | Lactampeptide mit hfl inhibierender aktivität | |
| TW262475B (en) | Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them | |
| AU3959693A (en) | Alpha-aminoboronic acid peptides and their use as elastase inhibitors | |
| NO943911L (no) | Pyrimidinyl-acetamider som elastaseinhibitorer | |
| FI944802A0 (fi) | HLE-proteiinien aktiivisuutta inhiboivat laktaamidipeptidit | |
| FI946202A0 (fi) | Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan | |
| ATE105302T1 (de) | Fluoramid-derivate mit hemmender aktivitaet gegen menschliche leukozytenelastase. | |
| GB9211783D0 (en) | Amide derivatives | |
| DK0399688T3 (da) | Trifluorketopeptidderivater, som er nyttige som human leukocyt-elastaseinhibitorer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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