ES2053430T3 - Procedimiento para la obtencion de derivados de aminoacidos. - Google Patents

Procedimiento para la obtencion de derivados de aminoacidos.

Info

Publication number
ES2053430T3
ES2053430T3 ES86115175T ES86115175T ES2053430T3 ES 2053430 T3 ES2053430 T3 ES 2053430T3 ES 86115175 T ES86115175 T ES 86115175T ES 86115175 T ES86115175 T ES 86115175T ES 2053430 T3 ES2053430 T3 ES 2053430T3
Authority
ES
Spain
Prior art keywords
amino acid
acid derivatives
procedure
obtaining amino
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86115175T
Other languages
English (en)
Inventor
Peter Raddatz
Guenter Hoelzemann
Claus J Schmitges
Klaus Otto Minck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2053430T3 publication Critical patent/ES2053430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVOS DERIVADOS DE AMINOACIDOS DE LA FORMULA I X-2-NR2-CHR3-CHR4-(CHR5)N-CO- B-D, DONDE X,Z,R2,R3,R4,R5,B,D Y N TIENEN EL SIGNIFICADO DADO EN LA REIVINDICACION DE PATENTE 1, Y SUS SALES INHIBEN LA ACTIVIDAD DE LA RENINA DEL PLASMA HUMANO.
ES86115175T 1985-11-15 1986-11-01 Procedimiento para la obtencion de derivados de aminoacidos. Expired - Lifetime ES2053430T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853540495 DE3540495A1 (de) 1985-11-15 1985-11-15 Aminosaeurederivate

Publications (1)

Publication Number Publication Date
ES2053430T3 true ES2053430T3 (es) 1994-08-01

Family

ID=6286038

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86115175T Expired - Lifetime ES2053430T3 (es) 1985-11-15 1986-11-01 Procedimiento para la obtencion de derivados de aminoacidos.

Country Status (10)

Country Link
US (1) US4721776A (es)
EP (1) EP0222283B1 (es)
JP (1) JPS62187488A (es)
AT (1) ATE84043T1 (es)
AU (1) AU588929B2 (es)
CA (1) CA1298034C (es)
DE (2) DE3540495A1 (es)
ES (1) ES2053430T3 (es)
HU (1) HU205139B (es)
ZA (1) ZA868665B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826958A (en) * 1984-12-14 1989-05-02 Abbott Laboratories Renin inhibiting compounds
DE3638425A1 (de) * 1986-11-11 1988-05-19 Merck Patent Gmbh Aminosaeurederivate
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
US5162527A (en) * 1987-10-26 1992-11-10 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
EP0314060A3 (en) * 1987-10-26 1991-06-19 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
US5138061A (en) * 1989-08-04 1992-08-11 Biochem Pharma Inc. Thioacylating reagents
US5457180A (en) * 1989-08-04 1995-10-10 Biochem Pharma Inc. Methods for producing linear thiopeptides using an amino acid ortho amino thioanilide compound
US5182266A (en) * 1990-01-31 1993-01-26 Abbott Laboratories Method for treating renal disease
IL96942A (en) * 1990-01-31 1995-01-24 Abbott Lab A pharmaceutical mixture containing a history of amide prevents renin
DE69329425T2 (de) * 1992-12-16 2001-01-18 Basf Ag Dolastatin analog

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4609643A (en) * 1980-08-06 1986-09-02 Aktiebolaget Hassle Renin inhibitors, treatments and dipeptide synthesis
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
US4650661A (en) * 1982-09-15 1987-03-17 Aktiebolaget Hassle Enzyme inhibitors
US4668770A (en) * 1982-12-27 1987-05-26 Merck & Co., Inc. Renin inhibitory tripeptides
EP0118223A1 (en) * 1983-02-07 1984-09-12 Aktiebolaget Hässle Enzyme inhibitors
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DK110285A (da) * 1984-03-12 1985-09-13 Pfizer Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
US4645759A (en) * 1984-06-22 1987-02-24 Abbott Laboratories Renin inhibiting compounds
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
US4665055A (en) * 1985-06-17 1987-05-12 Merck & Co., Inc. Peptide renin inhibitors

Also Published As

Publication number Publication date
DE3687405D1 (de) 1993-02-11
DE3540495A1 (de) 1987-05-21
US4721776A (en) 1988-01-26
ZA868665B (en) 1987-06-24
EP0222283A2 (de) 1987-05-20
CA1298034C (en) 1992-03-24
HUT45081A (en) 1988-05-30
EP0222283A3 (en) 1989-09-06
AU6462986A (en) 1987-05-21
ATE84043T1 (de) 1993-01-15
AU588929B2 (en) 1989-09-28
HU205139B (en) 1992-03-30
EP0222283B1 (de) 1992-12-30
JPS62187488A (ja) 1987-08-15

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