ES2053530T3 - Compuestos macrolidos. - Google Patents

Compuestos macrolidos.

Info

Publication number
ES2053530T3
ES2053530T3 ES87302097T ES87302097T ES2053530T3 ES 2053530 T3 ES2053530 T3 ES 2053530T3 ES 87302097 T ES87302097 T ES 87302097T ES 87302097 T ES87302097 T ES 87302097T ES 2053530 T3 ES2053530 T3 ES 2053530T3
Authority
ES
Spain
Prior art keywords
group
methyl
metoxi
compounds
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87302097T
Other languages
English (en)
Inventor
Brian A M Rudd
Richard A Fletton
John B Ward
David Noble
Neil Porter
Gordon C Lawrence
Hazel M Noble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868606111A external-priority patent/GB8606111D0/en
Priority claimed from GB868606114A external-priority patent/GB8606114D0/en
Priority claimed from GB868606112A external-priority patent/GB8606112D0/en
Priority claimed from GB868606110A external-priority patent/GB8606110D0/en
Priority claimed from GB868606115A external-priority patent/GB8606115D0/en
Priority claimed from GB868606113A external-priority patent/GB8606113D0/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2053530T3 publication Critical patent/ES2053530T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN LA QUE R1 REPRESENTA UN GRUPO METILO; R2 REPRESENTA TAMBIEN UN GRUPO METILO; R3 ES UN GRUPO METILO ETILO O ISOPROPILO Y A ES UN ANILLO A) O B), SIENDO R4 UN OH O UN GRUPO METOXI Y R5 UN H, O BIEN R4 Y R5 JUNTO CON EL ATOMO DE C AL QUE ESTAN UNIDOS FORMAN UN GRUPO C=0 Y ENTONCES R2 PUEDE SER TAMBIEN UN GRUPO ALDEHIDO; O BIEN R2 ES UN GRUPO HIDROXIMETILO Y A ES UN ANILLO C), (SIENDO R6 UN H O OH); O BIEN LA PARTE INFERIOR DEL COMPUESTO (I) QUE IMPLICA A R2 Y A ES EL GRUPO D), (SIENDO R7=OH O UN GRUPO METOXI Y Z ES CHOH O C=O) O EL GRUPO E) SIENDO R1=H Y R8=OH O UN GRUPO METOXI; CON LA CONDICION DE QUE CUANDO R2 ES UN GRUPO METILO Y R4 UN GRUPO METOXI, R3 NO PUEDE SER METILO NI ISOPROPILO Y CUANDO R2 ES UN GRUPO HIDROXIMETILO Y R6 UN OH, R3 NO PUEDE SER UN GRUPO METILO. LOS COMPUESTOS DE LA INVENCION TIENEN ACTIVIDAD ANTIPARASITARIA.
ES87302097T 1986-03-12 1987-03-11 Compuestos macrolidos. Expired - Lifetime ES2053530T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB868606111A GB8606111D0 (en) 1986-03-12 1986-03-12 Chemical compounds
GB868606114A GB8606114D0 (en) 1986-03-12 1986-03-12 Chemical compounds
GB868606112A GB8606112D0 (en) 1986-03-12 1986-03-12 Chemical compounds
GB868606110A GB8606110D0 (en) 1986-03-12 1986-03-12 Chemical compounds
GB868606115A GB8606115D0 (en) 1986-03-12 1986-03-12 Chemical compounds
GB868606113A GB8606113D0 (en) 1986-03-12 1986-03-12 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2053530T3 true ES2053530T3 (es) 1994-08-01

Family

ID=27546926

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87302097T Expired - Lifetime ES2053530T3 (es) 1986-03-12 1987-03-11 Compuestos macrolidos.

Country Status (5)

Country Link
EP (1) EP0242052B1 (es)
JP (1) JPH0794457B2 (es)
DE (1) DE3785480T2 (es)
ES (1) ES2053530T3 (es)
HK (1) HK39295A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
US5312753A (en) * 1992-03-23 1994-05-17 Merck & Co., Inc. Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions
JP2855181B2 (ja) * 1993-12-10 1999-02-10 敏雄 鈴木 松類の枯損防止用組成物及び防止方法
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK165119C (da) * 1984-06-05 1993-03-01 American Cyanamid Co Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling

Also Published As

Publication number Publication date
JPS62272985A (ja) 1987-11-27
HK39295A (en) 1995-03-24
DE3785480T2 (de) 1993-08-26
EP0242052B1 (en) 1993-04-21
EP0242052A2 (en) 1987-10-21
EP0242052A3 (en) 1988-01-07
DE3785480D1 (de) 1993-05-27
JPH0794457B2 (ja) 1995-10-11

Similar Documents

Publication Publication Date Title
IT8024820A0 (it) Composizioni germicide a base di iodio dotate di maggiore stabilita'.
ATE116656T1 (de) Säurebeständige dideoxynucleoside, wirksam gegen den hiv-virus.
BG33732A3 (bg) Хербицидно средство
BG28556A3 (bg) Фунгицидно средство
DK266179A (da) 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanforbindelser eller syreadditionssalte deraf fremgangsmaade til deres fremstilling samt deres anvendelse
AR246509A1 (es) Una cetimina, su preparacion y un agente de entrecruzamiento que la contiene.
ES2075850T3 (es) Derivados de beta-lactama.
JPS53119844A (en) Optically active amino acid-mandelic acid complexes and theire preparation
ATE82960T1 (de) Zusammenstellungen fuer die permanente aenderung der haarstruktur.
BG30762A3 (en) Herbicide means
ES2070238T3 (es) Emulsion de lipidos que contiene un analogo de prostaglandina.
BG29267A3 (en) Fungicgde means
AR246851A1 (es) Composicion herbicida.
SE8006953L (sv) Heterocykliska foreningar
BG28236A3 (en) Insecticide composition
BG31463A3 (bg) Инсектицидно средство
BG32415A3 (en) Fungicide means
BG28551A3 (bg) Фунгицидно средство
BG32264A3 (en) Fungicide means
BG28238A3 (en) Insekticide means
ES8300096A1 (es) "un procedimiento para preparar derivados de halofenil-piridil-alilamina".
BG34607A3 (bg) Фунгицидно средство
JPS535233A (en) White line compositions for artificial grass
GB2021586A (en) 1,2,4-Triazolidin-3-ones (and -thiones)
ES2053257T3 (es) Derivados de pradimicina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 242052

Country of ref document: ES