ES2053589T3 - Nuevos compuestos de cistina, su fabricacion y empleo. - Google Patents
Nuevos compuestos de cistina, su fabricacion y empleo.Info
- Publication number
- ES2053589T3 ES2053589T3 ES87890244T ES87890244T ES2053589T3 ES 2053589 T3 ES2053589 T3 ES 2053589T3 ES 87890244 T ES87890244 T ES 87890244T ES 87890244 T ES87890244 T ES 87890244T ES 2053589 T3 ES2053589 T3 ES 2053589T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- amino acid
- organic
- independently
- another
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical class OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 6
- 229940024606 amino acid Drugs 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 6
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000008575 L-amino acids Chemical class 0.000 abstract 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 2
- -1 acetyl- Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229960003104 ornithine Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 229930064664 L-arginine Natural products 0.000 abstract 1
- 235000014852 L-arginine Nutrition 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical class [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000009697 arginine Nutrition 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 229960002885 histidine Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 235000013930 proline Nutrition 0.000 abstract 1
- 235000004400 serine Nutrition 0.000 abstract 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract 1
- 235000008521 threonine Nutrition 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 235000014393 valine Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
SE PRESENTAN NUEVOS COMPUESTOS DE CISTINA DE FORMULA GENERAL (I), EN LA QUE AS (AMINOACIDOS) INDEPENDIENTEMENTE UNO DE OTRO, SIGNIFICA L-AMINOACIDO, EN ESPECIAL GLICINA, ALANINA, PROLINA, TRONINA, SERINA, VALINA, ARGININA, LISINA U ORNITINA, LOS R1 SON, INDEPENDIENTEMENTE UNO DE OTRO UN RESTO ACILO DE UN ACIDO ORGANICO CON 2-5 ATOMOS DE C, PREFERENTEMENTE ACETILO, PROPIONILO, SUCCINILO O HIDROXISUCCINILO, O UN L-AMINOACIDO, QUE SE UNE CON EL GRUPO AMINO DEL AMINOACIDO AS SOBRE SU GRUPO CARBOXILO DE TIPO AMIDA, LOS AMINOACIDOS PREFERIDOS CITADOS PARA AS TAMBIEN SE PREFIEREN PARA LOS AMINOACIDOS DE R1, O LOS DE R1 JUNTOS FORMAN EL RESTO ACILO DE UN ACIDO DICARBOXILICO ORGANICO CON PREFERENCIA AL RESTO DE ACIDO SUCCINICO O MALICO. LOS R2,INDEPENDIENTEMENTE UNO DE OTRO SON UN RESTO ALCOXI CON 1-4 ATOMOS DE C, CON PREFERENCIA A METOXI O ETOXI, UN RESTO HIDROXI, DE DONDE EN EL CASO DEL SIGNIFICADO DE R2= GRUPOS CARBOXILO CON H PUEDEN EXISTIR COMO TALES O COMO SAL ORGANICA O INORGANICA, PREFERENTEMENTE CON NAOH O KOH, BASES ORGANICAS O AMINOACIDOS BASICOA COMO L-LISINA, L-ORNITINA, L-ARGININA O L-HISTIDINA. PROCEDIMIENTO PARA SU OBTENCION Y COMPOSICION DE NUTRIENTES OBTENIDOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0298086A AT402931B (de) | 1986-11-07 | 1986-11-07 | Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053589T3 true ES2053589T3 (es) | 1994-08-01 |
Family
ID=3543430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87890244T Expired - Lifetime ES2053589T3 (es) | 1986-11-07 | 1987-11-04 | Nuevos compuestos de cistina, su fabricacion y empleo. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4801579A (es) |
| EP (1) | EP0267179B1 (es) |
| JP (1) | JPS63233999A (es) |
| AT (2) | AT402931B (es) |
| DE (1) | DE3784215D1 (es) |
| ES (1) | ES2053589T3 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5102871A (en) * | 1989-04-24 | 1992-04-07 | Kyowa Hakko Kogyo Co., Ltd. | Nutrient composition |
| SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
| DE602005025510D1 (de) * | 2004-09-09 | 2011-02-03 | Nestec Sa | Herstellungsmethoden für nahrungsmittel mit verbesserter qualität |
| US8685956B2 (en) * | 2009-09-16 | 2014-04-01 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for reducing the risk of agent-induced liver toxicity |
| CN114767562B (zh) | 2016-12-21 | 2024-05-10 | 联合利华知识产权控股有限公司 | 具有氨基酸和烟酰胺化合物的局部皮肤增亮添加剂和组合物 |
| EA201991003A1 (ru) | 2016-12-21 | 2019-12-30 | Юнилевер Н.В. | Композиции для личной гигиены, содержащие малорастворимые соединения |
| JP7082623B2 (ja) | 2016-12-21 | 2022-06-08 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | シスチンを有するパーソナルケア用組成物 |
| EP3558246B1 (en) | 2016-12-21 | 2021-10-20 | Unilever IP Holdings B.V. | Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1768777A1 (de) * | 1968-06-28 | 1971-07-08 | Hoechst Ag | Cysteinhaltige Peptide und deren Derivate und ein Verfahren zu ihrer Herstellung |
| DE1917939C3 (de) * | 1969-04-09 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung cystinhaltiger Peptide |
| CH517705A (de) * | 1969-12-16 | 1972-01-15 | Ciba Geigy Ag | Verfahren zur Herstellung von Cystin-haltigen Peptiden |
| BE785933A (fr) * | 1971-07-07 | 1973-01-08 | Ciba Geigy | Procede de preparation de peptides contenant de la cystine |
| SE399880B (sv) * | 1973-05-24 | 1978-03-06 | Ciba Geigy Ag | Sett att framstella peptider, som innehaller mer en en disulfidbindning |
| US4284624A (en) * | 1980-05-02 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Mixed disulfides |
| JPS62195356A (ja) * | 1986-02-20 | 1987-08-28 | Seiwa Kasei:Kk | シスチン誘導体及びその塩 |
| ES2039402T3 (es) * | 1986-10-24 | 1993-10-01 | Pfrimmer Kabi Gmbh & Co. Kg | Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral. |
-
1986
- 1986-11-07 AT AT0298086A patent/AT402931B/de not_active IP Right Cessation
-
1987
- 1987-11-02 US US07/115,796 patent/US4801579A/en not_active Expired - Lifetime
- 1987-11-04 AT AT87890244T patent/ATE85798T1/de active
- 1987-11-04 EP EP87890244A patent/EP0267179B1/de not_active Expired - Lifetime
- 1987-11-04 ES ES87890244T patent/ES2053589T3/es not_active Expired - Lifetime
- 1987-11-04 DE DE8787890244T patent/DE3784215D1/de not_active Expired - Lifetime
- 1987-11-06 JP JP62281952A patent/JPS63233999A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4801579A (en) | 1989-01-31 |
| EP0267179A3 (en) | 1990-02-28 |
| JPS63233999A (ja) | 1988-09-29 |
| DE3784215D1 (de) | 1993-03-25 |
| EP0267179B1 (de) | 1993-02-17 |
| ATA298086A (de) | 1997-02-15 |
| ATE85798T1 (de) | 1993-03-15 |
| EP0267179A2 (de) | 1988-05-11 |
| AT402931B (de) | 1997-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO911787D0 (no) | Peptidaminer samt fremgangsmaate for fremstilling derav. | |
| IE801342L (en) | Peptides | |
| DE3679396D1 (de) | Synthetisches peptid mit menschlicher interleukin 1-wirksamkeit. | |
| ATE86964T1 (de) | Malonsaeurederivate und ihre synthesemethoden. | |
| AU2009292741B2 (en) | Dendrimeric compounds comprising amino acids, hyperbranched core compound, process for preparation of dendrimeric compounds comprising amino acids and hyperbranched core compound, and use thereof | |
| ES8200861A1 (es) | Procedimiento para la obtencion de acilpeptidos | |
| GR3018691T3 (en) | Amino acids, peptides or derivatives thereof coupled to fats | |
| IE781227L (en) | New peptide derivatives. | |
| DE3784215D1 (de) | Neue cystinverbindungen, ihre herstellung und verwendung. | |
| GB1494603A (en) | N-(perfluoroalkanoyl)-n-phosphonomethyl glycine compounds | |
| KR900009694A (ko) | 급속히 분해가능한, hiv 프로테아제용 기질 | |
| ES8706622A1 (es) | Procedimiento para preparar alfa-aminoacidos sustituidos | |
| ES2034324T3 (es) | Procedimiento de sintesis industrial de alfa amino diacidos n alquilados o de esteres de ellos. | |
| SE327779B (es) | ||
| SE8406554D0 (sv) | New gonadoliberin derivatives and process for the preparation thereof | |
| KR890003404A (ko) | 수식형 tPA 함유 주사용 조성물 | |
| IE881710L (en) | (2-Cyano-2-oximinoacetyl)-amino acid derivatives | |
| ATE118008T1 (de) | Verfahren zur herstellung von aminomethanphosphonsäure und aminomethyl- phosphinsäuren. | |
| DE59408751D1 (de) | Verfahren zur Herstellung von Fettsäureamiden und ihre Verwendung | |
| IT1317732B1 (it) | Composti ad attivita' antiossidante, composizioni utili qualiintegratori alimentari che li contengono e procedimento per | |
| GB1058947A (es) | ||
| ATE101616T1 (de) | Verfahren zur herstellung von dipeptiden. | |
| ES2019545A6 (es) | Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos. | |
| BG49274A3 (bg) | Метод за получаване на естери на l-аминодикарбонова киселина | |
| JPS5539713A (en) | Rhodotorucine a and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 267179 Country of ref document: ES |