ES2053618T3 - Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion. - Google Patents
Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion.Info
- Publication number
- ES2053618T3 ES2053618T3 ES88108004T ES88108004T ES2053618T3 ES 2053618 T3 ES2053618 T3 ES 2053618T3 ES 88108004 T ES88108004 T ES 88108004T ES 88108004 T ES88108004 T ES 88108004T ES 2053618 T3 ES2053618 T3 ES 2053618T3
- Authority
- ES
- Spain
- Prior art keywords
- endotoxin
- whole cough
- toxoid
- production
- cough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002158 endotoxin Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 201000005702 Pertussis Diseases 0.000 abstract 2
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 229940085991 phosphate ion Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION OFRECE UN METODO CLARO Y EFICIENTE PARA ELIMINAR LA ENDOTOXINA DE LA TOS FERINA CARACTERIZADO PORQUE A UN FLUIDO QUE CONTIENE LA FRACCION ANTIINFECCIOSA Y LA ENDOTOXINA DE CEPAS DE BORDOTELLA PERTOSSIS FASE I SE LE APORTA ION CALCIO EN PRESENCIA DE UN EXCESO DE ION FOSFATO ANTES DE LA CENTRIFUGACION POR ZONAS. TAMBIEN SE PRESENTA UN TOXOIDE DE TOS FERINA CUYO CONTENIDO DE ENDOTOXINA POR CADA MICROGRAMO DE NITROGENO PROTEINICO NO ES MAYOR DE 0,5 NG. TAMBIEN SE PRESENTA SU METODO DE OBTENCION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12639487 | 1987-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053618T3 true ES2053618T3 (es) | 1994-08-01 |
Family
ID=14934054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88108004T Expired - Lifetime ES2053618T3 (es) | 1987-05-22 | 1988-05-19 | Metodo para separar la endotoxina de la tos ferina, un toxoide de la tos ferina y su produccion. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5101019A (es) |
| EP (1) | EP0291968B1 (es) |
| JP (1) | JPH0834742B2 (es) |
| KR (1) | KR970002614B1 (es) |
| CN (1) | CN1019979C (es) |
| AT (1) | ATE84971T1 (es) |
| CA (1) | CA1326444C (es) |
| DE (1) | DE3877818T2 (es) |
| DK (1) | DK273588A (es) |
| ES (1) | ES2053618T3 (es) |
| GR (1) | GR3007238T3 (es) |
| HU (1) | HU200194B (es) |
| NO (1) | NO178423C (es) |
| RU (1) | RU2089216C1 (es) |
| UA (1) | UA12647A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU667858B2 (en) * | 1991-11-15 | 1996-04-18 | Smithkline Beecham Corporation | Gram-negative bacterial vaccines |
| CA2188424A1 (en) * | 1994-04-28 | 1995-11-09 | Akihiro Suehara | Method of separating protective components of bordetella pertussis |
| RU2130778C1 (ru) * | 1998-07-31 | 1999-05-27 | Акционерное общество закрытого типа НПК "Комбиотех Лтд" | Комбинированная вакцина для иммунопрофилактики вирусного гепатита в, столбняка, дифтерии и коклюша |
| SE0003958D0 (sv) | 2000-10-31 | 2000-10-31 | Biogaia Fermentation Ab | Method for growth of microorganisms |
| CN102448490B (zh) * | 2009-04-28 | 2015-05-13 | 国家健康与医学研究院 | 用于预防或治疗过敏原引起的气道疾病的疫苗 |
| DE102009043932A1 (de) | 2009-09-02 | 2011-03-10 | Stükerjürgen, Ferdinand | Wickelrohr mit erhöhter Stabilität |
| GB201011968D0 (en) * | 2010-07-16 | 2010-09-01 | Secr Defence | Toxoiding method |
| CN103454235B (zh) * | 2013-09-13 | 2016-04-20 | 广州康盛生物科技有限公司 | 一种超声辅助测定血浆中细菌内毒素含量的方法 |
| CN104017792A (zh) * | 2014-06-26 | 2014-09-03 | 上海第一生化药业有限公司 | 一种去除胰蛋白酶中的内毒素的方法 |
| CN104031900A (zh) * | 2014-06-26 | 2014-09-10 | 上海第一生化药业有限公司 | 一种去除多肽中的内毒素的方法 |
| CN104017793A (zh) * | 2014-06-26 | 2014-09-03 | 上海第一生化药业有限公司 | 一种去除糜蛋白酶中的内毒素的方法 |
| US20190177588A1 (en) * | 2017-12-12 | 2019-06-13 | Xotramorphic LLC | Compositions, Methods, and Systems For Producing Flocculent Materials for Special Effects |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1604134A (es) * | 1967-09-26 | 1971-07-12 | ||
| US3978209A (en) * | 1975-03-24 | 1976-08-31 | Merck & Co., Inc. | Endotoxin free meningococcus polysaccharides |
| US4220717A (en) * | 1977-12-22 | 1980-09-02 | American Cyanamid Company | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
| JPS5750925A (en) * | 1980-09-12 | 1982-03-25 | Takeda Chem Ind Ltd | Preparation of pertussis toxoid |
| US4705686A (en) * | 1986-05-09 | 1987-11-10 | American Cyanamid | Process for the preparation of acellular Bordetalla pertussis vaccine |
| CA1337859C (en) * | 1987-04-24 | 1996-01-02 | Masashi Chazono | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
-
1988
- 1988-05-16 US US07/194,216 patent/US5101019A/en not_active Expired - Fee Related
- 1988-05-18 CA CA000567092A patent/CA1326444C/en not_active Expired - Fee Related
- 1988-05-19 EP EP88108004A patent/EP0291968B1/en not_active Expired - Lifetime
- 1988-05-19 DE DE8888108004T patent/DE3877818T2/de not_active Expired - Fee Related
- 1988-05-19 DK DK273588A patent/DK273588A/da not_active Application Discontinuation
- 1988-05-19 AT AT88108004T patent/ATE84971T1/de not_active IP Right Cessation
- 1988-05-19 ES ES88108004T patent/ES2053618T3/es not_active Expired - Lifetime
- 1988-05-20 NO NO882208A patent/NO178423C/no not_active IP Right Cessation
- 1988-05-20 JP JP63124066A patent/JPH0834742B2/ja not_active Expired - Lifetime
- 1988-05-20 HU HU882602A patent/HU200194B/hu not_active IP Right Cessation
- 1988-05-20 UA UA4355806A patent/UA12647A1/uk unknown
- 1988-05-20 RU SU884355806A patent/RU2089216C1/ru active
- 1988-05-21 KR KR1019880006053A patent/KR970002614B1/ko not_active Expired - Fee Related
- 1988-05-23 CN CN88103075A patent/CN1019979C/zh not_active Expired - Fee Related
-
1993
- 1993-03-05 GR GR930400458T patent/GR3007238T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1326444C (en) | 1994-01-25 |
| HU200194B (en) | 1990-04-28 |
| CN1019979C (zh) | 1993-03-03 |
| DK273588A (da) | 1988-11-23 |
| JPH0834742B2 (ja) | 1996-03-29 |
| NO178423C (no) | 1996-03-27 |
| JPS6452726A (en) | 1989-02-28 |
| KR970002614B1 (ko) | 1997-03-06 |
| ATE84971T1 (de) | 1993-02-15 |
| NO178423B (no) | 1995-12-18 |
| GR3007238T3 (es) | 1993-07-30 |
| UA12647A1 (uk) | 1997-02-28 |
| EP0291968A1 (en) | 1988-11-23 |
| US5101019A (en) | 1992-03-31 |
| HUT47602A (en) | 1989-03-28 |
| DK273588D0 (da) | 1988-05-19 |
| KR880013573A (ko) | 1988-12-21 |
| EP0291968B1 (en) | 1993-01-27 |
| CN88103075A (zh) | 1988-12-21 |
| NO882208D0 (no) | 1988-05-20 |
| HU896222D0 (en) | 1990-02-28 |
| DE3877818D1 (de) | 1993-03-11 |
| NO882208L (no) | 1988-11-23 |
| RU2089216C1 (ru) | 1997-09-10 |
| DE3877818T2 (de) | 1993-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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