ES2053719T3 - Dimetilvermectinas no naturales y procedimiento para su preparacion. - Google Patents

Dimetilvermectinas no naturales y procedimiento para su preparacion.

Info

Publication number
ES2053719T3
ES2053719T3 ES88300426T ES88300426T ES2053719T3 ES 2053719 T3 ES2053719 T3 ES 2053719T3 ES 88300426 T ES88300426 T ES 88300426T ES 88300426 T ES88300426 T ES 88300426T ES 2053719 T3 ES2053719 T3 ES 2053719T3
Authority
ES
Spain
Prior art keywords
natural
procedure
dimetilvermectinas
preparation
demetilvermectins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88300426T
Other languages
English (en)
Inventor
Edmund William Hafner
Kelvin Scott Holdom
Shih-Jen Edward Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2053719T3 publication Critical patent/ES2053719T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DEMETILVERMECTINAS NO NATURALES UTILES COMO PARASITICIDAS Y SU PROCEDIMIENTO
ES88300426T 1987-01-23 1988-01-20 Dimetilvermectinas no naturales y procedimiento para su preparacion. Expired - Lifetime ES2053719T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US651287A 1987-01-23 1987-01-23

Publications (1)

Publication Number Publication Date
ES2053719T3 true ES2053719T3 (es) 1994-08-01

Family

ID=21721247

Family Applications (2)

Application Number Title Priority Date Filing Date
ES88300354T Expired - Lifetime ES2059498T3 (es) 1987-01-23 1988-01-18 Procedimiento para la produccion de avermectina b y cultivos para ello.
ES88300426T Expired - Lifetime ES2053719T3 (es) 1987-01-23 1988-01-20 Dimetilvermectinas no naturales y procedimiento para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES88300354T Expired - Lifetime ES2059498T3 (es) 1987-01-23 1988-01-18 Procedimiento para la produccion de avermectina b y cultivos para ello.

Country Status (30)

Country Link
EP (2) EP0276103B1 (es)
JP (2) JPH0681757B2 (es)
KR (2) KR900004419B1 (es)
CN (1) CN1056883C (es)
AR (1) AR241798A1 (es)
AT (2) ATE96174T1 (es)
AU (2) AU595673B2 (es)
BG (1) BG51051A3 (es)
BR (1) BR8800271A (es)
CZ (1) CZ279782B6 (es)
DD (2) DD290214A5 (es)
DE (2) DE3884973T2 (es)
DK (2) DK175720B1 (es)
EG (1) EG18797A (es)
ES (2) ES2059498T3 (es)
FI (2) FI90091C (es)
GR (1) GR3007586T3 (es)
HU (2) HU200487B (es)
IE (2) IE61066B1 (es)
IL (2) IL85118A (es)
IN (1) IN167980B (es)
MA (1) MA21160A1 (es)
MY (1) MY103514A (es)
NZ (2) NZ223272A (es)
PL (2) PL156763B1 (es)
PT (2) PT86583B (es)
RU (1) RU1806198C (es)
SK (1) SK40788A3 (es)
YU (1) YU47878B (es)
ZA (3) ZA88449B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
ES2054822T3 (es) * 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
GB8807280D0 (en) * 1988-03-26 1988-04-27 Pfizer Ltd Antiparasitic agents
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
GB8815967D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Antiparasitic agents
NZ231773A (en) * 1988-12-23 1992-09-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof
NZ231772A (en) * 1988-12-23 1992-11-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal compositions thereof
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US4897383A (en) * 1989-02-13 1990-01-30 Merck & Co., Inc. Avermectin derivatives
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5057499A (en) * 1989-06-02 1991-10-15 Merck & Co. Inc. Avermectin derivatives
US5023241A (en) * 1989-07-31 1991-06-11 Merck & Co., Inc. Avermectin derivatives
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
US5169839A (en) * 1990-05-11 1992-12-08 Merck & Co., Inc. Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5240915A (en) * 1991-10-15 1993-08-31 Merck & Co., Inc. Avermectin derivatives
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
CN1038330C (zh) * 1993-07-05 1998-05-13 塞泰克斯公司 阿弗麦菌素的生产与分离
PL181916B1 (en) * 1993-07-30 2001-10-31 Pfizer Method of obtaining natural avermectin
JP2761296B2 (ja) * 1993-10-05 1998-06-04 フアイザー・インコーポレイテツド ドラメクチンの製造方法および駆虫性中間体
FI942725A7 (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5701591A (en) * 1995-04-07 1997-12-23 Telecommunications Equipment Corporation Multi-function interactive communications system with circularly/elliptically polarized signal transmission and reception
EA003905B1 (ru) * 1998-02-13 2003-10-30 Пфайзер Продактс Инк. Ген streptomyces avermitilis, контролирующий соотношение авермектинов b2:b1
CA2380872C (en) * 1999-08-12 2007-11-27 Yan Chen Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
KR100415395B1 (ko) * 2000-08-02 2004-01-16 한국생명공학연구원 에버멕틴 ｂｃ-5-ｏ-메칠트랜스퍼라제의 유전자가 파괴된 스트렙토마이세스 에버미티리스 변이균주 및 그의 제조 방법
DK1476539T3 (da) 2002-02-12 2009-05-11 Pfizer Prod Inc Streptomyces avermitilis gen dirigerende forholdet af B2:B1 avermectiner
WO2023203038A1 (en) 2022-04-19 2023-10-26 Syngenta Crop Protection Ag Insect, acarina and nematode pest control

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
NZ188459A (en) * 1977-10-03 1982-09-07 Merck & Co Inc Derivatives of c-076 compounds and pesticidal compositions
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
CZ279782B6 (cs) 1995-06-14
IE61483B1 (en) 1994-11-02
JPS63291576A (ja) 1988-11-29
AU631298B2 (en) 1992-11-19
SK279351B6 (sk) 1998-10-07
FI880280A0 (fi) 1988-01-22
PL270239A1 (en) 1989-06-26
DK28988A (da) 1988-07-24
JPS63270684A (ja) 1988-11-08
DE3879975D1 (de) 1993-05-13
DK28988D0 (da) 1988-01-22
ZA88448B (en) 1989-08-30
PL270238A1 (en) 1989-06-26
ATE96174T1 (de) 1993-11-15
DE3884973D1 (de) 1993-11-25
FI880281A0 (fi) 1988-01-22
AU7111091A (en) 1991-08-08
EP0276131B1 (en) 1993-04-07
BR8800271A (pt) 1988-09-06
FI90088C (fi) 1993-12-27
EP0276103A2 (en) 1988-07-27
KR880009122A (ko) 1988-09-14
FI90091C (fi) 1993-12-27
NZ223272A (en) 1989-12-21
MY103514A (en) 1993-07-31
IN167980B (es) 1991-01-19
IL85165A (en) 1992-07-15
PT86584B (pt) 1991-12-31
YU47878B (sh) 1996-05-20
ES2059498T3 (es) 1994-11-16
ZA88447B (en) 1989-08-30
DD267512A5 (de) 1989-05-03
ZA88449B (en) 1989-08-30
FI880281L (fi) 1988-07-24
AU603416B2 (en) 1990-11-15
PT86583A (en) 1988-02-01
HUT47978A (en) 1989-04-28
HU201973B (en) 1991-01-28
FI880280A7 (fi) 1988-07-24
IL85118A (en) 1993-01-31
KR900004419B1 (ko) 1990-06-25
PL156763B1 (pl) 1992-04-30
SK40788A3 (en) 1998-10-07
YU11988A (en) 1989-08-31
MA21160A1 (fr) 1988-10-01
CN1056883C (zh) 2000-09-27
AU1074288A (en) 1988-07-28
KR880009027A (ko) 1988-09-13
EP0276103A3 (en) 1989-11-08
AU1069688A (en) 1988-07-28
RU1806198C (ru) 1993-03-30
ATE87927T1 (de) 1993-04-15
DK29088D0 (da) 1988-01-22
DD290214A5 (de) 1991-05-23
NZ223271A (en) 1991-12-23
DK29088A (da) 1988-07-24
EP0276131A2 (en) 1988-07-27
DE3884973T2 (de) 1994-02-17
IL85118A0 (en) 1988-06-30
FI90091B (fi) 1993-09-15
GR3007586T3 (es) 1993-08-31
DE3879975T2 (de) 1993-07-15
AR241798A1 (es) 1992-12-30
FI90088B (fi) 1993-09-15
EP0276131A3 (en) 1989-10-25
IE880161L (en) 1988-07-23
IL85165A0 (en) 1988-07-31
EP0276103B1 (en) 1993-10-20
AU595673B2 (en) 1990-04-05
PT86584A (en) 1988-02-01
CN88100649A (zh) 1988-10-26
IE61066B1 (en) 1994-09-21
HU200487B (en) 1990-06-28
CZ40788A3 (en) 1994-12-15
KR910002225B1 (ko) 1991-04-08
PT86583B (pt) 1991-12-31
PL156764B1 (pl) 1992-04-30
DK175720B1 (da) 2005-02-07
BG51051A3 (bg) 1993-01-15
JPH0817693B2 (ja) 1996-02-28
HUT47644A (en) 1989-03-28
JPH0681757B2 (ja) 1994-10-19
IE880160L (en) 1988-07-23
EG18797A (en) 1994-06-30

Similar Documents

Publication Publication Date Title
ES2053719T3 (es) Dimetilvermectinas no naturales y procedimiento para su preparacion.
MX10621A (es) Compuestos de piperazinil heterociclicos y procedimiento para su preparacion.
DE3886433D1 (de) Desodoriervorrichtung.
NL192505B (nl) Schaar.
MX9845A (es) Propanaminas 3-ariloxi-3-substituidas y procedimiento para su preparacion.
SE8501709D0 (sv) Improvements in or relating to intrleukin therapy
FI883797L (fi) Loeddersaenkande tillsatser i laogloeddrande reningsmedel.
NO168007C (no) Isolator for hoeyspenning.
ES2022871B3 (es) Procedimiento para preparar cetiminas incoloras.
ES2039198T3 (es) Procedimiento para preparar 5-amino y 5-hidroxi-6,8-difluorquinolonas como agentes antibacteriales.
FI800795A7 (fi) Uudet peptidit ja menetelmiä niiden valmistamiseksi.
DE3881579D1 (de) Ionenquelle.
ES2148142T3 (es) Compuestos de 2-aril-5-(trifluorometil)-2-pirrolina y procedimiento para la fabricacion de insecticidas de 2-aril-1-(alcoximetil)-4-halo-5-(trifluorometil)pirrol.
DE3887551D1 (de) Gebundene Antioxydationsvormischung.
IT8820388A0 (it) Composizione oftalmologica.
ES8507565A1 (es) Procedimiento para preparar n-fosfonometilglicina
ES496903A0 (es) Procedimiento de modificacion artificial de las precipitaciones atmosfericos,.
ES2042726T3 (es) Beta-alquilmelatoninas.
IT7826949A0 (it) Procedimento di preparazione di pezzi in ceramica mediante elettroforesi.
IT8083454A0 (it) Harzburgite e procedimento per lapreparazione della stessa.
ES8704469A1 (es) Procedimiento para preparar naftoxacinas
DK179188D0 (da) Fremgangsmaade til dyrkning af mikroorganismer
DK160436C (da) Immobiliseret vanduoploeselig lactase
IT8023314A0 (it) 4-tiazolidoni 2-sostituiti utili come farmaci e procedimento per laloro preparazione.
ES541295A0 (es) Procedimiento para preparar isocromanos y oxepinas, susti- tuidos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 276131

Country of ref document: ES