ES2053837T3 - Compuestos de acido 3-pirrolidiniltio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilico. - Google Patents

Compuestos de acido 3-pirrolidiniltio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilico.

Info

Publication number
ES2053837T3
ES2053837T3 ES89104619T ES89104619T ES2053837T3 ES 2053837 T3 ES2053837 T3 ES 2053837T3 ES 89104619 T ES89104619 T ES 89104619T ES 89104619 T ES89104619 T ES 89104619T ES 2053837 T3 ES2053837 T3 ES 2053837T3
Authority
ES
Spain
Prior art keywords
pirrolidinyltio
azabiciclo
carboxilico
eno
hept
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89104619T
Other languages
English (en)
Inventor
Masayoshi Murata
Hideo Tsutsumi
Keiji Matsuda
Kohji Hattori
Takashi Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888806428A external-priority patent/GB8806428D0/en
Priority claimed from GB888812159A external-priority patent/GB8812159D0/en
Priority claimed from GB888821760A external-priority patent/GB8821760D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2053837T3 publication Critical patent/ES2053837T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN COMPUESTO DE LA FORMULA (I) EN LA QUE R EXP1 ES CARBOXI O CARBOXI PROTEGIDO, R (AL CUADRADO) ES HIDROXI (INFERIOR) ALQUILO O HIDROXI (INFERIOR) ALQUILO PROTEGIDO, R EXP3 ES HIDROGENO O ALQUILO INFERIOR, R EXP4 ES UN GRUPO HETEROCICLICO ALIFATICO QUE PUEDE SER SUSTITUIDO POR SUSTITUYENTE (S) CONVENIENTE, R EXP5 ES HIDROGENO, GRUPO ALQUILO INFERIOR O IMINO PROTECTOR Y A ES ALQUILENO INFERIOR, O SALES DE ESTO FARMACEUTICAMENTE ACEPTABLES, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN COMO INGREDIENTE ACTIVO EN MEZCLA CON UN SOPORTE O EXCIPIENTE ACEPTABLE FARMACEUTICAMENTE.
ES89104619T 1988-03-18 1989-03-15 Compuestos de acido 3-pirrolidiniltio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilico. Expired - Lifetime ES2053837T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888806428A GB8806428D0 (en) 1988-03-18 1988-03-18 3-pyrrolidinylthio-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds
GB888812159A GB8812159D0 (en) 1988-05-23 1988-05-23 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid compounds
GB888821760A GB8821760D0 (en) 1988-09-16 1988-09-16 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid compounds

Publications (1)

Publication Number Publication Date
ES2053837T3 true ES2053837T3 (es) 1994-08-01

Family

ID=27263828

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89104619T Expired - Lifetime ES2053837T3 (es) 1988-03-18 1989-03-15 Compuestos de acido 3-pirrolidiniltio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilico.

Country Status (7)

Country Link
US (1) US4925838A (es)
EP (1) EP0333175B1 (es)
JP (1) JP2754679B2 (es)
KR (1) KR890014541A (es)
AT (1) ATE107306T1 (es)
DE (1) DE68916071T2 (es)
ES (1) ES2053837T3 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202437A (en) * 1988-03-18 1993-04-13 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid compounds
AU631671B2 (en) * 1989-08-04 1992-12-03 Banyu Pharmaceutical Co., Ltd. 2-(2-vinylpyrrolidinylthio)carbapenem derivatives
GB8923844D0 (en) * 1989-10-23 1989-12-13 Fujisawa Pharmaceutical Co Carbapenem compounds
CA2033390A1 (en) * 1989-12-29 1991-06-30 Susumu Nakagawa 2-(2-cyclopropylpyrrolidin-4-ylthio) carbapenem derivatives
US5227376A (en) * 1990-02-14 1993-07-13 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds and their production
IE910606A1 (en) * 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
JPH0764846B2 (ja) * 1990-03-27 1995-07-12 萬有製薬株式会社 ２−（置換ピロリジニルチオ）カルバペネム誘導体
TW198034B (es) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
US5373002A (en) * 1990-03-27 1994-12-13 Banyu Pharmaceutical Co., Ltd. 2-(substituted pyrrolidinylthio) carbapenem derivatives
US5374720A (en) * 1990-03-27 1994-12-20 Banyu Pharmaceutical Co., Ltd. 2-(substituted pyrrolidinylthio)carbapenem derivatives
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
WO1993006102A1 (fr) * 1991-09-27 1993-04-01 Banyu Pharmaceutical Co., Ltd. Derive de 2-(pyrrolidinylthio substitue) carbapenem
CA2117899A1 (en) * 1992-04-13 1993-10-28 Masayoshi Murata Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
CA2099811A1 (en) * 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
GB9320816D0 (en) * 1993-10-08 1993-12-01 Fujisawa Pharmaceutical Co Novel compounds
US5707987A (en) * 1994-02-25 1998-01-13 Banyu Pharmaceutical Co., Ltd. Carbapenem derivatives
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
KR100345468B1 (ko) * 2000-07-10 2002-07-26 한국과학기술연구원 신규 1-베타메틸카바페넴 유도체 및 그의 제조방법
MXPA03000368A (es) 2000-07-19 2004-09-13 Hoffmann La Roche Derivados de pirrolidina como inhibidores de metalproteasa.
CA2569116A1 (en) 2004-06-10 2005-12-29 Fob Synthesis, Inc. Gram-positive carbapenem antibacterials and processes for their preparation
CA2584507C (en) 2004-10-20 2016-04-26 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
EP2314295B1 (en) 2005-07-29 2015-01-28 Resverlogix, Inc Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
CA2676984C (en) 2007-02-01 2015-03-17 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
EP2177522B1 (en) * 2007-06-28 2013-09-04 XuanZhu Pharma Co., Ltd. Novel carbapenem derivatives
CA2711103C (en) 2008-06-26 2016-08-09 Resverlogix Corp. Methods of preparing quinazolinone derivatives
AU2010204106B2 (en) 2009-01-08 2014-05-08 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
WO2010106436A2 (en) 2009-03-18 2010-09-23 Resverlogix Corp. Novel anti-inflammatory agents
AU2010239266B2 (en) 2009-04-22 2015-01-22 Resverlogix Corp. Novel anti-inflammatory agents
DK2590978T3 (en) 2010-06-18 2018-01-02 Fob Synthesis Inc CARBAPENEM ANTIBACTERIAL AGENTS WITH GRAM-NEGATIVE ACTIVITY
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
WO2016147053A1 (en) 2015-03-13 2016-09-22 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
KR900006449B1 (ko) * 1982-08-24 1990-08-31 상꾜 가부시끼가이샤 아제티디논 화합물의 제조방법
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
DE3579888D1 (de) * 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
EP0243686B1 (en) * 1986-03-27 1992-07-15 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
EP0272455B1 (en) * 1986-11-24 1993-02-10 Fujisawa Pharmaceutical Co., Ltd. 3-Pyrrolidinylthio-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid compounds

Also Published As

Publication number Publication date
DE68916071T2 (de) 1994-10-20
JP2754679B2 (ja) 1998-05-20
JPH021491A (ja) 1990-01-05
KR890014541A (ko) 1989-10-24
DE68916071D1 (de) 1994-07-21
EP0333175A1 (en) 1989-09-20
EP0333175B1 (en) 1994-06-15
ATE107306T1 (de) 1994-07-15
US4925838A (en) 1990-05-15

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