ES2053983T3 - Carboxamidas hetera-alifaticas. - Google Patents
Carboxamidas hetera-alifaticas.Info
- Publication number
- ES2053983T3 ES2053983T3 ES89303623T ES89303623T ES2053983T3 ES 2053983 T3 ES2053983 T3 ES 2053983T3 ES 89303623 T ES89303623 T ES 89303623T ES 89303623 T ES89303623 T ES 89303623T ES 2053983 T3 ES2053983 T3 ES 2053983T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- formula
- hetera
- manufacture
- carboxamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003857 carboxamides Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 206010014824 Endotoxic shock Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 206010044541 Traumatic shock Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 231100000284 endotoxic Toxicity 0.000 abstract 1
- 230000002346 endotoxic effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ESTA INVENCION PROPORCIONA UNA SERIE DE NUEVAS CARBOXAMIDAS HETEROALIFATICAS DE FORMULA I, EN LA QUE EL GRUPO > Z - Y - X < SE SELECCIONA DE > C = CH - N <, > N - CH = C <, > C = N - N < Y > N N = C < Y LOS OTROS RADICALES TIENEN LOS SIGNIFICADOS DEFINIDOS EN LA SIGUIENTE ESPECIFICACION. LOS COMPUESTOS DE FORMULA (I) SON ANTAGONISTAS DE LEUCOTRIENO. LA INVENCION PROPORCIONA TAMBIEN SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS DE FORMULA (I); COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS CITADOS COMPUESTOS O SUS SALES, PARA EMPLEO EN EL TRATAMIENTO, POR EJEMPLO, DE ENFERMEDADES ALERGICAS O INFLAMATORIAS O CONDICIONES DE SHOCK ENDOTOXICO O TRAUMATICO; Y PROCESOS PARA LA FABRICACION DE LOS COMPUESTOS DE FORMULA (I) ASI COMO DE COMPUESTOS INTERMEDIOS PARA EMPLEO EN TAL FABRICACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18133488A | 1988-04-14 | 1988-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053983T3 true ES2053983T3 (es) | 1994-08-01 |
Family
ID=22663845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89303623T Expired - Lifetime ES2053983T3 (es) | 1988-04-14 | 1989-04-12 | Carboxamidas hetera-alifaticas. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0337766B1 (es) |
| JP (1) | JP2740250B2 (es) |
| KR (1) | KR890016016A (es) |
| CN (1) | CN1037895A (es) |
| AT (1) | ATE86612T1 (es) |
| AU (1) | AU622649B2 (es) |
| CA (1) | CA1334197C (es) |
| DD (1) | DD286581A5 (es) |
| DE (1) | DE68905216T2 (es) |
| DK (1) | DK176089A (es) |
| ES (1) | ES2053983T3 (es) |
| FI (1) | FI891764A7 (es) |
| GB (1) | GB8906032D0 (es) |
| GR (1) | GR3007302T3 (es) |
| HU (1) | HUT54995A (es) |
| IE (1) | IE63209B1 (es) |
| IL (1) | IL89925A0 (es) |
| MW (1) | MW2189A1 (es) |
| NO (1) | NO891501L (es) |
| NZ (1) | NZ228722A (es) |
| PT (1) | PT90269B (es) |
| ZA (1) | ZA892637B (es) |
| ZM (1) | ZM1689A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927981D0 (en) * | 1989-12-11 | 1990-02-14 | Ici Plc | Carbamoyl derivative |
| GB9119001D0 (en) * | 1991-09-05 | 1991-10-23 | Ici Plc | Pharmaceutical agents |
| ES2072125T3 (es) * | 1991-10-25 | 1995-07-01 | Ciba Geigy Ag | Procedimiento para la obtencion de indoles substituidos. |
| EP0539329A1 (de) * | 1991-10-25 | 1993-04-28 | Ciba-Geigy Ag | Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten |
| EP0751126A4 (en) * | 1995-01-06 | 1998-05-13 | Toray Industries | BENZOCONDENSE HETEROCYCLIC DERIVATIVE AND ITS USE |
| PL343007A1 (en) * | 1998-02-25 | 2001-07-30 | Genetics Inst | Inhibitors of phospholipase enzymes |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| TW201309670A (zh) | 2011-01-25 | 2013-03-01 | Kissei Pharmaceutical | 吲哚衍生物或其藥理學上容許之鹽 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8524157D0 (en) * | 1984-10-19 | 1985-11-06 | Ici America Inc | Heterocyclic amides |
-
1989
- 1989-03-16 GB GB898906032A patent/GB8906032D0/en active Pending
- 1989-03-29 AU AU31770/89A patent/AU622649B2/en not_active Withdrawn - After Issue
- 1989-04-04 ZM ZM16/89A patent/ZM1689A1/xx unknown
- 1989-04-11 ZA ZA892637A patent/ZA892637B/xx unknown
- 1989-04-12 CA CA000596518A patent/CA1334197C/en not_active Expired - Fee Related
- 1989-04-12 DE DE8989303623T patent/DE68905216T2/de not_active Expired - Fee Related
- 1989-04-12 NO NO89891501A patent/NO891501L/no unknown
- 1989-04-12 HU HU891740A patent/HUT54995A/hu unknown
- 1989-04-12 ES ES89303623T patent/ES2053983T3/es not_active Expired - Lifetime
- 1989-04-12 NZ NZ228722A patent/NZ228722A/xx unknown
- 1989-04-12 DK DK176089A patent/DK176089A/da not_active Application Discontinuation
- 1989-04-12 IL IL89925A patent/IL89925A0/xx unknown
- 1989-04-12 AT AT89303623T patent/ATE86612T1/de not_active IP Right Cessation
- 1989-04-12 DD DD89327554A patent/DD286581A5/de not_active IP Right Cessation
- 1989-04-12 EP EP89303623A patent/EP0337766B1/en not_active Expired - Lifetime
- 1989-04-13 PT PT90269A patent/PT90269B/pt active IP Right Grant
- 1989-04-13 CN CN89102211A patent/CN1037895A/zh active Pending
- 1989-04-13 FI FI891764A patent/FI891764A7/fi not_active Application Discontinuation
- 1989-04-13 IE IE118889A patent/IE63209B1/en not_active IP Right Cessation
- 1989-04-13 JP JP1091993A patent/JP2740250B2/ja not_active Expired - Fee Related
- 1989-04-14 KR KR1019890005081A patent/KR890016016A/ko not_active Withdrawn
- 1989-04-14 MW MW21/89A patent/MW2189A1/xx unknown
-
1993
- 1993-03-11 GR GR920402606T patent/GR3007302T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI891764A0 (fi) | 1989-04-13 |
| DK176089A (da) | 1989-10-15 |
| AU622649B2 (en) | 1992-04-16 |
| HUT54995A (en) | 1991-04-29 |
| NO891501D0 (no) | 1989-04-12 |
| ZM1689A1 (en) | 1990-01-26 |
| DK176089D0 (da) | 1989-04-12 |
| IL89925A0 (en) | 1989-12-15 |
| CA1334197C (en) | 1995-01-31 |
| KR890016016A (ko) | 1989-11-28 |
| GB8906032D0 (en) | 1989-04-26 |
| CN1037895A (zh) | 1989-12-13 |
| JPH01311063A (ja) | 1989-12-15 |
| EP0337766A1 (en) | 1989-10-18 |
| MW2189A1 (en) | 1989-12-13 |
| IE63209B1 (en) | 1995-04-05 |
| ATE86612T1 (de) | 1993-03-15 |
| AU3177089A (en) | 1989-10-19 |
| GR3007302T3 (es) | 1993-07-30 |
| DE68905216D1 (de) | 1993-04-15 |
| PT90269A (pt) | 1989-11-10 |
| DD286581A5 (de) | 1991-01-31 |
| NO891501L (no) | 1989-10-16 |
| DE68905216T2 (de) | 1993-06-17 |
| FI891764A7 (fi) | 1989-10-15 |
| PT90269B (pt) | 1994-07-29 |
| NZ228722A (en) | 1991-08-27 |
| JP2740250B2 (ja) | 1998-04-15 |
| ZA892637B (en) | 1989-12-27 |
| EP0337766B1 (en) | 1993-03-10 |
| IE891188L (en) | 1989-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR032136A1 (es) | Compuestos espiroheterociclicos utiles como inhibidores reversibles de cisteina-proteasas | |
| ES2056190T3 (es) | Derivados de 4(4-fenil-1-piperazinil)fenoles, inhibidores de 5-lipoxigenasa. | |
| CO5180642A1 (es) | Compuestos sustituidos de piperidina, procesos para su prepa racion, composiciones farmaceuticas que los contienen y su utilizacion | |
| PA8575401A1 (es) | Derivados de heteroarilamida benzocondensada de tienopiridinas utiles como agentes terapeuticos, composiciones farmaceuticas que incluyen a los mismos y metrodos para su uso | |
| ES2168487T3 (es) | Derivados de n-heteroaril-piridinasulfonamida y su uso como antagonistas de la endotelina. | |
| ES2163407T3 (es) | Derivados piperidinilos tiaciclicos. | |
| ES2155067T3 (es) | Fenilimidazolidinas sustituidas, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. | |
| AR029383A1 (es) | Moleculas pequenas, los intermediarios para su sintesis, las composiciones farmaceuticas que las contienen y su uso para preparar un medicamento destinado al tratamiento o la profilaxis de enfermedades inflamatorias o mediadas por celulas inmunes | |
| AR036032A1 (es) | Compuesto derivado de quinolina, composicion que lo comprende; uso del mismo en la fabricacion de medicamentos, proceso para prepararlo, y metodo para detectar y seleccionar un agente que module la actividad del mif | |
| AR057873A2 (es) | Compuestos derivados de piperizina utiles como antagonistas ccr5, composiciones farmaceuticas que los comprenden, y el uso de los mismos para la preparacion de medicamentos | |
| CL2004000590A1 (es) | Compuestos derivados de 1,3,4-oxadiazol-3-ona, 1,3,4-tiadiazol-2-ona y de 1,2,4-triazol-3-ona; composicion farmaceutica que los contiene; procedimiento de preparacion y su uso en la preparacion de un medicamento en los que esta relacionado el virus v | |
| GT199700095A (es) | Derivados 6,5-heterobiciclicos sustituidos. | |
| ATE334973T1 (de) | Chinazolinverbindungen | |
| ES2038172T3 (es) | Procedimiento para preparar carboxamidas heterociclicas. | |
| AR029215A1 (es) | Derivados de benzazol y tautomeros de los mismos utiles en el tratamiento de desordenes en los sistemas de autoinmunidad y neuronales, uso de dichos derivados en la preparacion de composiciones farmaceuticas aplicables en el tratamiento de dichos desordenes, metodo prar inhibir la expresion y/o acti | |
| UY27259A1 (es) | Derivados de dihidro-benzo b 1, 4- diazepin-2ona como antagonistas i de mglur2 | |
| PA8568101A1 (es) | Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso | |
| PT90269A (pt) | Processo para a preparacao de carboxamidas hetero-alifaticas e de composicoes farmaceuticas que as contem | |
| ES2045420T3 (es) | Amidas ciclicas. | |
| AR007108A1 (es) | Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. | |
| MY103259A (en) | Aliphatic carboxamides | |
| MX9205123A (es) | Derivados de 5-hidroxi-2-pirimidinilmetileno utiles como agentes anti-inflamatorios. | |
| AR017146A1 (es) | Compuestos de 1-(fenil-sustituido)-5-(4-metilsulfonilfenil)pirazol; procedimiento para prepararlos, las composiciones farmaceuticas que los contienen,los agentes inhibidores de la cox-ii que los contienen y el uso de dichos compuestos para la fabricacion de medicamentos. | |
| UY28535A1 (es) | Derivados de bencimidazol, composiciones que los contienen, preparacion y usos de los mismos. | |
| UY26079A1 (es) | Nuevos derivados de morfolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 337766 Country of ref document: ES |