ES2054037T3 - SYNTHESIS PROCEDURE OF AZIDO-3'-DESOXI-3'-THYMIDINE AND ANALOGS. - Google Patents

SYNTHESIS PROCEDURE OF AZIDO-3'-DESOXI-3'-THYMIDINE AND ANALOGS.

Info

Publication number
ES2054037T3
ES2054037T3 ES89400155T ES89400155T ES2054037T3 ES 2054037 T3 ES2054037 T3 ES 2054037T3 ES 89400155 T ES89400155 T ES 89400155T ES 89400155 T ES89400155 T ES 89400155T ES 2054037 T3 ES2054037 T3 ES 2054037T3
Authority
ES
Spain
Prior art keywords
desoxi
azido
thymidine
analogs
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89400155T
Other languages
Spanish (es)
Inventor
Stanislas Czernecki
Jean-Marc Valery
Guy Ville
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Pierre et Marie Curie
Original Assignee
Universite Pierre et Marie Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8800553A external-priority patent/FR2626001B1/en
Application filed by Universite Pierre et Marie Curie filed Critical Universite Pierre et Marie Curie
Application granted granted Critical
Publication of ES2054037T3 publication Critical patent/ES2054037T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA(I), EN LA QUE R1 ES H, UN RADICAL ALQUILO, UN RADICAL ALCOXI, HIDROXIALQUILO O HALOGENO, Y R3 ES N3, UN RADICAL CN, CARACTEIZADO EN QUE SE HACE REACCIONAR UN COMPUESTO DE FORMULA(III), EN LA QUE DESPUES DE UNA EVENTUAL SEPARACION, SE ABRE EN PRESENCIA DE UN NITROGENURO O DE UN CIANURO EN UN DISOLVENTE COMPATIBLE CON LAS CONDICIONES DE REACCION, EL COMPUESTO DE FORMULA(I) ES AISLADO A CONTINUACION DEL MEDIO REACCIONAL, DESPUES DESPROTECCION DE LA POSICION 5''.THE INVENTION REFERS TO A PROCEDURE FOR PREPARING A COMPOUND OF FORMULA (I), IN WHICH R1 IS H, A RADICAL ALKYL, A RADICAL ALCOXI, HYDROXYALKYL OR HALOGEN, AND R3 IS N3, A RADICAL CN, CHARACTERIZED IN WHICH REACTS A COMPOUND OF FORMULA (III), IN WHICH, AFTER AN EVENTUAL SEPARATION, IT OPENS IN THE PRESENCE OF A NITROGENIDE OR A CYANIDE IN A SOLVENT COMPATIBLE WITH THE CONDITIONS OF REACTION, THE COMPOUND OF FORMULA (I) IS ISOLATED TO CONTINUATION OF THE REACTIONAL ENVIRONMENT, AFTER DEPOSIT OF THE 5 '' POSITION.

ES89400155T 1988-01-19 1989-01-19 SYNTHESIS PROCEDURE OF AZIDO-3'-DESOXI-3'-THYMIDINE AND ANALOGS. Expired - Lifetime ES2054037T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8800553A FR2626001B1 (en) 1988-01-19 1988-01-19 PROCESS FOR THE SYNTHESIS OF AZIDO-3ŸI1Ÿ.-DESOXY-3ŸI1Ÿ.-THYMIDINE AND THE LIKE
FR888816248A FR2640267B2 (en) 1988-01-19 1988-12-09 PROCESS FOR THE SYNTHESIS OF AZIDO-3 (PRIME) -DESOXY-3 (PRIME) -THYMIDINE AND THE LIKE

Publications (1)

Publication Number Publication Date
ES2054037T3 true ES2054037T3 (en) 1994-08-01

Family

ID=26226456

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89400155T Expired - Lifetime ES2054037T3 (en) 1988-01-19 1989-01-19 SYNTHESIS PROCEDURE OF AZIDO-3'-DESOXI-3'-THYMIDINE AND ANALOGS.

Country Status (9)

Country Link
US (1) US5101023A (en)
EP (1) EP0325537B1 (en)
JP (1) JP2619726B2 (en)
KR (1) KR930011283B1 (en)
CA (1) CA1325423C (en)
DE (1) DE68905831T2 (en)
ES (1) ES2054037T3 (en)
FR (1) FR2640267B2 (en)
WO (1) WO1989006655A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726585D0 (en) * 1987-11-13 1987-12-16 London Kings College Chemical process
FR2653771B1 (en) * 1989-10-27 1994-09-23 Univ Paris Curie PROCESS FOR THE PREPARATION OF AZT (AZIDO-3'-DESOXY-3'-THYMIDINE) AND RELATED COMPOUNDS.
IT1246983B (en) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-DESOXYURIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
JPH04368382A (en) * 1991-06-14 1992-12-21 Japan Tobacco Inc Production of 2',3'-dideoxy-beta-nucleoside
RU2085557C1 (en) * 1991-09-30 1997-07-27 Санкио Компани Лимитед Pyrimidine nucleoside derivatives or their pharmaceutically acceptable salts and method of their synthesis
FI90552C (en) * 1991-10-09 1994-02-25 Leiras Oy Method for preparing nucleoside derivatives
JP3677790B2 (en) * 1993-08-04 2005-08-03 味の素株式会社 Nucleoside derivatives and process for producing the same
US5466787A (en) * 1993-11-15 1995-11-14 Bristol-Myers Squibb Company Process for preparing AZT
AU6630996A (en) * 1995-08-04 1997-03-05 Kobayashi Perfumery Co., Ltd. Process for producing azido nucleoside derivatives
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE73219B1 (en) * 1985-03-16 1997-05-07 Wellcome Found Therapeutic nucleosides
US4681933A (en) * 1986-05-01 1987-07-21 University Of Georgia Research Foundation, Inc. 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents

Also Published As

Publication number Publication date
JP2619726B2 (en) 1997-06-11
WO1989006655A1 (en) 1989-07-27
KR900700477A (en) 1990-08-13
KR930011283B1 (en) 1993-11-29
DE68905831T2 (en) 1993-07-22
CA1325423C (en) 1993-12-21
DE68905831D1 (en) 1993-05-13
FR2640267A2 (en) 1990-06-15
EP0325537B1 (en) 1993-04-07
EP0325537A1 (en) 1989-07-26
JPH02503002A (en) 1990-09-20
US5101023A (en) 1992-03-31
FR2640267B2 (en) 1992-02-14

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