ES2054604T1 - Un procedimiento para la preparacion de intermediarios de alquenilsililazetidinona para carbapenems. - Google Patents

Un procedimiento para la preparacion de intermediarios de alquenilsililazetidinona para carbapenems.

Info

Publication number
ES2054604T1
ES2054604T1 ES88115397T ES88115397T ES2054604T1 ES 2054604 T1 ES2054604 T1 ES 2054604T1 ES 88115397 T ES88115397 T ES 88115397T ES 88115397 T ES88115397 T ES 88115397T ES 2054604 T1 ES2054604 T1 ES 2054604T1
Authority
ES
Spain
Prior art keywords
enil
azetidinone
alk
alquenilsililazetidinona
carbapenems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES88115397T
Other languages
English (en)
Other versions
ES2054604T3 (es
Inventor
Shoichiro Izutsuya-Cho Uyeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES2054604T1 publication Critical patent/ES2054604T1/es
Application granted granted Critical
Publication of ES2054604T3 publication Critical patent/ES2054604T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN INTERMEDIARIO PARA SINTETIZAR CARBAPENEMAS ES PRODUCIDO A TRAVES DE 1) UNA REACCION DE 4 - (SALIDA GRUPO SUSBTITUIDO) - 2 - AZETIDINONE (I) CON (ALK - 2 - ENIL) HALOSILANE (II) PARA PERMITIR 4 - (SALIDA DEL GRUPO SUSTITUIDO) - 1 - (ALK - 2 - ENIL) SILIL - 2 - AZETIDINONE (III) Y ENTONCES 2) UNA REACCION DEL PRODUCTO 4 - (SALIDA DEL GRUPO SUBSTITUIDO) - 1 - (ALK - 2 ENIL) SILIR - 2 - AZETIDINONE (III) CON ACIDO PARA DAR EL CORRESPONDIENTE 4 (ALK - 2 - ENIL) - 2 AZETIDINONE (IV) . (LOS SIMBOLOS SON DEFINIDOS EN LA ESPECIFICACION).
ES88115397T 1987-09-22 1988-09-20 Intermedios alquenilsililazetidinona para carbapenemes. Expired - Lifetime ES2054604T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23806687 1987-09-22

Publications (2)

Publication Number Publication Date
ES2054604T1 true ES2054604T1 (es) 1994-08-16
ES2054604T3 ES2054604T3 (es) 1995-12-01

Family

ID=17024647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88115397T Expired - Lifetime ES2054604T3 (es) 1987-09-22 1988-09-20 Intermedios alquenilsililazetidinona para carbapenemes.

Country Status (9)

Country Link
US (1) US4960880A (es)
EP (1) EP0308867B1 (es)
KR (1) KR960006800B1 (es)
AT (1) ATE125543T1 (es)
AU (2) AU600169B2 (es)
CA (1) CA1327808C (es)
DE (1) DE3854215T2 (es)
ES (1) ES2054604T3 (es)
GR (2) GR910300002T1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2653429B1 (fr) * 1989-10-25 1991-12-20 Adir Nouveaux derives de l'azetidin-2-one, 1,3,4-trisubstitues, intermediaires utiles pour la synthese des beta-lactames, et leur procede de synthese asymetrique.
GB9015485D0 (en) * 1990-07-13 1990-08-29 Glaxo Spa Heterocyclic derivatives
SK282164B6 (sk) * 1992-09-18 2001-11-06 Merck & Co., Inc. Spôsob výroby beta-metylkarbapenémových medziproduktov, medziprodukty na vykonávanie tohto postupu a spôsob výroby medziproduktov
US7285674B2 (en) * 2004-05-06 2007-10-23 Interuniversitair Microelektronica Centrum (Imec) Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6253994A (ja) * 1985-05-09 1987-03-09 Yamanouchi Pharmaceut Co Ltd １−置換シリル−４−オキソ−２−アゼチジンカルボン酸低級アルキルエステル
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates

Also Published As

Publication number Publication date
DE3854215D1 (de) 1995-08-31
EP0308867A3 (en) 1990-08-16
ATE125543T1 (de) 1995-08-15
KR960006800B1 (ko) 1996-05-23
EP0308867B1 (en) 1995-07-26
AU621749B2 (en) 1992-03-19
GR3017323T3 (en) 1995-12-31
AU5509390A (en) 1990-10-04
AU2246688A (en) 1989-03-23
KR890005049A (ko) 1989-05-11
GR910300002T1 (en) 1991-11-15
DE3854215T2 (de) 1995-12-21
AU600169B2 (en) 1990-08-02
US4960880A (en) 1990-10-02
EP0308867A2 (en) 1989-03-29
ES2054604T3 (es) 1995-12-01
CA1327808C (en) 1994-03-15

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