ES2054657T3 - Nuevos oligosacaridos y su metodo de preparacion. - Google Patents

Nuevos oligosacaridos y su metodo de preparacion.

Info

Publication number
ES2054657T3
ES2054657T3 ES87202625T ES87202625T ES2054657T3 ES 2054657 T3 ES2054657 T3 ES 2054657T3 ES 87202625 T ES87202625 T ES 87202625T ES 87202625 T ES87202625 T ES 87202625T ES 2054657 T3 ES2054657 T3 ES 2054657T3
Authority
ES
Spain
Prior art keywords
preparation
new oligosaccharides
ribosa
ribitol
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87202625T
Other languages
English (en)
Inventor
Eduard Coen Beuvery
Adolf Evenberg
Jan Theunis Poolman
Boom Jacobus Hubertus Van
Peter Hoogerhout
Boeckel Constant Adriaan A Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of Netherlands
Original Assignee
Government of Netherlands
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of Netherlands filed Critical Government of Netherlands
Application granted granted Critical
Publication of ES2054657T3 publication Critical patent/ES2054657T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS OLIGOSACARIDOS QUE CONTIENEN LA ESTRUCTURA (D-RIBOSA-D-RIBITOL-FOSFATO)M, (D-RIBITOL-FOSFATO-D -RIBOSA)M O (FOSFATO-D-RIBOSA-D-RIBITOL)M, EN LA QUE M PUEDE VALER DESDE 2 HASTA 20, A INMUNOGENOS QUE CONTIENEN DICHOS OLIGOSACARIDOS, A VACUNAS QUE CONTIENEN ESTOS INMUNOGENOS Y A METODOS PARA SU PREPARACION. LA VACUNA ES MUY ADECUADA PARA EL TRATAMIENTO DE INFECCIONES CAUSADAS POR HAEMOPHILUS INFLUENZAE DE TIPO B.
ES87202625T 1986-12-31 1987-12-28 Nuevos oligosacaridos y su metodo de preparacion. Expired - Lifetime ES2054657T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8603325 1986-12-31

Publications (1)

Publication Number Publication Date
ES2054657T3 true ES2054657T3 (es) 1994-08-16

Family

ID=19849078

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87202625T Expired - Lifetime ES2054657T3 (es) 1986-12-31 1987-12-28 Nuevos oligosacaridos y su metodo de preparacion.

Country Status (15)

Country Link
US (1) US5034519A (es)
EP (1) EP0276516B1 (es)
JP (1) JPS63190896A (es)
KR (1) KR880007557A (es)
AT (1) ATE87003T1 (es)
AU (1) AU603405B2 (es)
CA (1) CA1335405C (es)
DE (1) DE3784907T2 (es)
DK (1) DK694687A (es)
ES (1) ES2054657T3 (es)
FI (1) FI89172C (es)
IE (1) IE59734B1 (es)
NO (1) NO169775C (es)
NZ (1) NZ223009A (es)
PT (1) PT86484B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0320942A3 (en) * 1987-12-18 1989-10-04 American Cyanamid Company Novel polysaccharides novel macromolecular conjugates of the polysaccharides
DE68915046T2 (de) * 1988-04-19 1994-12-08 American Cyanamid Co Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
EP0378929A3 (en) * 1988-12-23 1990-08-01 Connaught Laboratories Limited Membrane proteins and peptides of haemophilus influenzae type b
GB8924473D0 (en) * 1989-10-31 1989-12-20 Connaught Lab Outer membrane protein p1 and peptides of haemophilus influenzae b
NZ239643A (en) * 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
US5153312A (en) * 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
DE69130955T2 (de) * 1990-12-21 1999-07-01 Antex Biologics, Inc., Gaithersburg, Md. Adhesin-oligosaccharid-impfstoffkonjugate für -i(haemophilus influenza)
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
US5409705A (en) * 1991-05-20 1995-04-25 Kao Corporation Phosphobetaine and detergent and cosmetic containing the same
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
GB9202219D0 (en) * 1992-02-03 1992-03-18 Connaught Lab A synthetic heamophilus influenzae conjugate vaccine
PT647140E (pt) * 1992-06-25 2007-12-27 Univ Georgetown Vacinas de papilomavírus
US7148031B2 (en) 1994-07-26 2006-12-12 The Mitre Corporation Sequestering of glycoprotein molecules and oligosaccharide moieties in lipo-glycoprotein membranes and micelles
US5762256A (en) 1995-08-28 1998-06-09 United States Surgical Corporation Surgical stapler
US5782396A (en) * 1995-08-28 1998-07-21 United States Surgical Corporation Surgical stapler
US6032849A (en) * 1995-08-28 2000-03-07 United States Surgical Surgical stapler
SE9601158D0 (sv) * 1996-03-26 1996-03-26 Stefan Svenson Method of producing immunogenic products and vaccines
DE69708318T3 (de) * 1996-08-27 2006-11-16 Novartis Vaccines and Diagnostics, Inc., Emeryville Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
US6267961B1 (en) * 1996-11-22 2001-07-31 Baxter International Inc. Direct methods for molar-mass determination of fragments of Haemophilus influenzae type b capsular polysaccharides and vaccine preparation
CU22904A1 (es) * 1999-08-30 2004-01-23 Univ De Ottawa Oligosacáridos derivados de ribosa- ribitol-fosfato, métodos para prepararlos, inmunógenos que los comprenden y vacunas que comprenden dichos inmunógenos
US8785134B2 (en) 2008-11-10 2014-07-22 The Mitre Corporation Glycoprotein vesicles and their methods of use
AU2017302136B2 (en) 2016-07-28 2021-05-27 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against haemophilus influenzae type b
CN108776223B (zh) * 2018-04-19 2021-04-06 广州质量监督检测研究院 紫外吸收剂uv-326检测试剂盒及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220717A (en) * 1977-12-22 1980-09-02 American Cyanamid Company Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
US4264764A (en) * 1979-01-12 1981-04-28 Merck & Co., Inc. Meningitis vaccine
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4451446A (en) * 1982-03-04 1984-05-29 Smithkline-Rit Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
US4459286A (en) * 1983-01-31 1984-07-10 Merck & Co., Inc. Coupled H. influenzae type B vaccine

Also Published As

Publication number Publication date
EP0276516B1 (en) 1993-03-17
ATE87003T1 (de) 1993-04-15
NO875442L (no) 1988-07-01
IE873510L (en) 1988-06-30
NZ223009A (en) 1990-06-26
JPS63190896A (ja) 1988-08-08
EP0276516A3 (en) 1988-08-17
PT86484B (pt) 1990-11-20
KR880007557A (ko) 1988-08-27
DK694687D0 (da) 1987-12-30
DE3784907T2 (de) 1993-06-24
AU603405B2 (en) 1990-11-15
PT86484A (en) 1988-01-01
DK694687A (da) 1988-07-01
FI875727L (fi) 1988-07-01
EP0276516A2 (en) 1988-08-03
DE3784907D1 (de) 1993-04-22
FI89172C (fi) 1993-08-25
US5034519A (en) 1991-07-23
AU8314587A (en) 1988-07-07
FI89172B (fi) 1993-05-14
NO169775B (no) 1992-04-27
NO169775C (no) 1992-08-05
CA1335405C (en) 1995-04-25
IE59734B1 (en) 1994-03-23
FI875727A0 (fi) 1987-12-28
NO875442D0 (no) 1987-12-28

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