ES2055095T3 - Linfotoxina humana. - Google Patents

Linfotoxina humana.

Info

Publication number
ES2055095T3
ES2055095T3 ES89311263T ES89311263T ES2055095T3 ES 2055095 T3 ES2055095 T3 ES 2055095T3 ES 89311263 T ES89311263 T ES 89311263T ES 89311263 T ES89311263 T ES 89311263T ES 2055095 T3 ES2055095 T3 ES 2055095T3
Authority
ES
Spain
Prior art keywords
human lymphotoxin
preparations
deletion mutants
terminal deletion
lymphotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89311263T
Other languages
English (en)
Inventor
Seiichi Uesugi
Ken Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2055095T3 publication Critical patent/ES2055095T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

EL PRESENTE INVENTO SUMINISTRA MUTANTES PARA EL BORRADO DEL TERMINAL N DE LA LINFOTOXINA HUMANA QUE, A TRAVES DE LA FALTA DE LOS VEINTISIETE PRIMEROS RESIDUOS DE ACIDO AMINO CARACTERISTICA DE LA MOLECULA DE OCURRENCIA NATURAL, EXHIBEN UNA ACTIVIDAD MEJORADA. TAMBIEN SE SUMINISTRAN PREPARACIONES, USOS, METODOS DE PREPARACION, SECUENCIAS DE ACIDO NUCLEICO, ANTICUERPOS, Y PREPARACIONES DE LOS MUTANTES DE BORRADO DEL TERMINAL N DE LA LINFOTOXINA HUMANA
ES89311263T 1988-10-31 1989-10-31 Linfotoxina humana. Expired - Lifetime ES2055095T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27573288 1988-10-31

Publications (1)

Publication Number Publication Date
ES2055095T3 true ES2055095T3 (es) 1994-08-16

Family

ID=17559616

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89311263T Expired - Lifetime ES2055095T3 (es) 1988-10-31 1989-10-31 Linfotoxina humana.

Country Status (5)

Country Link
EP (1) EP0367575B1 (es)
AT (1) ATE103979T1 (es)
CA (1) CA2001756A1 (es)
DE (1) DE68914397T2 (es)
ES (1) ES2055095T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670149A (en) * 1990-06-27 1997-09-23 Biogen, Inc. Lymphotoxin-β, Lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof
JPH06501456A (ja) * 1990-06-27 1994-02-17 バイオジェン，インコーポレイテッド 表面複合リンホトキシン
US7030080B2 (en) 1990-06-27 2006-04-18 Biogen, Inc. Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
CN101600450A (zh) 2006-10-20 2009-12-09 比奥根艾迪克Ma公司 利用可溶性淋巴毒素β受体的脱髓鞘病的治疗
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212207A (en) * 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung

Also Published As

Publication number Publication date
EP0367575A1 (en) 1990-05-09
ATE103979T1 (de) 1994-04-15
DE68914397T2 (de) 1994-11-17
EP0367575B1 (en) 1994-04-06
CA2001756A1 (en) 1991-04-30
DE68914397D1 (de) 1994-05-11

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