ES2055095T3 - Linfotoxina humana. - Google Patents

Linfotoxina humana.

Info

Publication number
ES2055095T3
ES2055095T3 ES89311263T ES89311263T ES2055095T3 ES 2055095 T3 ES2055095 T3 ES 2055095T3 ES 89311263 T ES89311263 T ES 89311263T ES 89311263 T ES89311263 T ES 89311263T ES 2055095 T3 ES2055095 T3 ES 2055095T3
Authority
ES
Spain
Prior art keywords
human lymphotoxin
preparations
deletion mutants
terminal deletion
lymphotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89311263T
Other languages
English (en)
Inventor
Seiichi Uesugi
Ken Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2055095T3 publication Critical patent/ES2055095T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C07K16/242—Lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

EL PRESENTE INVENTO SUMINISTRA MUTANTES PARA EL BORRADO DEL TERMINAL N DE LA LINFOTOXINA HUMANA QUE, A TRAVES DE LA FALTA DE LOS VEINTISIETE PRIMEROS RESIDUOS DE ACIDO AMINO CARACTERISTICA DE LA MOLECULA DE OCURRENCIA NATURAL, EXHIBEN UNA ACTIVIDAD MEJORADA. TAMBIEN SE SUMINISTRAN PREPARACIONES, USOS, METODOS DE PREPARACION, SECUENCIAS DE ACIDO NUCLEICO, ANTICUERPOS, Y PREPARACIONES DE LOS MUTANTES DE BORRADO DEL TERMINAL N DE LA LINFOTOXINA HUMANA
ES89311263T 1988-10-31 1989-10-31 Linfotoxina humana. Expired - Lifetime ES2055095T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27573288 1988-10-31

Publications (1)

Publication Number Publication Date
ES2055095T3 true ES2055095T3 (es) 1994-08-16

Family

ID=17559616

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89311263T Expired - Lifetime ES2055095T3 (es) 1988-10-31 1989-10-31 Linfotoxina humana.

Country Status (5)

Country Link
EP (1) EP0367575B1 (es)
AT (1) ATE103979T1 (es)
CA (1) CA2001756A1 (es)
DE (1) DE68914397T2 (es)
ES (1) ES2055095T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157889T3 (es) * 1990-06-27 2001-09-01 Biogen Inc Linfotoxina complejada de superficie.
US5795964A (en) * 1990-06-27 1998-08-18 Biogen, Inc. Lymphotoxin-beta and lymphotoxin-beta complexes
US7030080B2 (en) 1990-06-27 2006-04-18 Biogen, Inc. Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
SG178002A1 (en) 2006-10-20 2012-02-28 Biogen Idec Inc Treatment of demyelinating disorders
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212207A (en) * 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
JPS62181298A (ja) * 1986-02-05 1987-08-08 Kyowa Hakko Kogyo Co Ltd ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) * 1986-06-20 1987-12-23 Basf Ag Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung

Also Published As

Publication number Publication date
ATE103979T1 (de) 1994-04-15
EP0367575B1 (en) 1994-04-06
DE68914397T2 (de) 1994-11-17
CA2001756A1 (en) 1991-04-30
EP0367575A1 (en) 1990-05-09
DE68914397D1 (de) 1994-05-11

Similar Documents

Publication Publication Date Title
SG47766A1 (en) CD2-binding domain of lymphocyte function associated antigen 3
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
WO2000034317A3 (en) Method for reducing immunogenicity of proteins
BG102983A (en) Extramembrane protein 106 polypeptide of moraxella catarrhalis, its gene sequence and application
DE69431060D1 (de) Klonierte glutaminsäure-decarboxylase
DE69233772D1 (de) T-zell epitopen von den wichtigsten allergene von dermatophagoides (hausmilbe)
AU5914590A (en) Muteins of human erythropoietin, the preparation thereof and the use thereof
CA2290485A1 (en) Method for the production of non-immunogenic proteins
DE69839340D1 (de) Mutanten DES VASKULÄREN, ENDOTHELZELLEN-SPEZIFISCHEN WACHSTUMSFAKTORS C (VEGF-C) UND DEREN VERWENDUNGEN
ATE449850T1 (de) Mutanten von flt3-l und ihre verwendungen
DE3750342D1 (de) Menschliches gamma-interferon-spezifisches Rezeptorprotein, Antikörper gegen dieses Protein, Verfahren zur Herstellung dieses Proteins und dieses Antikörpers und dieses Protein und diesen Antikörper enthaltende Zusammensetzungen.
EP0149548A3 (en) Nucleic acid encoding a t-cell antigen receptor polypeptide
NZ221391A (en) Microsphere compositions containing fat or wax and protein, peptide, or polypeptide
NO960309L (no) Agonister og antagonister for humaninterleukin-10
DE69518760D1 (de) Wachstumsdifferenzierungsfaktor-12
DE59101889D1 (de) Variante cd44-oberflächenproteine, diese kodierende dna-sequenzen, antikörper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie.
ATE250133T1 (de) Verktorvermittelte genominsertion und expression von dna in bcg
IL88293A0 (en) Alveolar surfactant proteins
ZA965565B (en) Novel peptides derived from human heat shock protein 60 for treatment of diabetes, compositions, methods and kits.
KR980002066A (ko) 변이형 인간 성장호르몬 및 그의 용도
CA2083177A1 (en) Alveolar surfactant proteins
MX9203138A (es) Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
EP0810285A3 (en) Mutants of human Interleukin-3
WO1993021321A3 (en) T CELL EPITOPES OF THE MAJOR ALLERGENS FROM $i(AMBROSIA ARTEMISIIFOLIA)
AU7001994A (en) Mutant polypeptide of protein kinase c, nucleic acid sequences coding for said polypeptide and use thereof

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 367575

Country of ref document: ES