ES2055371T3 - Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents
Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen.Info
- Publication number
- ES2055371T3 ES2055371T3 ES90402602T ES90402602T ES2055371T3 ES 2055371 T3 ES2055371 T3 ES 2055371T3 ES 90402602 T ES90402602 T ES 90402602T ES 90402602 T ES90402602 T ES 90402602T ES 2055371 T3 ES2055371 T3 ES 2055371T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- denotes
- general formula
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 229940124575 antispasmodic agent Drugs 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NUEVOS DERIVADOS DE LA FENOTIAZINA DE FORMULA GENERAL (I) EN LA CUAL R REPRESENTA CICLOALCOHILO CONTENIENDO DE 4 A 6 ESLABONES, O REPRESENTA -CH2R" EN LA CUAL R" ES HIDROGENO, ALCOHILO CONTENIENDO DE 1 A 5 ATOMOS DE CARBONO, ALCENILO O ALCINILO CONTENIENDO DE 2 A 4 ATOMOS DE CARBONO, CICLOALCOHILO (3 A 6 ESLABONES) FENILO EVENTUALMENTE SUSTITUIDO (POR 1 O 2 ATOMOS DE HALOGENO O POR UN RADICAL HIDROXI, ALCOHILO, ALCOHILOXI, TRIFLUOROMETILO O NITRO) O HETEROCICLILO ESCOGIDO ENTRE FURILO, TIENILO O PIRIDILO, Y R1 REPRESENTA UN RADICAL DE FORMULA GENERAL (IIA) EN LA CUAL R1 Y R2 IDENTICOS O DIFERENTES SON ALCOHILO, CICLOALCOHILO, HIDROXIALCOHILO, ACETILOXIALCOHILO O FORMANDO CONJUNTO CON EL ATOMO DE NITROGENO AL CUAL SON AGREGADOS, UN TEREROCICLO SATURADO O PARCIALMENTE INSATURADO CONTENIENDO DE 4 A 7 ESLABONES Y EVENTUALMENTE SUSTITUIDO POR 1 O 2 RADICALES ALCOHILO, HIDROXIALCOHILO O ACETILOXIALCOHILO, Y R3 ES FENETILO O ALCOHILO EVENTUALMENTE SUSTITUIDO POR CICLOALCOHILO C3 A 6 O BENZOILO, UNRADICAL DE FORMULA GENERAL (IIB) EN LA CUAL R1 Y R2 ESTAN DEFINIDOS COMO ANTERIORMENTE SE HA DICHO. LOS NUEVOS PRODUCTOS SON UTILES COMO ANTIESPASMODICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8912403A FR2652084B1 (fr) | 1989-09-21 | 1989-09-21 | Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055371T3 true ES2055371T3 (es) | 1994-08-16 |
Family
ID=9385726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90402602T Expired - Lifetime ES2055371T3 (es) | 1989-09-21 | 1990-09-20 | Derivados de fenotiazina, su preparacion y las composiciones farmaceuticas que les contienen. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5321026A (es) |
| EP (1) | EP0419360B1 (es) |
| JP (1) | JPH03120261A (es) |
| AT (1) | ATE90087T1 (es) |
| CA (1) | CA2025930A1 (es) |
| DE (1) | DE69001794T2 (es) |
| DK (1) | DK0419360T3 (es) |
| ES (1) | ES2055371T3 (es) |
| FR (1) | FR2652084B1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689013B1 (fr) * | 1992-03-30 | 1995-05-05 | Rhone Poulenc Rorer Sa | Nouvelle application thérapeutique des dérivés de la phénothiazine. |
| FR2720940A1 (fr) * | 1994-06-13 | 1995-12-15 | Rhone Poulenc Rorer Sa | Application du (+)-N-propyl [(pyrrolidinyl-1)-1 propyl-2]-10 phénothiazinecarboxamide comme antidépresseur. |
| US6284279B1 (en) | 1999-12-03 | 2001-09-04 | Avecia, Inc. | Phenothiazine in prill form and method for making the same |
| DE10032137B4 (de) * | 2000-07-01 | 2009-04-02 | Allessachemie Gmbh | Verfahren zur Herstellung von Phenothiazin-Granulat mit verbesserten Eigenschaften |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2956996A (en) * | 1960-10-18 | Alkylated phenotfflazenecarboxamede | ||
| GB860330A (en) * | 1958-04-23 | 1961-02-01 | Rhone Poulenc Sa | Improvements in or relating to phenthiazine derivatives |
| US3112310A (en) * | 1962-01-15 | 1963-11-26 | Searle & Co | 10-alkylaminoalkylphenothiazine-2-carboxamides |
| FR2632522B1 (fr) * | 1988-06-10 | 1990-09-14 | Rhone Poulenc Sante | Nouveaux derives de la phenothiazine, leur preparation et les compositions qui les contiennent |
| FR2632520B1 (fr) * | 1988-06-10 | 1990-09-14 | Rhone Poulenc Sante | Derives de la phenothiazine analgesiques |
| FR2632521B1 (fr) * | 1988-06-10 | 1990-09-14 | Rhone Poulenc Sante | Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1989
- 1989-09-21 FR FR8912403A patent/FR2652084B1/fr not_active Expired - Lifetime
-
1990
- 1990-09-20 EP EP90402602A patent/EP0419360B1/fr not_active Expired - Lifetime
- 1990-09-20 DK DK90402602.8T patent/DK0419360T3/da active
- 1990-09-20 ES ES90402602T patent/ES2055371T3/es not_active Expired - Lifetime
- 1990-09-20 DE DE90402602T patent/DE69001794T2/de not_active Expired - Fee Related
- 1990-09-20 AT AT90402602T patent/ATE90087T1/de not_active IP Right Cessation
- 1990-09-21 JP JP2253990A patent/JPH03120261A/ja active Pending
- 1990-09-21 CA CA002025930A patent/CA2025930A1/fr not_active Abandoned
-
1992
- 1992-01-27 US US07/825,753 patent/US5321026A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0419360T3 (da) | 1993-08-16 |
| EP0419360B1 (fr) | 1993-06-02 |
| DE69001794T2 (de) | 1993-09-30 |
| FR2652084A1 (fr) | 1991-03-22 |
| US5321026A (en) | 1994-06-14 |
| DE69001794D1 (de) | 1993-07-08 |
| JPH03120261A (ja) | 1991-05-22 |
| FR2652084B1 (fr) | 1991-10-31 |
| ATE90087T1 (de) | 1993-06-15 |
| EP0419360A1 (fr) | 1991-03-27 |
| CA2025930A1 (fr) | 1991-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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