ES2055744T3 - Empleo de un quelato metalico del acido etanolaminofosforico para profilaxis y terapia. - Google Patents
Empleo de un quelato metalico del acido etanolaminofosforico para profilaxis y terapia.Info
- Publication number
- ES2055744T3 ES2055744T3 ES88710021T ES88710021T ES2055744T3 ES 2055744 T3 ES2055744 T3 ES 2055744T3 ES 88710021 T ES88710021 T ES 88710021T ES 88710021 T ES88710021 T ES 88710021T ES 2055744 T3 ES2055744 T3 ES 2055744T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- ethanolaminophosphoric
- preparation
- metal
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000013522 chelant Substances 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910000000 metal hydroxide Inorganic materials 0.000 abstract 1
- 150000004692 metal hydroxides Chemical class 0.000 abstract 1
- 229910001463 metal phosphate Inorganic materials 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBE UN METALQUELATO DEL ACIDO ETANOLAMINOFOSFORICO CON LA FORMULA ESTRUCTURAL (1) EN LA QUE ME SEÑALA UN METAL ALCALINOTERREO O UN METAL DE TRANSICION ENTRE LOS QUE ESTAN MAGNESIO, CINC, COBRE, HIERRO Y MANGANO ASI COMO UN PROCESO PARA SU FABRICACION. PARA SU FABRICACION SE PREVEE UN PROCESO EN EL QUE SE MEZCLA 2 - HIDROXIETILAMINA CON UN RESTO DE ACIDO POLIFOSFORICO, CALENTANDO LA MEZCLA DESPACIO HASTA 100 (GRADOS) C A LO LARGO DE VARIAS HORAS, AÑADIENDO A UNA SOLUCION ALCALINA DEL ESTER CONSEGUIDO EL HIDROXIDO DE METAL, COLOCANDO EL PH EN 10,INTRODUCIENDO A CONTINUACION DIOXIDO DE CARBONO Y FILTRANDO EL METAL CARBONATO O EL METAL FOSFATO. EL PRINCIPIO ACTIVO PARA UN PREPARADO FARMACEUTICO PARA TRATAMIENTOS PROFILACTICOS O TERAPEUTICOS DE NEUROPATIAS CARECE DE EFECTOS SECUNDARIOS SI SE MANTIENEN LAS DOSIS PREESCRITAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873726721 DE3726721A1 (de) | 1987-08-11 | 1987-08-11 | Verwendung eines calcium-chelats der ethanolaminophosphorsaeure zur prophylaxe oder therapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055744T3 true ES2055744T3 (es) | 1994-09-01 |
Family
ID=6333531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88710021T Expired - Lifetime ES2055744T3 (es) | 1987-08-11 | 1988-08-11 | Empleo de un quelato metalico del acido etanolaminofosforico para profilaxis y terapia. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5068228A (es) |
| EP (1) | EP0303555B1 (es) |
| AT (1) | ATE107309T1 (es) |
| DE (2) | DE3726721A1 (es) |
| ES (1) | ES2055744T3 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0618968T3 (da) * | 1991-12-06 | 2000-04-10 | Max Planck Gesellschaft | Midler til diagnostisering og behandling af Alzheimer's sygdom |
| USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
| US5352683A (en) * | 1993-03-05 | 1994-10-04 | Virginia Commonwealth University Medical College Of Virginia | Method for the treatment of chronic pain |
| AU1831195A (en) * | 1994-01-13 | 1995-08-01 | Research Foundation For Mental Hygiene, Inc. | Methods and compositions for treatment and diagnosis of alzheimer disease and other disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE930566C (de) * | 1951-06-25 | 1955-07-18 | Giorgio Ferrari | Verfahren zur Herstellung von AEthanol-2-aminophosphorsaeure |
| LU43839A1 (es) * | 1963-05-31 | 1963-07-31 | ||
| US3644603A (en) * | 1968-12-30 | 1972-02-22 | Kendall & Co | Method of making 2-aminoethyl phosphate |
| DE2216000A1 (de) * | 1972-04-01 | 1973-10-11 | Koehler Chemie Dr Franz | Arzneimittel zur therapeutischen verwendung in der dermatologie und chirurgie |
-
1987
- 1987-08-11 DE DE19873726721 patent/DE3726721A1/de not_active Withdrawn
-
1988
- 1988-08-11 EP EP88710021A patent/EP0303555B1/de not_active Expired - Lifetime
- 1988-08-11 AT AT88710021T patent/ATE107309T1/de not_active IP Right Cessation
- 1988-08-11 DE DE3850186T patent/DE3850186D1/de not_active Expired - Fee Related
- 1988-08-11 US US07/231,015 patent/US5068228A/en not_active Expired - Fee Related
- 1988-08-11 ES ES88710021T patent/ES2055744T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3726721A1 (de) | 1989-02-23 |
| EP0303555A3 (en) | 1990-05-02 |
| EP0303555A2 (de) | 1989-02-15 |
| US5068228A (en) | 1991-11-26 |
| EP0303555B1 (de) | 1994-06-15 |
| DE3850186D1 (de) | 1994-07-21 |
| ATE107309T1 (de) | 1994-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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