ES2055866T3 - Derivados trifluorcetopeptidos utiles como inhibidores de elastasa de leucocitos humanos. - Google Patents
Derivados trifluorcetopeptidos utiles como inhibidores de elastasa de leucocitos humanos.Info
- Publication number
- ES2055866T3 ES2055866T3 ES90304902T ES90304902T ES2055866T3 ES 2055866 T3 ES2055866 T3 ES 2055866T3 ES 90304902 T ES90304902 T ES 90304902T ES 90304902 T ES90304902 T ES 90304902T ES 2055866 T3 ES2055866 T3 ES 2055866T3
- Authority
- ES
- Spain
- Prior art keywords
- human leukocyte
- leukocyte elastase
- trifluorcetopeptide
- derivatives useful
- peptide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 title abstract 4
- 102100033174 Neutrophil elastase Human genes 0.000 title abstract 4
- 239000003591 leukocyte elastase inhibitor Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
EL PRESENTE INVENTO SE REFIERE A CIERTOS DERIVADOS PEPTIDOS QUE SON INHIBIDORES DE LA ELASTASA DEL LEUCOCITO HUMANO, HACIENDOLES UTILES CUANDO DICHA INHIBICION SE DESEA, COMO POR EJ. EN LA INVESTIGACION DE HERRAMIENTAS EN ESTUDIOS FARMACOLOGICOS, DIAGNOSTICOS Y ESTUDIOS RELACIONADOS Y EN EL TRATAMIENTO DE ENFERMEDADES EN MAMIFEROS EN LAS CUALES ESTA IMPLICADA LA ELASTASA DEL LEUCOCITO HUMANO, INCLUYENDO TRATAMIENTOS DE ENFERMEDADES DEGENERATIVAS DE TEJIDOS TALES COMO EL ENFISEMA PULMONAR. EL INVENTO TAMBIEN INCLUYE INTERMEDIARIOS UTILES EN LA SINTESIS DE ESTOS DERIVADOS PEPTIDOS, PROCESO PARA PREPARARLOS, COMPUESTOS FARMACEUTICOS QUE LOS CONTIENEN Y METODOS PARA SU USO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898910550A GB8910550D0 (en) | 1989-05-08 | 1989-05-08 | Substituted amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055866T3 true ES2055866T3 (es) | 1994-09-01 |
Family
ID=10656402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90304902T Expired - Lifetime ES2055866T3 (es) | 1989-05-08 | 1990-05-04 | Derivados trifluorcetopeptidos utiles como inhibidores de elastasa de leucocitos humanos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5723442A (es) |
| EP (1) | EP0399688B1 (es) |
| JP (1) | JPH0356497A (es) |
| AT (1) | ATE107659T1 (es) |
| AU (1) | AU622315B2 (es) |
| CA (1) | CA2016208A1 (es) |
| DE (1) | DE69010079T2 (es) |
| DK (1) | DK0399688T3 (es) |
| ES (1) | ES2055866T3 (es) |
| GB (1) | GB8910550D0 (es) |
| IE (1) | IE63534B1 (es) |
| ZA (1) | ZA903342B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910547D0 (en) * | 1989-05-08 | 1989-06-21 | Ici America Inc | Substituted ketones |
| CA2021660A1 (en) * | 1989-07-26 | 1991-01-27 | Philippe Bey | Peptidase inhibitors |
| GB9214053D0 (en) * | 1992-07-02 | 1992-08-12 | Ici Plc | Heterocyclic amides |
| US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256761A (en) * | 1979-07-13 | 1981-03-17 | Usv Pharmaceutical Corporation | Antihypertensive amides |
| US4820729A (en) * | 1981-03-30 | 1989-04-11 | Rorer Pharmaceutical Corporation | N-substituted-amido-amino acids |
| US5194588A (en) * | 1985-01-22 | 1993-03-16 | Ici Americas Inc. | Aminoalcohol intermediates for peptide derivatives |
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| EP0276101A3 (en) * | 1987-01-19 | 1989-11-23 | Ici Americas Inc. | Substituted peptide derivatives |
| GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
| EP0369391A3 (en) * | 1988-11-15 | 1991-09-25 | Boehringer Ingelheim Pharmaceuticals Inc. | N-substituted amides |
| GB8910547D0 (en) * | 1989-05-08 | 1989-06-21 | Ici America Inc | Substituted ketones |
| US5221665A (en) * | 1989-10-27 | 1993-06-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | N-substituted amides |
-
1989
- 1989-05-08 GB GB898910550A patent/GB8910550D0/en active Pending
-
1990
- 1990-05-01 AU AU54561/90A patent/AU622315B2/en not_active Ceased
- 1990-05-02 ZA ZA903342A patent/ZA903342B/xx unknown
- 1990-05-04 DK DK90304902.1T patent/DK0399688T3/da active
- 1990-05-04 ES ES90304902T patent/ES2055866T3/es not_active Expired - Lifetime
- 1990-05-04 AT AT90304902T patent/ATE107659T1/de not_active IP Right Cessation
- 1990-05-04 EP EP90304902A patent/EP0399688B1/en not_active Expired - Lifetime
- 1990-05-04 DE DE69010079T patent/DE69010079T2/de not_active Expired - Fee Related
- 1990-05-07 CA CA002016208A patent/CA2016208A1/en not_active Abandoned
- 1990-05-07 IE IE165290A patent/IE63534B1/en not_active IP Right Cessation
- 1990-05-08 JP JP2118527A patent/JPH0356497A/ja active Pending
-
1993
- 1993-04-07 US US08/043,616 patent/US5723442A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5723442A (en) | 1998-03-03 |
| IE901652L (en) | 1990-11-08 |
| IE63534B1 (en) | 1995-05-17 |
| AU622315B2 (en) | 1992-04-02 |
| AU5456190A (en) | 1990-11-08 |
| GB8910550D0 (en) | 1989-06-21 |
| ZA903342B (en) | 1991-01-30 |
| DE69010079T2 (de) | 1994-10-13 |
| CA2016208A1 (en) | 1990-11-08 |
| EP0399688B1 (en) | 1994-06-22 |
| EP0399688A1 (en) | 1990-11-28 |
| DE69010079D1 (de) | 1994-07-28 |
| JPH0356497A (ja) | 1991-03-12 |
| DK0399688T3 (da) | 1994-08-29 |
| ATE107659T1 (de) | 1994-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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