ES2056837T3 - Procedimiento para preparar una composicion oral farmaceutica de liberacion controlada. - Google Patents

Procedimiento para preparar una composicion oral farmaceutica de liberacion controlada.

Info

Publication number
ES2056837T3
ES2056837T3 ES87830347T ES87830347T ES2056837T3 ES 2056837 T3 ES2056837 T3 ES 2056837T3 ES 87830347 T ES87830347 T ES 87830347T ES 87830347 T ES87830347 T ES 87830347T ES 2056837 T3 ES2056837 T3 ES 2056837T3
Authority
ES
Spain
Prior art keywords
preparing
procedure
controlled release
oral composition
release pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87830347T
Other languages
English (en)
Inventor
Roberto Valducci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2056837T3 publication Critical patent/ES2056837T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
  • Color Television Systems (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Prostheses (AREA)
  • Laminated Bodies (AREA)
  • Materials For Medical Uses (AREA)
  • Pens And Brushes (AREA)
  • External Artificial Organs (AREA)

Abstract

SE PROPORCIONA UNA MEMBRANA DE REVESTIMIENTO PARA COMPUESTOS FARMACEUTICOS, VETERINARIOS, COSMETICOS SINTETICOS Y EXTRACTIVOS, QUE COMPRENDE UNA SUSTANCIA LIPOFILA, SOLA O EN MEZCLA CON UN AGENTE DE ENDURECIMIENTO, DONDE LA SUSTANCIA LIPOFILA SE ELIGE DE ACIDOS GRASOS DE 12 A 20 ATOMOS DE CARBONO Y PARAFINA, Y EL ENDURECEDOR SE ELIGE DE ETERES O ESTERES DE CELULOSA, COPOLIMEROS DE ACIDO METACRILICO, POLIETILENGLICOL, POLIVINILPIRROLIDONA, POLIVINILACTOFTALATO Y POLIVINILACETATO.
ES87830347T 1986-09-30 1987-09-29 Procedimiento para preparar una composicion oral farmaceutica de liberacion controlada. Expired - Lifetime ES2056837T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03530/86A IT1200217B (it) 1986-09-30 1986-09-30 Membrana per uso farmaceutico ed industriale

Publications (1)

Publication Number Publication Date
ES2056837T3 true ES2056837T3 (es) 1994-10-16

Family

ID=11109126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87830347T Expired - Lifetime ES2056837T3 (es) 1986-09-30 1987-09-29 Procedimiento para preparar una composicion oral farmaceutica de liberacion controlada.

Country Status (18)

Country Link
US (1) US5149542A (es)
EP (1) EP0263083B1 (es)
JP (1) JP2518882B2 (es)
KR (1) KR880701542A (es)
CN (1) CN1062444C (es)
AT (1) ATE90871T1 (es)
AU (1) AU602931B2 (es)
CA (1) CA1313132C (es)
DE (1) DE3786316T2 (es)
DK (1) DK174949B1 (es)
ES (1) ES2056837T3 (es)
FI (1) FI882524L (es)
HU (1) HU201684B (es)
IT (1) IT1200217B (es)
NZ (1) NZ221987A (es)
PT (1) PT85819B (es)
WO (1) WO1988002253A1 (es)
ZA (1) ZA877316B (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation
IT1197316B (it) * 1986-10-01 1988-11-30 Proter Spa Formulazione galenica ad uso orale di derivati della reina a lento rilascio per impiego terapeutico
US4894231A (en) * 1987-07-28 1990-01-16 Biomeasure, Inc. Therapeutic agent delivery system
DE3737741A1 (de) * 1987-11-06 1989-05-18 Goedecke Ag Oral anzuwendende arzneiform zur einmal taeglichen behandlung der hypertonie mit diltiazemhydrochlorid
DE3922167A1 (de) * 1988-04-16 1991-01-17 Sanol Arznei Schwarz Gmbh Oral zu verabreichende diltiazemhydrochlorid enthaltende pharmazeutische zubereitung zur einmal taeglichen applikation und verfahren zu deren herstellung
US5344657A (en) * 1988-04-27 1994-09-06 Elf Sanofi Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them
DE3822095A1 (de) * 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab Neue arzneimittelformulierung sowie verfahren zu deren herstellung
US5296236A (en) * 1988-09-16 1994-03-22 Recordati S.A., Chemical And Pharmaceutical Company Controlled release therapeutic system for a liquid pharmaceutical formulations
IT1226940B (it) * 1988-09-16 1991-02-22 Recordati Chem Pharm Sistema terapeutico a rilascio controllato per formulazioni farmaceutiche liquide
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US4966770A (en) * 1989-07-26 1990-10-30 Himedics, Inc. Prednisone microencapsulated granules
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
ZA923474B (en) * 1991-05-20 1993-01-27 Marion Merrell Dow Inc Diltiazem formulation
US5286497A (en) * 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
GB2258613B (en) * 1991-08-12 1996-01-10 Euro Celtique Sa Pharmaceutical diltiazem formulation
KR100221695B1 (ko) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
WO1993017673A1 (en) * 1992-03-03 1993-09-16 Top Gold Pty., Limited Sustained release analgesics
DE4313726A1 (de) * 1993-04-27 1994-11-03 Byk Nederland Bv Feste Darreichungsform
US5834024A (en) 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
KR100417746B1 (ko) 1995-07-21 2004-05-31 다이이찌 세이야꾸 가부시기가이샤 입상제제의제조방법
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US5830503A (en) * 1996-06-21 1998-11-03 Andrx Pharmaceuticals, Inc. Enteric coated diltiazem once-a-day formulation
WO1998014179A1 (en) * 1996-10-01 1998-04-09 Cima Labs Inc. Taste-masked microcapsule compositions and methods of manufacture
KR100522248B1 (ko) * 1997-05-29 2006-02-01 동아제약주식회사 이중제어방출막구조의경구서방성제제및그제조방법
US6004582A (en) * 1997-05-30 1999-12-21 Laboratorios Phoenix U.S.A, Inc. Multi-layered osmotic device
US6197347B1 (en) * 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
WO2000022909A2 (en) * 1998-10-19 2000-04-27 Biotech Australia Pty. Limited Systems for oral delivery
JP2000198747A (ja) * 1998-10-26 2000-07-18 Tanabe Seiyaku Co Ltd 徐放性粒子
CA2347104A1 (en) * 1998-10-26 2000-04-05 Tanabe Seiyaku Co., Ltd. Sustained-release particles
FR2795962B1 (fr) * 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
US7108866B1 (en) 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof
US20060153914A1 (en) * 1999-12-10 2006-07-13 Biovail Laboratories International S.R.L. Chronotherapeutic diltiazem formulations and the administration thereof
US6635277B2 (en) 2000-04-12 2003-10-21 Wockhardt Limited Composition for pulsatile delivery of diltiazem and process of manufacture
PT1276470E (pt) 2000-04-20 2007-08-13 Novartis Ag Composição de revestimento para dissimular o sabor
IL136899A0 (en) * 2000-06-20 2001-06-14 Caretec Ltd Microcapsules containing arginine and the different uses thereof
KR100411195B1 (ko) * 2000-09-26 2003-12-18 한국화학연구원 케토롤락 트로메타민이 함유된 서방형 펠렛
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US6592901B2 (en) * 2001-10-15 2003-07-15 Hercules Incorporated Highly compressible ethylcellulose for tableting
ES2314227T7 (es) 2002-04-09 2012-11-19 Flamel Technologies Formulacion farmaceutica oral en forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de amoxilicina.
JP4732696B2 (ja) 2002-04-09 2011-07-27 フラメル・テクノロジー 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US8420115B2 (en) 2004-06-03 2013-04-16 Taisho Pharmaceutical Co., Ltd. Oral preparations and process for production thereof
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
WO2006047493A2 (en) 2004-10-21 2006-05-04 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
EP2471515A3 (en) 2007-09-14 2012-12-26 Wockhardt Limited Rhein or diacerein compositions
CA2926563A1 (en) 2007-09-27 2009-04-02 Wockhardt Research Centre Pharmaceutical compositions of rhein or diacerein
US20100285114A1 (en) * 2007-09-27 2010-11-11 Rahul Dabre Pharmaceutical compositions of rhein or diacerein
SG10201407965XA (en) 2009-12-02 2015-02-27 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
CA3018328A1 (en) * 2014-10-31 2016-04-30 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
CN115192553B (zh) * 2022-07-29 2026-05-08 山东齐都药业有限公司 单硝酸异山梨酯口溶膜制剂及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB595444A (en) * 1945-07-09 1947-12-04 Gwilym Lloyd Thomas Improvements in or relating to medicaments, and to the preparation thereof
CH283585A (de) * 1950-03-15 1952-06-15 Hoffmann La Roche Zur Herstellung von Tablettenüberzügen geeignetes Gemisch.
US2828206A (en) * 1954-02-24 1958-03-25 Roseuberg Adolf Stabilized fat-soluble vitamins and methods of making same
US2918411A (en) * 1957-11-01 1959-12-22 Olin Mathieson Pharmaceutical preparations
NL270408A (es) * 1960-10-20
US3078216A (en) * 1961-04-11 1963-02-19 American Cyanamid Co Prolonged release oral pharmaceutical preparations
FR1329120A (fr) * 1961-06-13 1963-06-07 Abbott Lab Comprimés revêtus d'un revêtement plastique mince, compositions de revêtement pour comprimés et méthode de revêtement des comprimés
BE644643A (es) * 1963-03-04 1964-09-03
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
US3492397A (en) * 1967-04-07 1970-01-27 Warner Lambert Pharmaceutical Sustained release dosage in the pellet form and process thereof
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
BE838505A (fr) * 1976-02-12 1976-05-28 Utilisation de l'uree de granules enrobes de soufre comme source d'azote non proteique pour les ruminants
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
PH18946A (en) * 1983-04-21 1985-11-14 Elan Corp Plc Controlled absorption pharmaceutical composition

Also Published As

Publication number Publication date
DK246388D0 (da) 1988-05-06
NZ221987A (en) 1990-07-26
KR880701542A (ko) 1988-11-03
AU8025987A (en) 1988-04-21
EP0263083B1 (en) 1993-06-23
HUT49815A (en) 1989-11-28
AU602931B2 (en) 1990-11-01
IT8603530A0 (it) 1986-09-30
FI882524A7 (fi) 1988-05-27
FI882524A0 (fi) 1988-05-27
FI882524L (fi) 1988-05-27
PT85819B (pt) 1990-08-31
US5149542A (en) 1992-09-22
DK174949B1 (da) 2004-03-22
PT85819A (en) 1987-10-01
JPH01500998A (ja) 1989-04-06
EP0263083A1 (en) 1988-04-06
CN1062444C (zh) 2001-02-28
DE3786316T2 (de) 1993-10-28
IT1200217B (it) 1989-01-05
CA1313132C (en) 1993-01-26
DK246388A (da) 1988-05-26
ZA877316B (en) 1988-06-29
ATE90871T1 (de) 1993-07-15
CN87107792A (zh) 1988-06-29
HU201684B (en) 1990-12-28
DE3786316D1 (de) 1993-07-29
JP2518882B2 (ja) 1996-07-31
WO1988002253A1 (en) 1988-04-07

Similar Documents

Publication Publication Date Title
KR880701542A (ko) 코팅 막과 그로부터 조제된 조성물
ES513340A0 (es) Procedimiento para preparar una composicion farmaceutica topica que contiene una mezcla de un agente antimicrobiano de acido graso y un corticosteroide.
ES557835A0 (es) Un procedimiento para preparar una formulacion farmaceutica que contiene 3'-azido-3'-desoxitimidina o uno de sus derivados farmaceuticamente aceptables.
ES8308212A1 (es) Un procedimiento de preparacion de una composicion farmaceutica topica que contiene un agente antimicrobiano de acido graso.
DK196189A (da) Oralt osmotisk dispenseringssystem indeholdende et farmakologisk aktivt stof
ES2065059T3 (es) Composicion farmaceutica de florfenicol.
MX9204268A (es) Una composicion para la liberacion prolongada y controlada de substancias medicamentosas y un proceso para preparar la misma.
DE3880762D1 (de) Orale, acetaminophen enthaltende zusammensetzung mit gesteuerter arzneistoff-freisetzung und verfahren zu ihrer herstellung.
BR8603822A (pt) Dispositivo distribuidor para liberacao de uma formulacao de agente benefico a um ambiente de uso
BR8603678A (pt) Dispositivo distribuidor para liberacao de uma formulacao de agente benefico a um ambiente de uso
BR8205913A (pt) Composicao para o revestimento de uma substancia biologicamente ativa e granulados destinados a serem administrados pro via oral a animais
SE8206731L (sv) Ester- och amid-derivat av 13,14-didehydro-prostaglandiner
DE3460035D1 (en) 1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and formulations containing it
SE8701479L (sv) Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
AT281842B (de) Verfahren zur herstellung von neuen 10,11-dihydro-di-benzo <b,f>-azepinderivaten sowie von deren saeureadditionssalzen und quaternaeren ammoniumverbindungen
ES2054029T3 (es) Formulacion de acetato de flecainida con liberacion controlada.
BE877050A (fr) Utilisation d'esters d'acides hydroxycarboxyliques aliphatiques en tant que desodorisants
SE8002244L (sv) Nytt 1alfa,25-dihydroxi-cholekalciferolderivat, sett for framstellning samt anvendning derav som lekemedel och farmaceutiska kompositioner inehallande denna forening
AT301551B (de) Verfahren zur Herstellung von neuen (1,2,3,4-Tetrahydro-6-chinolyl)essigsäuren, deren Estern und stickstoffhaltigen Derivaten, sowie deren Isomeren, optischen Antipoden und Salzen
SE9004169D0 (sv) Anvaendning av farmaceutiska och kosmetiska kompositioner, innehaallande 1,8-dihydroxi-10-fenyl-9-antron som verksam bestaandsdel
AR219363A1 (es) Procedimiento para la preparacion de derivados 4"-amino sustituidos de oleandomicina,sus esteres ii-monoalcanoilicos,a monoalcanoilicos y ii,2'-dialcanoilicos que contienen en la posicion 4"un grupo amino sustituido con c(0)-c(0)-r3 o-c(zs)-(c=0)-r
AT327217B (de) Verfahren zur herstellung von neuen n-aryl-carbamidsaure-(imidazolyl-(1)-methyl)-estern und ihren physiologisch vertraglichen saureadditionssalzen
ES8405784A1 (es) Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
AT310735B (de) Verfahren zur Herstellung von neuen 2-(3,4-Dimethyl-cumarin-7-yl)-oxy-alkylcarbonsäure-Derivate und ihrer Salze
ES557209A0 (es) Un procedimiento para preparar una formulacion farmaceutica que contiene 3'-azido-3'-desoxitimidina o uno de sus derivados farmaceuticamente aceptables.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 263083

Country of ref document: ES