ES2056875T3 - Metodos y materiales para la preparacion de soluciones de anticuerpos marcados con metales. - Google Patents

Metodos y materiales para la preparacion de soluciones de anticuerpos marcados con metales.

Info

Publication number
ES2056875T3
ES2056875T3 ES88118414T ES88118414T ES2056875T3 ES 2056875 T3 ES2056875 T3 ES 2056875T3 ES 88118414 T ES88118414 T ES 88118414T ES 88118414 T ES88118414 T ES 88118414T ES 2056875 T3 ES2056875 T3 ES 2056875T3
Authority
ES
Spain
Prior art keywords
metals
preparation
materials
methods
antibody solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88118414T
Other languages
English (en)
Inventor
David K Johnson
Patrick E Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26816013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2056875(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/118,148 external-priority patent/US5130118A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2056875T3 publication Critical patent/ES2056875T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN PROCEDIMIENTO DEL BARRIDO CON IONES METALICOS Y COMPOSICIONES ANTICUERPO PARA RADIOINMUNOESCINTIGRAFIA Y RADIOINMUNOTERAPIA CITOTOXICA QUE TIENEN CONCENTRACIONES DE QUELATADOR DE MAS DE 10EXP -4 M QUE SON OPTIMIZADAS CON RESPECTO A SU CAPACIDAD DE UNION DE METALES DE TAL MODO QUE SE CONSIGUE UN MARCADO ALTAMENTE EFICIENTE DEL ANTICUERPO EN UN PROCEDIMIENTO SIMPLE DE UN ETAPA UTILIZANDO FUENTES FACILMENTE OBTENIBLES DE IONES DE RADIOMETALES.
ES88118414T 1987-11-06 1988-11-04 Metodos y materiales para la preparacion de soluciones de anticuerpos marcados con metales. Expired - Lifetime ES2056875T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/118,148 US5130118A (en) 1987-11-06 1987-11-06 Methods and materials for the preparation of metal labelled antibody solutions
US26173788A 1988-10-26 1988-10-26

Publications (1)

Publication Number Publication Date
ES2056875T3 true ES2056875T3 (es) 1994-10-16

Family

ID=26816013

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88118414T Expired - Lifetime ES2056875T3 (es) 1987-11-06 1988-11-04 Metodos y materiales para la preparacion de soluciones de anticuerpos marcados con metales.

Country Status (7)

Country Link
EP (1) EP0315188B1 (es)
JP (2) JP2792871B2 (es)
KR (1) KR890007756A (es)
AT (1) ATE106252T1 (es)
AU (1) AU619218B2 (es)
DE (1) DE3889851T2 (es)
ES (1) ES2056875T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
EP0403243B1 (en) * 1989-06-16 1995-11-08 Merck Frosst Canada Inc. Chelate derivatives of atrial natriuretic factor (ANF)
CA2066779A1 (en) * 1989-09-22 1991-03-23 Jean-Luc Vanderheyden Stable therapeutic radionuclide compositions and methods for preparation thereof
EP0709100A1 (en) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Contrast agent, containing several detection groups per molecule
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US7514078B2 (en) 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
WO2002098897A2 (en) 2001-06-01 2002-12-12 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
EP1277728A1 (en) * 2001-07-18 2003-01-22 University of Lausanne Novel TTDA derivatives and their use as gadolinium chelators for MRI imaging
EP1427377A4 (en) 2001-09-20 2006-04-12 Cornell Res Foundation Inc METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING SKIN DISORDERS USING SPECIFIC BINDING AGENTS FOR A PROSTATE-SPECIFIC MEMBRANE ANTIGEN
ATE408712T1 (de) 2003-01-10 2008-10-15 Millennium Pharm Inc Verfahren zur bestimmung des wiederauftretens von prostata krebs
JP7816003B2 (ja) * 2022-06-06 2026-02-18 Ｊｆｅエンジニアリング株式会社 放射性物質の標識方法
EP4583999A1 (en) * 2022-09-09 2025-07-16 Bristol-Myers Squibb Company Methods of separating chelator

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122641B (en) * 1982-06-07 1986-08-06 Otto A Gansow Metal chelate conjugated monoclonal antibodies where in the metal is an emitter
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4636380A (en) * 1984-04-23 1987-01-13 Wong Dennis W Novel physiologic chemical method of labeling protein substances with the radionuclides of indium
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments

Also Published As

Publication number Publication date
JP3074160B2 (ja) 2000-08-07
DE3889851T2 (de) 1994-09-08
JPH10330289A (ja) 1998-12-15
DE3889851D1 (de) 1994-07-07
KR890007756A (ko) 1989-07-05
AU2466488A (en) 1989-07-27
EP0315188A2 (en) 1989-05-10
JPH01250327A (ja) 1989-10-05
JP2792871B2 (ja) 1998-09-03
EP0315188B1 (en) 1994-06-01
ATE106252T1 (de) 1994-06-15
AU619218B2 (en) 1992-01-23
EP0315188A3 (en) 1990-01-10

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