ES2057537T3 - Sistema de dosificacion con emision continuada. - Google Patents

Sistema de dosificacion con emision continuada.

Info

Publication number
ES2057537T3
ES2057537T3 ES90903536T ES90903536T ES2057537T3 ES 2057537 T3 ES2057537 T3 ES 2057537T3 ES 90903536 T ES90903536 T ES 90903536T ES 90903536 T ES90903536 T ES 90903536T ES 2057537 T3 ES2057537 T3 ES 2057537T3
Authority
ES
Spain
Prior art keywords
bioactive
continuous
bioactive agent
release
released
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90903536T
Other languages
English (en)
Inventor
Loui J Silvestri
Ruth H Pyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosearch Inc
Original Assignee
Biosearch Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosearch Inc filed Critical Biosearch Inc
Application granted granted Critical
Publication of ES2057537T3 publication Critical patent/ES2057537T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE UN SISTEMA DE SUMINISTRO INYECTABLE DE LIBERACION CONTINUA Y MULTIFASICA, ASI COMO UN METODO PARA EL TRATAMIENTO DE SERES HUMANOS Y OTROS MAMIFEROS CON ESTE SISTEMA DE LIBERACION CONTINUA Y MULTIFASICA. EL SISTEMA DE LIBERACION CONTINUA Y MULTIFASICA INCLUYE EL SUMINISTRO PROLONGADO Y CONTROLADO DE AGENTE BIOACTIVO, MACROMOLECULAR Y MICROENCAPSULADO DE ORIGEN BIOLOGICO QUE CONTIENE EL AGENTE BIOACTIVO ENCAPSULADO EN MICROCAPSULAS DE POLIMERO ENCAPSULANTE BIOCORROSIBLE, QUE PERMITE UNA LIBERACION MULTIFASICA Y CONTINUA DE DICHO AGENTE BIOACTIVO, INCLUYENDO (I) UNA PRIMERA PARTE DE DICHO AGENTE BIOACTIVO QUE AL SER INYECTADO PUEDE SER LIBERADO DE DICHAS MICROCAPSULAS DE POLIMERO ENCAPSULANTE BIOCORROSIBLE DE UNA FORMA POR LA QUE SOLO UNA CANTIDAD RELATIVAMENTE PEQUEÑA DE DICHO AGENTE BIOACTIVO SEA LIBERADA DURANTE BIOLOGICA INICIAL ES MINIMIZADA DEBIDO A QUE ESTA PRIMERA PARTE PRODUCE UNA REACCION LIGERA SIMILAR A LA QUE SE OBSERVA NORMALMENTE CON DOSIS BAJAS DE ADMINISTRACION CONVENCIONAL; Y (II) PARTES SECUNDARIAS DE DICHO AGENTE BIOACTIVO QUE PROPORCIONAN UN NIVEL DE AGENTE BIOACTIVO SUSTANCIALMENTE MAS ELEVADO EN DOSIS QUE PROVOCARIAN UNA REACCION SERIA EN EL PACIENTE, SI NO FUERA POR LA LIBERACION ANTERIOR DE LA PRIMERA PARTE MENCIONADA.
ES90903536T 1989-02-08 1990-02-08 Sistema de dosificacion con emision continuada. Expired - Lifetime ES2057537T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/308,225 US4990336A (en) 1989-02-08 1989-02-08 Sustained release dosage form

Publications (1)

Publication Number Publication Date
ES2057537T3 true ES2057537T3 (es) 1994-10-16

Family

ID=23193090

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90903536T Expired - Lifetime ES2057537T3 (es) 1989-02-08 1990-02-08 Sistema de dosificacion con emision continuada.

Country Status (8)

Country Link
US (1) US4990336A (es)
EP (1) EP0457834B1 (es)
AT (1) ATE106716T1 (es)
AU (1) AU5109190A (es)
DE (1) DE69009743T2 (es)
DK (1) DK0457834T3 (es)
ES (1) ES2057537T3 (es)
WO (1) WO1990009166A1 (es)

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US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
ES2181691T5 (es) * 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) * 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5686092A (en) * 1992-11-24 1997-11-11 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
WO1994012158A1 (en) * 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
DE69415684T2 (de) * 1993-10-22 1999-06-10 Genentech Inc., San Francisco, Calif. Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
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US5540927A (en) * 1995-04-12 1996-07-30 Monsanto Company Microencapsulation process by coacervation
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
EP0850051A2 (en) * 1995-08-31 1998-07-01 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US6074673A (en) * 1996-04-22 2000-06-13 Guillen; Manuel Slow-release, self-absorbing, drug delivery system
US5762943A (en) * 1996-05-14 1998-06-09 Ribi Immunochem Research, Inc. Methods of treating type I hypersensitivity using monophosphoryl lipid A
EP1690531A3 (en) * 1996-09-30 2010-01-20 Alza Corporation Dosage form and method for administering drug
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
FR2822709B1 (fr) * 2001-03-30 2007-01-19 Antialis Composition pharmaceutique anti-allergique comprenant au moins un allergene et au moins un compose antihistaminique
FR2822708A1 (fr) * 2001-03-30 2002-10-04 Antialis Composition pharmaceutique anti-allergique comprenant au moins un allergene et au moins un compose antihistaminique
US7858093B1 (en) * 2004-10-29 2010-12-28 Iowa State University Research Foundation, Inc. Controlled-release immunogenic formulations to modulate immune response

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Also Published As

Publication number Publication date
AU5109190A (en) 1990-09-05
ATE106716T1 (de) 1994-06-15
DK0457834T3 (da) 1994-10-31
EP0457834B1 (en) 1994-06-08
DE69009743D1 (de) 1994-07-14
EP0457834A1 (en) 1991-11-27
EP0457834A4 (en) 1992-01-22
US4990336A (en) 1991-02-05
DE69009743T2 (de) 1994-11-03
WO1990009166A1 (en) 1990-08-23

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