ES2058023A1 - Derivados del acido 4-hidroxi-butirico. - Google Patents
Derivados del acido 4-hidroxi-butirico.Info
- Publication number
- ES2058023A1 ES2058023A1 ES09202177A ES9202177A ES2058023A1 ES 2058023 A1 ES2058023 A1 ES 2058023A1 ES 09202177 A ES09202177 A ES 09202177A ES 9202177 A ES9202177 A ES 9202177A ES 2058023 A1 ES2058023 A1 ES 2058023A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxybutyric acid
- ch2oh
- treatment
- derivatives
- carbons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical class OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title abstract 3
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 208000001573 Cataplexy Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 206010039897 Sedation Diseases 0.000 abstract 1
- 208000010513 Stupor Diseases 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 238000001949 anaesthesia Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004292 cyclic ethers Chemical class 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 150000002780 morpholines Chemical class 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036280 sedation Effects 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
DERIVADOS DEL ACIDO 4-HIDROXIBUTIRICO, DE FORMULAS I Y II, EN DONDE RSI1 SC, RSI2 SC Y RSI3 SC SIGNIFICAN LOS RADICALES H-, CHSI3 SC-, CSI2 SCHSI5 SC-, CHSI2 SCOH-CHSI2 SC-, O CHSI2 SCOH-CHOH-CHSI2 SC-, O CON EL NITROGENO FORMAN UN HETEROCICLOALCANO CON 4 O 5 CARBONOS, SIENDO RSI4 SC UN ALCOHOL O POLIALCOHOL CON 1-5 CARBONOS Y 1-5 OXIGENOS, LINEAL O RAMIFICADO, O EN FORMA DE ANILLO, Y RSI1 SC Y RSI4 SC PUEDEN ESTAR CONDENSADOS ENTRE SI PARA FORMAR UN ETER CICLICO, Y RSI5 SC Y RSI6 SC INDEPENDIENTEMENTE SON H- O CHSI2 SCOH-. LAS SALES O AMIDAS DEL ACIDO GAMMAHIDROXIBUTIRICO SE OBTIENEN POR REACCION DE GAMMA-BUTIROLACTONA CON UN AMINOALCOHOL O UN DERIVADO DE LA MORFOLINA, AJUSTANDO EL PH A 7,5. ESTOS COMPUESTOS SE USAN EN PREPARACIONES PARENTERALES U ORALES PARA LA NARCOSIS EN LA ANESTESIA, PARA LA INDUCCION AL SUEÑO O SEDACION, PARA LA TERAPIA DE LA DESINTOXICACION ALCOHOLICA, PARA LA TERAPIA DE LA CATAPLEJIA O NARCOLEPSIA, Y PARA LA TERAPIA DE TRASTORNOS DEL SUEÑO.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9202177A ES2058023B1 (es) | 1992-10-29 | 1992-10-29 | Derivados del acido 4-hidroxi-butirico. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9202177A ES2058023B1 (es) | 1992-10-29 | 1992-10-29 | Derivados del acido 4-hidroxi-butirico. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2058023A1 true ES2058023A1 (es) | 1994-10-16 |
| ES2058023B1 ES2058023B1 (es) | 1995-10-01 |
Family
ID=8278609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9202177A Expired - Fee Related ES2058023B1 (es) | 1992-10-29 | 1992-10-29 | Derivados del acido 4-hidroxi-butirico. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2058023B1 (es) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4143159A (en) * | 1976-07-12 | 1979-03-06 | Henkel Kommanditgesellschaft Auf Aktien | Skin-care agents containing hydroxyalkyl carboxamides and process |
| ES8306360A1 (es) * | 1980-07-17 | 1983-06-01 | Klosa Josef | Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico. |
| EP0398272A1 (en) * | 1989-05-19 | 1990-11-22 | Kao Corporation | Amide derivatives and dermatologic preparations containing the same |
| WO1992019581A1 (de) * | 1991-04-29 | 1992-11-12 | Dr. Franz Köhler Chemie GmbH | Derivate der 4-hydroxy-buttersäure |
-
1992
- 1992-10-29 ES ES9202177A patent/ES2058023B1/es not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4143159A (en) * | 1976-07-12 | 1979-03-06 | Henkel Kommanditgesellschaft Auf Aktien | Skin-care agents containing hydroxyalkyl carboxamides and process |
| ES8306360A1 (es) * | 1980-07-17 | 1983-06-01 | Klosa Josef | Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico. |
| EP0398272A1 (en) * | 1989-05-19 | 1990-11-22 | Kao Corporation | Amide derivatives and dermatologic preparations containing the same |
| WO1992019581A1 (de) * | 1991-04-29 | 1992-11-12 | Dr. Franz Köhler Chemie GmbH | Derivate der 4-hydroxy-buttersäure |
Non-Patent Citations (1)
| Title |
|---|
| S. BUDAVARI et al.: "The Merck Index, an encyclopedia of Chemicals, Drugs and Biologicals", 11 edición, 1989, Merck & Co., Inc., Rahway, NJ, US, pág. 1365, parágrafo 8603 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2058023B1 (es) | 1995-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8401443A1 (es) | "un procedimiento para preparar derivados de tetralina". | |
| GR3031492T3 (en) | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | |
| HU9501329D0 (en) | Novel 3,3-diphenylpropylamines, their use and preparation | |
| ATE217635T1 (de) | Zyklische peptide mit antifungischer wirkung und verfahren zu ihrer herstellung | |
| NO174296C (no) | Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner | |
| PT98064A (pt) | Processo para a preparacao de novos compostos anti-epilepticos, nomeadamente acidos aminoalcanofosfinicos n-substituidos | |
| DE3370585D1 (en) | Use of aminophenylacetic acid derivatives for the manufacture of an immunomodulating medical preparation | |
| PT93825A (pt) | Processo para a preparacao de derivados da piperazina | |
| ZA953877B (en) | Novel process | |
| ES2081777A6 (es) | Nuevos derivados de acido d,l-glutamico y acido d,l-aspartico | |
| PT90905A (pt) | Processo para a preparacao de derivados condensados de pizanol-3-oxo- propanonitrilo | |
| TW355705B (en) | Substituted benzyloxycarbonylguanidines, process for their preparation, their medical use and pharmaceutical composition containing them | |
| GR3001874T3 (en) | Process for the preparation of n-alkylated amino acids and their esters, use in the synthesis of carboxyalkyl dipeptides | |
| ES2058023A1 (es) | Derivados del acido 4-hidroxi-butirico. | |
| HUT34480A (en) | Process for preparing new beta-carboline derivatives and pharmaceutical compositions containing thereof | |
| HUT70052A (en) | Process for producing pharmaceutical compositions containing pirimidone derivatives in the treatment of certain airway or skin diseases | |
| DK0514357T3 (da) | Anvendelse af estere af acyl-L-carnitiner med gamma-hydroxysmørsyre til fremstilling af farmaceutiske præparater til behandling af hepatopatier | |
| ES488988A0 (es) | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos | |
| DE3752272D1 (de) | Verwendung eines Thioesters zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen | |
| DE3786865D1 (de) | Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate. | |
| FI94630B (fi) | Analogiamenetelmä terapeuttisesti käyttökelpoisten N,N'-bis(alkoksi- ja hydroksialkyyli)pyridiini-2,4-dikarboksyylihappodiamidien valmistamiseksi | |
| ES2007281A6 (es) | Procedimiento de preparacion de nuevos derivados de benzamida. | |
| HUT44471A (en) | Process for production of derivatives of 8-/short carbon chained alkyl/-bicyclo /4,2,0/-octane, their salts and esthers and medical preparatives containing them as active substance | |
| MY123317A (en) | Synthesis of chiral beta-amino acids | |
| PT83142A (en) | Process for the preparation of new pharmacologically active tetra-oxo compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20180806 |