ES2058133T3 - Adn que codifica una imp-deshidrogenasa inactivada. - Google Patents

Adn que codifica una imp-deshidrogenasa inactivada.

Info

Publication number
ES2058133T3
ES2058133T3 ES87311199T ES87311199T ES2058133T3 ES 2058133 T3 ES2058133 T3 ES 2058133T3 ES 87311199 T ES87311199 T ES 87311199T ES 87311199 T ES87311199 T ES 87311199T ES 2058133 T3 ES2058133 T3 ES 2058133T3
Authority
ES
Spain
Prior art keywords
dna
imp
inosine
dehydrogenase
inactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87311199T
Other languages
English (en)
Inventor
Kenichiro Miyagawa
Hiroyuki Kimura
Yasuhiro Sumino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2058133T3 publication Critical patent/ES2058133T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN DNA, QUE ES ALTAMENTE HOMOLOGO AL DE UNA REGION DE GENE DE DESHIDROGENASA IMP Y/O SUS REGIONES LATERALES, Y DEVUELVE LA FUNCION DE DICHO GENE INACTIVADO, SE PUEDE PRODUCIR USANDO TECNICAS DE DNA RECOMBINANTE. DICHO DNA O UN VECTOR CON DICHO DNA SE UTILIZA PARA TRANSFORMAR UNA CEPA DE BACILLUS CAPAZ DE PRODUCIR POR LO MENOS UNA DE INOSINA, XANTOSINA Y GUANOSINA, Y LA INOSINA ASI OBTENIDA QUE PRODUCE LA CEPA ES ALTA EN ACUMULACION DE INOSINA Y ALTAMENTE ESTABLE.
ES87311199T 1986-12-26 1987-12-18 Adn que codifica una imp-deshidrogenasa inactivada. Expired - Lifetime ES2058133T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31158886 1986-12-26

Publications (1)

Publication Number Publication Date
ES2058133T3 true ES2058133T3 (es) 1994-11-01

Family

ID=18019045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87311199T Expired - Lifetime ES2058133T3 (es) 1986-12-26 1987-12-18 Adn que codifica una imp-deshidrogenasa inactivada.

Country Status (7)

Country Link
EP (1) EP0273660B1 (es)
JP (1) JPH01174385A (es)
KR (1) KR880007735A (es)
CN (1) CN1018846B (es)
AT (1) ATE92101T1 (es)
DE (1) DE3786771T2 (es)
ES (1) ES2058133T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393969A3 (en) * 1989-04-19 1991-03-13 Takeda Chemical Industries, Ltd. Dna containing imp dehydrogenase gene and its use
TW201793B (es) * 1989-08-04 1993-03-11 Takeda Pharm Industry Co Ltd
US5213972A (en) * 1989-12-08 1993-05-25 Chemgen Corporation Fermentation process for the production of pyrimidine deoxyribonucleosides
KR920002774A (ko) * 1990-07-03 1992-02-28 우메모또 요시마사 Dna 및 그의 용도
FR2665711B1 (fr) * 1990-08-08 1993-08-13 Centre Nat Rech Scient Integron de corynebacterie, procede de transformation d'une corynebacterie par ledit integron et corynebacterie obtenue.
JP4352716B2 (ja) * 2003-02-17 2009-10-28 味の素株式会社 バチルス属に属するイノシン生産菌及びイノシンの製造法
BRPI0509056A (pt) 2004-03-31 2007-08-21 Ajinomoto Kk bactéria pertencendo ao gênero bacillus ou ao gênero escherichia, e, métodos para produzir um nucleosìdeo de purina, para produzir um nucleotìdeo de purina e para produzir ácido 5'-guanìlico
US7326546B2 (en) 2005-03-10 2008-02-05 Ajinomoto Co., Inc. Purine-derived substance-producing bacterium and a method for producing purine-derived substance
WO2007125783A1 (ja) 2006-04-24 2007-11-08 Ajinomoto Co., Inc. プリン系物質生産菌及びプリン系物質の製造法
KR101250826B1 (ko) 2006-04-24 2013-04-11 아지노모토 가부시키가이샤 퓨린계 물질 생산균 및 퓨린계 물질의 제조법
RU2365622C2 (ru) 2006-12-22 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПРОДУКЦИИ ПУРИНОВЫХ НУКЛЕОЗИДОВ И НУКЛЕОТИДОВ МЕТОДОМ ФЕРМЕНТАЦИИ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Escherichia ИЛИ Bacillus
CN104745616B (zh) * 2015-04-17 2018-10-23 南京工业大学 一种肌苷酸脱氢酶基因缺陷型的节杆菌及其构建方法与应用
KR102556368B1 (ko) 2020-10-30 2023-07-18 세메스 주식회사 반송 핸드 및 기판 처리 장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074808A3 (en) * 1981-09-16 1984-07-04 University Patents, Inc. Recombinant method and materials
JPS59205983A (ja) * 1983-04-28 1984-11-21 ジエネツクス・コ−ポレイシヨン 異種遺伝子を原核微生物で発現させる方法
JPH0630583B2 (ja) * 1984-01-27 1994-04-27 武田薬品工業株式会社 Ｄνａおよびその用途
US4828994A (en) * 1984-09-21 1989-05-09 Genex Corporation Bacillus strains with reduced extracellular protease levels

Also Published As

Publication number Publication date
CN87101275A (zh) 1988-08-10
EP0273660B1 (en) 1993-07-28
EP0273660A2 (en) 1988-07-06
JPH01174385A (ja) 1989-07-10
DE3786771D1 (de) 1993-09-02
KR880007735A (ko) 1988-08-29
CN1018846B (zh) 1992-10-28
DE3786771T2 (de) 1993-11-11
ATE92101T1 (de) 1993-08-15
EP0273660A3 (en) 1989-04-19

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