ES2058196T3 - Derivados de azacromano. - Google Patents

Derivados de azacromano.

Info

Publication number
ES2058196T3
ES2058196T3 ES88114993T ES88114993T ES2058196T3 ES 2058196 T3 ES2058196 T3 ES 2058196T3 ES 88114993 T ES88114993 T ES 88114993T ES 88114993 T ES88114993 T ES 88114993T ES 2058196 T3 ES2058196 T3 ES 2058196T3
Authority
ES
Spain
Prior art keywords
derivatives
azacromano
azachroman
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88114993T
Other languages
English (en)
Inventor
Manfred Dr Baumgarth
Rolf Dr Gericke
Ingeborg Dr Lues
Peyer Jacques Dr De
Rolf Dr Bergmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2058196T3 publication Critical patent/ES2058196T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS AZACROMANOS DE FORMULA I, DONDE R1 A R5 TIENEN LA SIGNIFICACION CITADA EN LA SOLICITUD DE PATENTE 1, MUESTRAN EFECTOS SOBRE EL SISTEMA CARDIOVASCULAR.
ES88114993T 1987-09-24 1988-09-14 Derivados de azacromano. Expired - Lifetime ES2058196T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873732146 DE3732146A1 (de) 1987-09-24 1987-09-24 Azachromanderivate

Publications (1)

Publication Number Publication Date
ES2058196T3 true ES2058196T3 (es) 1994-11-01

Family

ID=6336753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88114993T Expired - Lifetime ES2058196T3 (es) 1987-09-24 1988-09-14 Derivados de azacromano.

Country Status (12)

Country Link
US (1) US4931454A (es)
EP (1) EP0308792B1 (es)
JP (1) JPH01102080A (es)
KR (1) KR890005113A (es)
AT (1) ATE92070T1 (es)
AU (1) AU623088B2 (es)
CA (1) CA1307532C (es)
DE (2) DE3732146A1 (es)
ES (1) ES2058196T3 (es)
HU (1) HU202532B (es)
IE (1) IE61295B1 (es)
ZA (1) ZA887158B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH674984A5 (es) * 1987-05-16 1990-08-15 Sandoz Ag
JPH03500542A (ja) * 1988-05-09 1991-02-07 ビーチャム　グループ　ピーエルシー 新規な化合物及び治療法
US5254557A (en) * 1988-05-09 1993-10-19 Beecham Group P.L.C. Compound and treatment
WO1991016888A1 (en) * 1990-04-23 1991-11-14 Rhone-Poulenc Rorer International (Holdings), Inc. Spiro[benzofurancycloalkane]carboxamides as 5ht3 antagonists
JP2009509928A (ja) 2005-09-01 2009-03-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ カリウムチャンネル開口剤としての新規ベンゾピラン誘導体
WO2007027780A2 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3682331D1 (de) * 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8613786D0 (en) * 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate

Also Published As

Publication number Publication date
EP0308792A3 (en) 1990-07-04
HU202532B (en) 1991-03-28
CA1307532C (en) 1992-09-15
US4931454A (en) 1990-06-05
KR890005113A (ko) 1989-05-11
DE3882629D1 (de) 1993-09-02
AU623088B2 (en) 1992-05-07
DE3732146A1 (de) 1989-04-06
JPH01102080A (ja) 1989-04-19
EP0308792A2 (de) 1989-03-29
AU2240388A (en) 1989-04-06
IE882897L (en) 1989-03-24
IE61295B1 (en) 1994-10-19
EP0308792B1 (de) 1993-07-28
ZA887158B (en) 1989-05-30
ATE92070T1 (de) 1993-08-15

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