ES2058651T3 - Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy. - Google Patents

Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy.

Info

Publication number
ES2058651T3
ES2058651T3 ES90106200T ES90106200T ES2058651T3 ES 2058651 T3 ES2058651 T3 ES 2058651T3 ES 90106200 T ES90106200 T ES 90106200T ES 90106200 T ES90106200 T ES 90106200T ES 2058651 T3 ES2058651 T3 ES 2058651T3
Authority
ES
Spain
Prior art keywords
manufacture
npy
medicine
guanidine derivatives
antagonist activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90106200T
Other languages
English (en)
Inventor
Martin C Dr Michel
Johann Peter Dr Dipl- Morsdorf
Heidrun Dr Engler
Helmut Dr Dipl-Ch Schickaneder
Kurt-Henning Dr Ahrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Application granted granted Critical
Publication of ES2058651T3 publication Critical patent/ES2058651T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION DESCRIBE LA APLICACION DE DERIVADOS DE GUANIDINA CON ESTRUCTURA PRINCIPAL DE FORMULA (I) PARA LA PRODUCCION DE MEDICAMENTOS CON ACCION ANTAGONISTICA NPY Y PARA LA OBTENCION DE MEDICAMENTOS PARA EL TRATAMIENTO DE LA ELEVADA PRESION SANGUINEA.
ES90106200T 1990-03-30 1990-03-30 Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy. Expired - Lifetime ES2058651T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90106200A EP0448765B1 (de) 1990-03-30 1990-03-30 Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung

Publications (1)

Publication Number Publication Date
ES2058651T3 true ES2058651T3 (es) 1994-11-01

Family

ID=8203843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90106200T Expired - Lifetime ES2058651T3 (es) 1990-03-30 1990-03-30 Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy.

Country Status (14)

Country Link
EP (1) EP0448765B1 (es)
JP (1) JPH0789939A (es)
KR (1) KR910016329A (es)
AT (1) ATE109979T1 (es)
AU (1) AU637882B2 (es)
CA (1) CA2037433A1 (es)
DE (1) DE59006842D1 (es)
DK (1) DK0448765T3 (es)
ES (1) ES2058651T3 (es)
HU (1) HU207945B (es)
IE (1) IE65252B1 (es)
IL (1) IL97424A (es)
PT (1) PT97138A (es)
ZA (1) ZA911471B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2126212A1 (en) * 1991-12-19 1993-07-08 Albert Tseng A novel molecule which inhibits neuropeptide tyrosine biological function
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) * 1994-02-03 1996-08-13 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5989920A (en) 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
AU7692896A (en) * 1995-12-01 1997-06-27 Novartis Ag Quinazolin-2,4-diazirines as NPY receptor antagonist
WO1997020823A2 (en) * 1995-12-01 1997-06-12 Novartis Ag 2-amino quinazoline derivatives as npy receptor antagonists
ZA974147B (en) * 1996-05-14 1997-11-14 Novo Nordisk As Somatostatin agonists and antagonists.
ES2176776T3 (es) * 1996-08-23 2002-12-01 Agouron Pharma Ligandos del neuropeptido-y.
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
WO1998018786A1 (en) * 1996-10-31 1998-05-07 Novo Nordisk A/S Constrained somatostatin agonists and antagonists
US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
AU6144098A (en) * 1997-02-14 1998-09-08 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
US6048900A (en) 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
JP2000510870A (ja) * 1997-02-14 2000-08-22 バイエル・コーポレーシヨン Ｎｐｙ５受容体アンタゴニストとしてのアミド類
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
US6121260A (en) 1997-07-03 2000-09-19 Neurogen Corporation Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives
ES2161594B1 (es) * 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AU2935200A (en) 1999-04-30 2000-11-17 Pfizer Products Inc. Compounds for the treatment of obesity
MXPA03002446A (es) 2000-09-20 2003-06-19 Schering Corp Imidazoles substituidos como agonistas o antagonistas duales h1 y h3 de histamina.
AU2001291040A1 (en) 2000-09-20 2002-04-02 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
ATE387439T1 (de) 2000-09-20 2008-03-15 Schering Corp Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten
DE60136284D1 (de) 2000-09-20 2008-12-04 Schering Corp Substituierte imidazole als histamine h1 und h3 agonisten oder antagonisten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3579000D1 (de) * 1985-04-02 1990-09-06 Heumann Pharma Gmbh & Co Imidazolylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DK0448765T3 (da) 1994-09-19
HU910979D0 (en) 1991-10-28
ZA911471B (en) 1991-11-27
IL97424A (en) 1995-05-26
PT97138A (pt) 1991-11-29
IE65252B1 (en) 1995-10-18
IL97424A0 (en) 1992-06-21
AU637882B2 (en) 1993-06-10
KR910016329A (ko) 1991-11-05
CA2037433A1 (en) 1991-10-01
EP0448765A1 (de) 1991-10-02
EP0448765B1 (de) 1994-08-17
HU207945B (en) 1993-07-28
JPH0789939A (ja) 1995-04-04
IE910995A1 (en) 1991-10-09
ATE109979T1 (de) 1994-09-15
HUT57044A (en) 1991-11-28
DE59006842D1 (de) 1994-09-22
AU7206891A (en) 1991-10-03

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