ES2058797T3 - Estabilizacion de compuestos organicos. - Google Patents
Estabilizacion de compuestos organicos.Info
- Publication number
- ES2058797T3 ES2058797T3 ES90304864T ES90304864T ES2058797T3 ES 2058797 T3 ES2058797 T3 ES 2058797T3 ES 90304864 T ES90304864 T ES 90304864T ES 90304864 T ES90304864 T ES 90304864T ES 2058797 T3 ES2058797 T3 ES 2058797T3
- Authority
- ES
- Spain
- Prior art keywords
- aliphatic
- halogen
- groups
- alkoxy
- cycloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 238000011105 stabilization Methods 0.000 title abstract 2
- 150000002894 organic compounds Chemical class 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- -1 aliphatic ester Chemical class 0.000 abstract 5
- 150000008431 aliphatic amides Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- GGOZGYRTNQBSSA-UHFFFAOYSA-N pyridine-2,3-diol Chemical compound OC1=CC=CN=C1O GGOZGYRTNQBSSA-UHFFFAOYSA-N 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 abstract 2
- LQUSVSANJKHVTM-UHFFFAOYSA-N 3-hydroxy-3h-pyridin-4-one Chemical compound OC1C=NC=CC1=O LQUSVSANJKHVTM-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZCUUVWCJGRQCMZ-UHFFFAOYSA-N 3-hydroxypyridin-4-one Natural products OC1=CC=NC=C1O ZCUUVWCJGRQCMZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE PRESENTA UNA MEZCLA DE UN PEPTIDO O UNA PROTEINA Y UNA HIDROXIPIRIDONA SIENDO: 1) UNA 3-HIDROXIPIRID-2-ONA O 3-HIDROXIPIRID-4-ONA EN LA CUAL EL ATOMO DE HIDROGENO UNIDO AL ATOMO DE NITROGENO SE REEMPLAZA MEDIANTE UN GRUPO AZIL HALIFATICO, POR UN GRUPO DE HIDROCARBONO HALIFATICO O POR UN GRUPO HIDROCARBONO HALIFATICO SUSTITUIDO POR UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE AZIL HALIFATICO, ALCOXIDO, CICLOALCOXIDO, AMIDO HALIFATICO, ESTER HALIFATICO, HALOGENO Y GRUPOS HIDROXIDOS Y, OPCIONALMENTE, EN EL CUAL UNO O MAS DE LOS ATOMOS DE HIDROGENO UNIDOS A LOS ATOMOS DE CARBONO DEL ANILLO SE REEMPLAZAN POR UN AZIL HALIFATICO, ALCOXIDO, CICLOALCOXIDO, AMIDO HALIFATICO, ESTER HALIFATICO, HALOGENO O GRUPO HIDROXIDO, POR UN GRUPO HIDROCARBONO HALIFTICO O POR UN GRUPO HIDRCARBONO HALIFATICO SUSTITUIDO POR ALCOXIDO, CICLOALCOXIDO, ESTER HALIFATICO, HALOGENO O UN GRUPO HIDROXIDO, O UNA SAL DE LOS MISMOS; 2) UNA 1-HIDROXIPIRID-2-ONA EN LA CUAL 1 O MAS DE LOS ATOMOS DE HIDROGENO UNIDOS A LOS ATOMOSDE CARBONO DEL ANILLO SE REEMPLAZAN POR UN SUSTITUYENTE SELECCIONADO ENTRE AZIL HALIFATICO, AMIDO HALIFATICO, CIANO, ESTER HALIFATICO, HALOGENO Y GRUPOS HIDROXIDO, ALCOXIDO Y GRUPOS CICLOALCOXIDOS Y ALCOXIDO Y GRUPOS CICLOALCOXIDOS SUSTITUIDOS POR UN ALCOXIDO, CICLOALCOXIDO, AMIDO HALIFATICO, ETER HALIFATICO, HALOGENO O GRUPO HIDROXIDO Y GRUPOS DE HIDROCARBONO HALIFATICO O GRUPOS DE HIDROCARBONO HALIFATICO SUSTITUIDOS POR UN ALCOXIDO, CICLOALCOXIDO, ESTER HALIFATICO, HALOGENO O GRUPO HIDROXIDO, PERO EXCLUYENDO LOS COMPUESTOS EN LOS CUALES DICHO REEMPLAZAMIENTOS DE ATOMOS DE HIDROGENO SE EFECTUA SOLAMENTE POR SUSTITUYENTES SELECCIONADOS ENTRE GRUPOS DE HIDROCARBONO HALIFATICO, GRUPOS HALOGENOS Y GRUPOS DE HIDROCABONO HALIFATICO SUSTITUIDOS POR UN GRUPO HALOGENO O UNA SAL DEL MISMO; 3) UN COMPUESTO EN EL CUAL DOS O MAS ANILLOS QUE SE SELECCIONAN ENTRE 3-HIDROXIPIRID-2-ONAS, 3-HIDROXIPIRID-4-ONAS Y 1-HIDROXIPIRID-2-ONAS, ESTAN UNIDOS COVALENTEMENTE CON LOS ANILLOS QUE RETIENEN SUS GRUPOS OXOS E HIDROXIDO ADYACENTES; ESTOS COMPUESTOS TIENEN VALOR EN EL EFECTO DE ESTABILIZACION DEL PEPTIDO O LA PROTEINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898910521A GB8910521D0 (en) | 1989-05-08 | 1989-05-08 | The stabilization of organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2058797T3 true ES2058797T3 (es) | 1994-11-01 |
Family
ID=10656387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90304864T Expired - Lifetime ES2058797T3 (es) | 1989-05-08 | 1990-05-04 | Estabilizacion de compuestos organicos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5185319A (es) |
| EP (1) | EP0397409B1 (es) |
| JP (1) | JPH0320298A (es) |
| AT (1) | ATE91631T1 (es) |
| CA (1) | CA2016165A1 (es) |
| DE (1) | DE69002275T2 (es) |
| DK (1) | DK0397409T3 (es) |
| ES (1) | ES2058797T3 (es) |
| GB (2) | GB8910521D0 (es) |
| PT (1) | PT93974A (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541116A (en) * | 1991-09-30 | 1996-07-30 | B.R.A.H.M.S. Diagnostica Gmbh | Method for the stabilization of endogenous, physiologically active peptides |
| GB9209078D0 (en) * | 1992-04-27 | 1992-06-10 | Hider Robert C | Pharmaceutical compositions |
| GB9217099D0 (en) * | 1992-08-12 | 1992-09-23 | British Tech Group | Pharmaceutical compositions |
| US6294152B1 (en) * | 1999-01-11 | 2001-09-25 | The University Of Toledo | Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging |
| WO2005014034A1 (en) * | 2003-07-14 | 2005-02-17 | Nps Allelix Corp. | Stabilized formulation of parathyroid hormone |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783441A (en) * | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
| JPS5822200A (ja) * | 1981-08-04 | 1983-02-09 | テイボ−株式会社 | 極細マ−キングペンのペン先突出量調節機構 |
| GR78491B (es) * | 1982-03-24 | 1984-09-27 | Nat Res Dev | |
| JPS58222007A (ja) * | 1982-06-16 | 1983-12-23 | Lion Corp | 皮膚用化粧料 |
| JPS59710A (ja) * | 1982-06-25 | 1984-01-05 | Matsushita Electric Ind Co Ltd | 表示器の制御装置 |
| GB8308054D0 (en) * | 1983-03-24 | 1983-05-05 | Hider R C | Pharmaceutical compositions |
| GB8325496D0 (en) * | 1983-09-23 | 1983-10-26 | Hider R C | Pharmaceutical compositions |
| GB8325494D0 (en) * | 1983-09-23 | 1983-10-26 | Hider R C | Pharmaceutical compositions |
| US4698431A (en) * | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
-
1989
- 1989-05-08 GB GB898910521A patent/GB8910521D0/en active Pending
-
1990
- 1990-05-03 US US07/520,203 patent/US5185319A/en not_active Expired - Fee Related
- 1990-05-04 DE DE90304864T patent/DE69002275T2/de not_active Expired - Fee Related
- 1990-05-04 GB GB9010086A patent/GB2231331A/en not_active Withdrawn
- 1990-05-04 DK DK90304864.3T patent/DK0397409T3/da active
- 1990-05-04 AT AT90304864T patent/ATE91631T1/de not_active IP Right Cessation
- 1990-05-04 EP EP90304864A patent/EP0397409B1/en not_active Expired - Lifetime
- 1990-05-04 ES ES90304864T patent/ES2058797T3/es not_active Expired - Lifetime
- 1990-05-07 CA CA002016165A patent/CA2016165A1/en not_active Abandoned
- 1990-05-07 PT PT93974A patent/PT93974A/pt not_active Application Discontinuation
- 1990-05-08 JP JP2118525A patent/JPH0320298A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT93974A (pt) | 1991-01-08 |
| EP0397409A1 (en) | 1990-11-14 |
| DE69002275D1 (de) | 1993-08-26 |
| CA2016165A1 (en) | 1990-11-08 |
| DE69002275T2 (de) | 1993-11-04 |
| US5185319A (en) | 1993-02-09 |
| GB9010086D0 (en) | 1990-06-27 |
| DK0397409T3 (da) | 1993-08-30 |
| GB8910521D0 (en) | 1989-06-21 |
| ATE91631T1 (de) | 1993-08-15 |
| JPH0320298A (ja) | 1991-01-29 |
| GB2231331A (en) | 1990-11-14 |
| EP0397409B1 (en) | 1993-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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