ES2059388T3 - N-(2-(4-carboximetoxifenil)-1-metiletil)-2-hidroxi-2-(3-clorofenil)etanamina, el ester metilico, la sal y los estereoisomeros de los mismos. - Google Patents

N-(2-(4-carboximetoxifenil)-1-metiletil)-2-hidroxi-2-(3-clorofenil)etanamina, el ester metilico, la sal y los estereoisomeros de los mismos.

Info

Publication number
ES2059388T3
ES2059388T3 ES87307446T ES87307446T ES2059388T3 ES 2059388 T3 ES2059388 T3 ES 2059388T3 ES 87307446 T ES87307446 T ES 87307446T ES 87307446 T ES87307446 T ES 87307446T ES 2059388 T3 ES2059388 T3 ES 2059388T3
Authority
ES
Spain
Prior art keywords
carboximetoxifenil
methylethyl
chlorophenyl
salt
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87307446T
Other languages
English (en)
Inventor
Anthony Trevor Ainsworth
David Glynn Smith
Jonathan Robert Sanders Arch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2059388T3 publication Critical patent/ES2059388T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

N-[2-(4-CARBOXIMETOXIFENIL)-1-(R)-1-METILETIL]-2(R)-2-HIDROXI-2-(3-CLOROFENIL) ETANOAMINA E EL ESTER METIL DEL MISMO O UNA SAL DEL MISMO FARMACEUTICAMENTE ACEPTABLE, (EL ISOMERO RR''-), OPCIONALMENTE MEZCLADO CON N-[2-(CARBOXIMETOXIFENIL)-1-METILETIL]-2-HIDROXI-2- (3-CLOROFENIL) ETANOAMINA, O EL ESTER METIL DEL MISMO, O UNA SAL DEL MISMO FARMACEUTICAMENTE ACEPTABLE (O EL ISOMERO SS-), EN DONDE EL ISOMERO SS- FORMA MENOS DEL 50% POR PESO DE LA MEZCLA DE LOS ISOMEROS RR- Y SS-; UN PROCESO PARA LA PREPARACION DE TALES COMPUESTOS, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS Y EL USO DE TALES COMPUESTOS Y COMPOSICIONES EN MEDICINA Y AGRICULTURA.
ES87307446T 1986-08-29 1987-08-24 N-(2-(4-carboximetoxifenil)-1-metiletil)-2-hidroxi-2-(3-clorofenil)etanamina, el ester metilico, la sal y los estereoisomeros de los mismos. Expired - Lifetime ES2059388T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868620951A GB8620951D0 (en) 1986-08-29 1986-08-29 Compounds

Publications (1)

Publication Number Publication Date
ES2059388T3 true ES2059388T3 (es) 1994-11-16

Family

ID=10603408

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87307446T Expired - Lifetime ES2059388T3 (es) 1986-08-29 1987-08-24 N-(2-(4-carboximetoxifenil)-1-metiletil)-2-hidroxi-2-(3-clorofenil)etanamina, el ester metilico, la sal y los estereoisomeros de los mismos.

Country Status (12)

Country Link
EP (1) EP0262785B1 (es)
JP (1) JPS6379857A (es)
AU (1) AU608238B2 (es)
CA (1) CA1332741C (es)
DE (1) DE3787860T2 (es)
DK (1) DK448587A (es)
ES (1) ES2059388T3 (es)
GB (1) GB8620951D0 (es)
IE (1) IE63546B1 (es)
NZ (1) NZ221596A (es)
PT (1) PT85608B (es)
ZA (1) ZA876441B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
GB9215844D0 (en) * 1992-07-25 1992-09-09 Smithkline Beecham Plc Novel compounds
GB9308178D0 (en) * 1993-04-21 1993-06-02 Smithkline Beecham Plc Novel compounds
WO1994025427A1 (en) * 1993-04-26 1994-11-10 Fujisawa Pharmaceutical Co., Ltd. Ethanolamine derivatives useful for the treatment of gastrointestinal disorders
AU7532294A (en) * 1993-07-31 1995-02-28 Smithkline Beecham Plc 2-benzoheterocyclyloxy or thiopropanolamine derivatives with adreno receptor agonist activity
JPH09502193A (ja) * 1993-09-09 1997-03-04 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 抗高血糖症および／または抗肥満症活性を有するホスフィン酸誘導体
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
CA2286913C (en) 1997-04-30 2008-12-09 Bridge Pharma, Inc. Composition and methods using an eutomer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3061334D1 (en) * 1979-06-16 1983-01-20 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
DE3267406D1 (en) * 1981-07-11 1985-12-19 Beecham Group Plc Secondary phenyl ethanol amines and their pharmaceutical use
ZA824903B (en) * 1981-07-11 1983-04-27 Beecham Group Plc Secondary amines
GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
DK448587D0 (da) 1987-08-27
AU7760887A (en) 1988-03-03
AU608238B2 (en) 1991-03-28
PT85608A (pt) 1988-08-17
DE3787860D1 (de) 1993-11-25
PT85608B (pt) 1994-08-31
DE3787860T2 (de) 1994-02-10
ZA876441B (en) 1988-08-31
EP0262785B1 (en) 1993-10-20
CA1332741C (en) 1994-10-25
IE63546B1 (en) 1995-05-17
IE872299L (en) 1988-02-29
DK448587A (da) 1988-03-01
NZ221596A (en) 1990-02-26
JPS6379857A (ja) 1988-04-09
GB8620951D0 (en) 1986-10-08
EP0262785A1 (en) 1988-04-06

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