ES2060646T3 - Virus rna hibrido. - Google Patents

Virus rna hibrido.

Info

Publication number
ES2060646T3
ES2060646T3 ES88300908T ES88300908T ES2060646T3 ES 2060646 T3 ES2060646 T3 ES 2060646T3 ES 88300908 T ES88300908 T ES 88300908T ES 88300908 T ES88300908 T ES 88300908T ES 2060646 T3 ES2060646 T3 ES 2060646T3
Authority
ES
Spain
Prior art keywords
viruses
recombinant
rna
rna viruses
hybrid rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88300908T
Other languages
English (en)
Inventor
Paul G Ahlquist
Roy D French
Robert F Sacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mycogen Plant Science Inc
Original Assignee
Lubrizol Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lubrizol Genetics Inc filed Critical Lubrizol Genetics Inc
Application granted granted Critical
Publication of ES2060646T3 publication Critical patent/ES2060646T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/00023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/14011—Bromoviridae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONA UN VIRUS RNA RECOMBINANTE PERMITIENDO LA ENCAPSIDACION DE SECUENCIAS VIRALES POR INGENIERIA GENETICA EN CAPSIDOS PROTEINICOS HETEROLOGOS, CAPAS PREFERIBLEMENTE EN FORMA DE VARILLA. PUESTO QUE LOS VIRUS ICOSAHEDROS ESTAN LIMITADOS EN LA CANTIDAD DE RNA QUE PUEDEN LLEVAR Y LOS VIRUS EN FORMA DE VARILLA SON EXPANSIBLES, ESTA INVENCION HACE POSIBLE QUE SE AUMENTE (O DISMINUYA) EL TAMAÑO DE LOS COMPONENTES RNA DEL VIRUS RECOMBINANTES. TAMBIEN SE PROPORCIONAN METODOS PARA OBTENER Y USAR TALES VIRUS RECOMBINANTES, ESPECIALMENTE RESPECTO A LA TRANFECCION DE PLANTAS PARA PROVOCAR CAMBIOS GENOTIPICOS Y FENOTIPICOS.
ES88300908T 1987-02-09 1988-02-03 Virus rna hibrido. Expired - Lifetime ES2060646T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1225387A 1987-02-09 1987-02-09

Publications (1)

Publication Number Publication Date
ES2060646T3 true ES2060646T3 (es) 1994-12-01

Family

ID=21754067

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88300908T Expired - Lifetime ES2060646T3 (es) 1987-02-09 1988-02-03 Virus rna hibrido.

Country Status (8)

Country Link
US (3) US5602242A (es)
EP (1) EP0278667B1 (es)
JP (2) JP3479531B2 (es)
AT (1) ATE108828T1 (es)
AU (1) AU606382B2 (es)
CA (1) CA1337933C (es)
DE (1) DE3850683T2 (es)
ES (1) ES2060646T3 (es)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE108828T1 (de) * 1987-02-09 1994-08-15 Lubrizol Genetics Inc Hybrides rns-virus.
ES2165345T3 (es) * 1987-07-10 2002-03-16 Syngenta Participations Ag Resistencia virica inducible en plantas.
US7033835B1 (en) 1988-02-26 2006-04-25 Large Scale Biology Corporation Production of peptides in plants as viral coat protein fusions
US6054566A (en) 1988-02-26 2000-04-25 Biosource Technologies, Inc. Recombinant animal viral nucleic acids
US5977438A (en) * 1988-02-26 1999-11-02 Biosource Technologies, Inc. Production of peptides in plants as viral coat protein fusions
US5316931A (en) * 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US6660500B2 (en) 1988-02-26 2003-12-09 Large Scale Biology Corporation Production of peptides in plants as viral coat protein fusions
US6284492B1 (en) 1988-02-26 2001-09-04 Large Scale Biology Corporation Recombinant animal viral nucleic acids
DE3829524A1 (de) * 1988-08-31 1990-03-01 Behringwerke Ag Verwendung von transglutaminasen als immunsuppressiva
WO1990012107A1 (en) * 1989-03-31 1990-10-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Recombinant expression system based on satellite tobacco mosaic virus
GB9108386D0 (en) 1991-04-19 1991-06-05 Agricultural Genetics Co Modified plant viruses as vectors
EP0596979B1 (en) * 1991-08-01 2002-01-30 Large Scale Biology Corporation Recombinant plant viral nucleic acids
EP0573767B1 (en) * 1992-04-28 2000-07-12 Nihon Nohyaku Co., Ltd. Process for production of exogenous gene or its product in plant cells
AU4259193A (en) * 1992-04-28 1993-11-29 Frank Andreas Harald Meyer Medicament for the gene-therapeutic treatment of human beings, animals and plants, especially to block virus multiplication and carcinogenes and process for producing the medicament
ES2194865T3 (es) 1992-12-30 2003-12-01 Biosource Genetics Corp Amplificacion viral de arn mensajero recombinante en plantas transgenicas.
US5491076A (en) * 1993-11-01 1996-02-13 The Texas A&M University System Expression of foreign genes using a replicating polyprotein producing virus vector
US5939262A (en) * 1996-07-03 1999-08-17 Ambion, Inc. Ribonuclease resistant RNA preparation and utilization
US5677124A (en) * 1996-07-03 1997-10-14 Ambion, Inc. Ribonuclease resistant viral RNA standards
US5869287A (en) * 1996-07-12 1999-02-09 Wisconsin Alumni Research Foundation Method of producing particles containing nucleic acid sequences in yeast
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US6468745B1 (en) 1998-01-16 2002-10-22 Large Scale Biology Corporation Method for expressing a library of nucleic acid sequence variants and selecting desired traits
US20030027173A1 (en) * 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US20030166169A1 (en) * 1998-01-16 2003-09-04 Padgett Hal S. Method for constructing viral nucleic acids in a cell-free manner
US20030077619A1 (en) * 1998-01-16 2003-04-24 Kumagai Monto H. Method of isolating human cDNAs by transfecting a nucleic acid sequence of a non-plant donor into a host plant in an anti-sense orientation
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
US6037456A (en) 1998-03-10 2000-03-14 Biosource Technologies, Inc. Process for isolating and purifying viruses, soluble proteins and peptides from plant sources
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
WO1999049029A1 (en) * 1998-03-20 1999-09-30 Benitec Australia Ltd Control of gene expression
WO2000009725A2 (en) * 1998-08-11 2000-02-24 Biosource Technologies, Inc. Method for recovering proteins from the interstitial fluid of plant tissues
US7148400B1 (en) * 1999-04-20 2006-12-12 Bayer Bioscience N.V. Methods and means for delivering inhibitory RNA to plants and applications thereof
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
WO2001053323A2 (en) 2000-01-24 2001-07-26 Ramot University Authority For Applied Research & Industrial Development Ltd. Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby
US20020061309A1 (en) * 2000-03-08 2002-05-23 Garger Stephen J. Production of peptides in plants as N-terminal viral coat protein fusions
DE60142475D1 (de) 2000-03-27 2010-08-12 Technion Res And Dev Of Founda Einkettige haupthistokompatibilitätskomplexe der klasse i (mhc-i), kodierende konstrukte und methoden ihrer erzeugung
AU2001263096A1 (en) * 2000-05-24 2001-12-03 Yu Feng Compositions and methods for production of rna viruses and rna virus-based vector particles
US6800748B2 (en) 2001-01-25 2004-10-05 Large Scale Biology Corporation Cytoplasmic inhibition of gene expression and expression of a foreign protein in a monocot plant by a plant viral vector
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
US6776751B2 (en) * 2002-04-22 2004-08-17 Kendor Laboratory Products, Lp Rotor cover attachment apparatus
AU2003284388A1 (en) * 2002-11-01 2004-06-07 New England Biolabs, Inc. Organellar targeting of rna and its use in the interruption of environmental gene flow
WO2004044161A2 (en) * 2002-11-06 2004-05-27 Fraunhofer Usa Expression of foreign sequences in plants using trans-activation system
US7683238B2 (en) 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
US7692063B2 (en) * 2002-11-12 2010-04-06 Ibio, Inc. Production of foreign nucleic acids and polypeptides in sprout systems
EP1594956A4 (en) * 2003-02-03 2007-08-01 Fraunhofer Usa Inc SYSTEM FOR EXPRESSION OF GENES IN PLANTS
AU2005234725B2 (en) 2003-05-22 2012-02-23 Evogene Ltd. Methods of Increasing Abiotic Stress Tolerance and/or Biomass in Plants and Plants Generated Thereby
CA2978152C (en) 2003-05-22 2021-01-26 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
AU2005216133A1 (en) * 2004-02-20 2005-09-09 Fraunhofer Usa, Inc. Systems and methods for clonal expression in plants
CA2570195C (en) 2004-06-14 2017-10-24 Evogene Ltd. Polynucleotides and polypeptides involved in plant fiber development and methods of using same
US8962915B2 (en) 2004-06-14 2015-02-24 Evogene Ltd. Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same
DE602005023332D1 (de) 2004-09-29 2010-10-14 Collplant Ltd Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung
US20060288449A1 (en) * 2004-10-12 2006-12-21 Garger Stephen J Process for purifying target compounds from plant sources using ceramic filtration
FR2878532B1 (fr) * 2004-11-26 2007-03-02 Genoplante Valor Soc Par Actio Methode d'adressage d'acides nucleiques vers des plastes
BRPI0616012A2 (pt) 2005-07-18 2011-05-31 Protalix Ltd administração via mucosa ou intestino de macromoléculas biologicamente ativas
EP1909829A4 (en) * 2005-07-19 2009-11-11 Dow Global Technologies Inc RECOMBINANT GRIP VACCINES
WO2007117264A2 (en) 2005-08-03 2007-10-18 Fraunhofer Usa, Inc. Compositions and methods for production of immunoglobulins
WO2008048344A2 (en) * 2006-02-13 2008-04-24 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
US7993655B2 (en) 2006-04-21 2011-08-09 Dow Agrosciences Llc Vaccine for avian influenza and methods of use
EP2046109A4 (en) 2006-07-20 2010-01-06 Yeda Res & Dev PHOTOSYNTHETIC ORGANISMS, COMPOSITIONS AND METHODS FOR GENERATING THESE ORGANISMS
EP2096909A4 (en) 2006-12-20 2010-08-04 Evogene Ltd POLYNUCLEOTIDES AND POLYPEPTIDES INVOLVED IN THE DEVELOPMENT OF VEGETABLE FIBERS AND METHODS OF USE
CN101854798B (zh) 2007-04-09 2013-04-03 伊沃基因有限公司 用于增加植物的油含量、生长速率和/或产量的多核苷酸、多肽和方法
WO2009014782A2 (en) * 2007-04-27 2009-01-29 Dow Global Technologies Inc. Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles
EP2178558B1 (en) 2007-07-11 2014-04-30 iBio, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
AU2008278654B2 (en) 2007-07-24 2014-06-05 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same
JP2011504374A (ja) 2007-11-26 2011-02-10 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド 繊維状ポリペプチドおよび多糖を含む組成物
EP2240510B1 (en) 2007-12-27 2017-05-10 Evogene Ltd. Isolated polypeptides, polynucleotides useful for modifying salinity stress tolerance in plants
US9095569B2 (en) 2008-04-18 2015-08-04 Collplant Ltd. Methods of generating and using procollagen
US8791324B2 (en) 2008-04-21 2014-07-29 Danziger Innovations Ltd. Plant viral expression vectors and use of same for generating genotypic variations in plant genomes
WO2010020941A2 (en) 2008-08-18 2010-02-25 Evogene Ltd. Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants
MX2011003575A (es) 2008-10-30 2011-04-21 Evogene Ltd Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para aumentar el rendimiento de la planta, biomasa, tasa de crecimiento, vigor, contenido de aceite, tolerancia al estres abiotico de las plantas y eficacia en el uso de nitrogeno.
EP2373792B1 (en) 2008-12-29 2016-11-02 Evogene Ltd. Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same
LT3460062T (lt) 2009-03-02 2021-06-25 Evogene Ltd. Izoliuoti polinukleotidai ir polipeptidai, ir jų naudojimo būdai, skirti augalų derlingumui didinti ir (arba) žemės ūkio savybėms gerinti
MX381662B (es) 2009-06-10 2025-03-13 Evogene Ltd Polinucleotidos y polipeptidos aislados, y metodos para utilizarlos para mejorar la eficacia en el uso de nitrogeno, rendimiento, tasa de crecimiento, vigor, biomasa, contenido de aceite y/o tolerancia al estres abiotico.
WO2011048600A1 (en) 2009-10-21 2011-04-28 Danziger Innovations Ltd. Generating genotypic variations in plant genomes by gamete infection
WO2011067745A2 (en) 2009-12-06 2011-06-09 Rosetta Green Ltd. Compositions and methods for enhancing plants resistance to abiotic stress
BR112012016033B1 (pt) 2009-12-28 2021-03-09 Evogene Ltd. métodos de aumento de produção de semente, biomassa, taxa de crescimento, vigor, tolerância à deficiência de nitrogênio, eficiência no uso de nitrogênio e/ou redução do tempo de florescimento de uma planta, e, para produzir uma planta transgênica
US9328353B2 (en) 2010-04-28 2016-05-03 Evogene Ltd. Isolated polynucleotides and polypeptides for increasing plant yield and/or agricultural characteristics
US20130097731A1 (en) 2010-06-16 2013-04-18 Futuragene Israel Ltd. Pest-resistant plants containing a combination of a spider toxin and a chitinase
EP2593468B1 (en) 2010-07-12 2020-06-10 The State of Israel, Ministry of Agriculture and Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Isolated polynucleotides and methods and plants using same for regulating plant acidity
EP2593554A2 (en) 2010-07-15 2013-05-22 Technion Research And Development Foundation Ltd. Nucleic acid construct for increasing abiotic stress tolerance in plants
WO2012032520A1 (en) 2010-09-07 2012-03-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease
BR112013010825A2 (pt) 2010-11-03 2019-09-24 Futuragene Israel Ltda plantas transgênicas com rendimentos melhorados de sacarificação e métodos para geração das mesmas
CN103443270B (zh) 2011-01-20 2017-06-06 普罗塔里克斯有限公司 用于在植物和植物细胞中表达α‑半乳糖苷酶的核酸构建体
CN106978437A (zh) 2011-03-02 2017-07-25 富途锐基尼以色列有限公司 具有功能失调的t3ss蛋白的抗菌性转基因植物
WO2012156976A1 (en) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of producing artemisinin in non-host plants and vectors for use in same
UA116097C2 (uk) 2011-12-11 2018-02-12 Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре Спосіб модуляції провідності устячка рослини
US9603907B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Dry powder formulations of dNase I
WO2013121405A1 (en) 2012-02-19 2013-08-22 Protalix Ltd. Oral unit dosage forms and uses of same for the treatment of gaucher disease
WO2014033723A1 (en) 2012-09-03 2014-03-06 A.B. Seeds Ltd. Method of improving abiotic stress tolerance of plants and plants generated thereby
CA2902727C (en) 2013-03-06 2020-08-18 Protalix Ltd. Use of plant cells expressing a tnfalpha polypeptide inhibitor in therapy
US20160017020A1 (en) 2013-03-06 2016-01-21 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
WO2015118547A1 (en) 2014-02-10 2015-08-13 Protalix Ltd. Method of maintaining disease stability in a subject having gaucher's disease
CA2972739A1 (en) 2014-09-11 2016-03-17 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of producing mogrosides and compositions comprising same and uses thereof
WO2016079739A2 (en) 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
EP3224363B1 (en) 2014-11-27 2021-11-03 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Nucleic acid constructs for genome editing
CN109068605B (zh) 2016-01-21 2022-11-11 以色列国家农业和农村发展农业研究组织沃尔坎尼中心 单性结实植物及其产生方法
EP3630973A1 (en) 2017-05-31 2020-04-08 Tropic Biosciences UK Limited Methods of selecting cells comprising genome editing events
GB201708665D0 (en) 2017-05-31 2017-07-12 Tropic Biosciences Uk Ltd Compositions and methods for increasing extractability of solids from coffee beans
GB201708662D0 (en) 2017-05-31 2017-07-12 Tropic Biosciences Uk Ltd Compositions and methods for increasing shelf-life of banana
WO2018224861A1 (en) 2017-06-07 2018-12-13 International Rice Research Institute Increasing hybrid seed production through higher outcrossing rate in cytoplasmic male sterile gramineae plants and related materials and methods
IL273245B2 (en) 2017-09-15 2025-03-01 Commw Scient Ind Res Org RNA molecules
US20200270604A1 (en) 2017-09-19 2020-08-27 Tropic Biosciences UK Limited Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells
EP3707641A2 (en) 2017-12-03 2020-09-16 Seedx Technologies Inc. Systems and methods for sorting of seeds
EP3707642A1 (en) 2017-12-03 2020-09-16 Seedx Technologies Inc. Systems and methods for sorting of seeds
US11504748B2 (en) 2017-12-03 2022-11-22 Seedx Technologies Inc. Systems and methods for sorting of seeds
GB201807192D0 (en) 2018-05-01 2018-06-13 Tropic Biosciences Uk Ltd Compositions and methods for reducing caffeine content in coffee beans
EP3787702B1 (en) 2018-05-03 2024-08-07 CollPlant Ltd. Dermal fillers and applications thereof
EP3802839A1 (en) 2018-06-07 2021-04-14 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Nucleic acid constructs and methods of using same
EP3800998A1 (en) 2018-06-07 2021-04-14 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Methods of regenerating and transforming cannabis
WO2020008412A1 (en) 2018-07-04 2020-01-09 Ukko Inc. Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease
GB201903520D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
GB201903519D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
GB201903521D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd No title
KR20220042139A (ko) 2019-07-04 2022-04-04 유코 아이엔씨. 에피토프 제거된 알파 글리아딘 및 복강병 및 글루텐 민감성의 관리를 위한 이의 용도
US20220298522A1 (en) 2019-07-30 2022-09-22 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
US12385054B2 (en) 2019-11-19 2025-08-12 Protalix Ltd. Removal of constructs from transformed cells
WO2021202513A1 (en) 2020-03-31 2021-10-07 Elo Life Systems Modulation of endogenous mogroside pathway genes in watermelon and other cucurbits
US20230309480A1 (en) 2020-08-18 2023-10-05 International Rice Research Institute Methods of increasing outcrossing rates in gramineae
EP4225902A1 (en) 2020-10-05 2023-08-16 Protalix Ltd. Dicer-like knock-out plant cells
US20240060079A1 (en) 2020-10-23 2024-02-22 Elo Life Systems Methods for producing vanilla plants with improved flavor and agronomic production
AU2021387979A1 (en) 2020-11-26 2023-03-30 Ukko Inc. Modified high molecular weight glutenin subunit and uses thereof
WO2022226316A1 (en) 2021-04-22 2022-10-27 Precision Biosciences, Inc. Compositions and methods for generating male sterile plants

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1192510A (en) * 1981-05-27 1985-08-27 Lawrence E. Pelcher Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom
CA1288073C (en) * 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
US6608241B1 (en) * 1985-10-29 2003-08-19 Monsanto Technology Llc Protection of plants against viral infection
JPS62147822A (ja) * 1985-12-23 1987-07-01 Nec Corp 時分割多元接続通信装置
GB8601680D0 (en) * 1986-01-23 1986-02-26 Agricultural Genetics Co Modification of plant viruses
ATE108828T1 (de) * 1987-02-09 1994-08-15 Lubrizol Genetics Inc Hybrides rns-virus.

Also Published As

Publication number Publication date
JP2004000260A (ja) 2004-01-08
US5602242A (en) 1997-02-11
DE3850683T2 (de) 1994-10-27
AU606382B2 (en) 1991-02-07
JP3479531B2 (ja) 2003-12-15
EP0278667A3 (en) 1990-09-05
US5804439A (en) 1998-09-08
EP0278667A2 (en) 1988-08-17
ATE108828T1 (de) 1994-08-15
AU1138388A (en) 1988-08-11
DE3850683D1 (de) 1994-08-25
CA1337933C (en) 1996-01-16
US5627060A (en) 1997-05-06
JPS63301787A (ja) 1988-12-08
EP0278667B1 (en) 1994-07-20

Similar Documents

Publication Publication Date Title
ES2060646T3 (es) Virus rna hibrido.
PT787200E (pt) Adenovirus melhorado e metodos para a sua utilizacao
ES2169754T3 (es) Peptidos de conotoxina.
ES2054878T3 (es) Expresion de la proapolipoproteina a-i humana.
ES2156958T3 (es) Virus hibrido adenovirus-aav y metodo de utilizacion del mismo.
ES2061500T3 (es) Diagnosis y vacunas de la hepatitis delta su preparacion y uso.
ES2012739T3 (es) Diagnosticos y vacunas para nanbv.
DK271386D0 (da) Kompakt armeret struktur
ES8500322A1 (es) Un metodo de modificar un virus para conferirle una nueva funcion biologica.
ES2170622B1 (es) Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
AR025146A1 (es) UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA.
ES2115662T3 (es) Modificacion genetica de celulas endoteliales.
AR052206A2 (es) Reforzador para un promotor de genes, metodo para activar o incrementar la expresion de un promotor de genes, secuencia de adn quimerico,plantas celulas y propagulos que comprenden dichos reforzadores
DK366483D0 (da) Gen, dna-transfervektor eller underenhed heraf, der koder for human preprorelaxin eller en underenhed deraf, fremgangsmade til fremstilling af samme samt fremgangsmade til fremstilling af human preprorelaxin eller en underenhed deraf
AR004341A1 (es) Vacunas contra tumores y procedimiento para su produccion.
ES2055922T3 (es) Vacunas para la proteccion ante infecciones por virus hiv, procedimiento para su preparacion y su uso como agente de diagnostico e inmunoterapeutico.
ES2134197T3 (es) Vacunas contra el virus del herpes simplex vp16.
ES2069742T3 (es) Proteina de la capsida del calicivirus felino y secuencia nucleotida.
ES8307298A1 (es) "un metodo para producir una molecula de acido desoxi-ribonucleico recombinante".
ES2131050T3 (es) Genes de resistencia a virus/herbicidas, procedimiento para su preparacion y su uso.
DE69110897D1 (de) Hemmung der viralen replikation.
ES2093606T3 (es) Gen del receptor de celulas t localizado en el locus alfa y estructuras artificiales de adn.
ES2054230T3 (es) Un proceso para la preparacion de un enterovirus o rinovirus atenuado.
ES2085163T3 (es) Vacunas contra los parasitos metazoos.
ES2174604T3 (es) Utilizacion de interferon alfa 5 en el tratamiento de las hepatopatias de origen viral.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 278667

Country of ref document: ES