ES2061720T3 - Transformacion de tejido vegetal. - Google Patents
Transformacion de tejido vegetal.Info
- Publication number
- ES2061720T3 ES2061720T3 ES88810280T ES88810280T ES2061720T3 ES 2061720 T3 ES2061720 T3 ES 2061720T3 ES 88810280 T ES88810280 T ES 88810280T ES 88810280 T ES88810280 T ES 88810280T ES 2061720 T3 ES2061720 T3 ES 2061720T3
- Authority
- ES
- Spain
- Prior art keywords
- transformation
- plant tissue
- vegetable material
- corn
- involves
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000009466 transformation Effects 0.000 title abstract 3
- 239000000463 material Substances 0.000 abstract 2
- 239000005418 vegetable material Substances 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
- Fertilizers (AREA)
- Hydroponics (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Cultivation Of Plants (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
LA INVENCION PROPORCIONA UN METODO PARA TRANSFORMAR MATERIAL VEGETAL QUE IMPLICA PONER EN CONTACTO EL MATERIAL CON UNA SOLUCION DE TRANSFORMACION QUE CONTIENE ADN Y UN AGENTE DE PERMEACION DE MEMBRANA, EN PRESENCIA DE UNA CORRIENTE ELECTRICA DUTRANTE UN TIEMPO SUFICIENTE PARA QUE SE REALICE LA TRANSFORMACION. TAMBIEN SE REFIERE LA INVENCION AL MATERIAL VEGETAL Y A LAS PLANTAS FERTILES ASI OBTENIDOS, ASI COMO A NUEVO MATERIAL VEGETAL TRANSFORMADO, EN PARTICULAR DE MAIZ.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2771287A | 1987-05-05 | 1987-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2061720T3 true ES2061720T3 (es) | 1994-12-16 |
Family
ID=21839344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88810280T Expired - Lifetime ES2061720T3 (es) | 1987-05-05 | 1988-05-03 | Transformacion de tejido vegetal. |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0574356A1 (es) |
| JP (1) | JPS63301792A (es) |
| KR (1) | KR880014104A (es) |
| CN (1) | CN1030442A (es) |
| AT (1) | ATE100858T1 (es) |
| AU (1) | AU615905B2 (es) |
| BR (1) | BR8802175A (es) |
| CA (1) | CA1328236C (es) |
| DE (1) | DE3887375T2 (es) |
| DK (1) | DK240088A (es) |
| ES (1) | ES2061720T3 (es) |
| HU (1) | HUT46741A (es) |
| IE (2) | IE63004B1 (es) |
| IL (1) | IL86245A (es) |
| NZ (1) | NZ224470A (es) |
| PL (1) | PL272245A1 (es) |
| PT (1) | PT87394B (es) |
| ZA (1) | ZA883238B (es) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR27832A (tr) * | 1987-04-29 | 1995-08-31 | Monsanto Co | Zararli ucucu hasarata mukavim bitkiler. |
| ES2074999T3 (es) * | 1987-05-20 | 1995-10-01 | Ciba Geigy Ag | Plantas de zea mays y plantas de zea mays transgenicas regeneradas de protoplastos o celulas derivadas de protoplastos. |
| US5350689A (en) * | 1987-05-20 | 1994-09-27 | Ciba-Geigy Corporation | Zea mays plants and transgenic Zea mays plants regenerated from protoplasts or protoplast-derived cells |
| JPH02500566A (ja) * | 1987-08-17 | 1990-03-01 | プラント・ジェネティック・システムズ・エヌ・ブイ | バチルス・スリンギエンシスからのdna配列で形質転換された植物 |
| FI890917A7 (fi) * | 1988-03-02 | 1989-09-03 | Schweizerische Eidgenossenschaft | Menetelmä transgeenisten kasvien valmistamiseksi |
| GB8806643D0 (en) * | 1988-03-21 | 1988-04-20 | Ici Plc | Genetic manipulation |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| CA2017544A1 (en) * | 1989-05-29 | 1990-11-29 | Gunther Neuhaus | Process for the production of transgenic plants |
| DK168302B1 (da) * | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
| US5550318A (en) * | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US6803499B1 (en) | 1989-08-09 | 2004-10-12 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| EP0814166A3 (en) * | 1989-08-09 | 1998-05-13 | DeKalb Genetics Corporation | Methods and compositions for the production of stably transformed fertile monocot plants and cells thereof |
| US6329574B1 (en) | 1990-01-22 | 2001-12-11 | Dekalb Genetics Corporation | High lysine fertile transgenic corn plants |
| US5484956A (en) * | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| WO1991010725A1 (en) * | 1990-01-22 | 1991-07-25 | Dekalb Plant Genetics | Fertile transgenic corn plants |
| US6777589B1 (en) * | 1990-01-22 | 2004-08-17 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| DE4013099A1 (de) * | 1990-04-25 | 1991-10-31 | Hoechst Ag | Verfahren zur transformation somatischer embryonen von nutzpflanzen |
| DK0535060T3 (da) * | 1990-06-15 | 1995-07-17 | Hoechst Schering Agrevo Gmbh | Antifungisk polypeptid samt fremgangsmåde til dets fremstilling |
| US6395966B1 (en) | 1990-08-09 | 2002-05-28 | Dekalb Genetics Corp. | Fertile transgenic maize plants containing a gene encoding the pat protein |
| US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
| AU643563B2 (en) * | 1990-11-01 | 1993-11-18 | Sapporo Breweries Limited | Method for preparing transformed plant |
| ES2260886T3 (es) * | 1990-11-23 | 2006-11-01 | Bayer Bioscience N.V. | Procedimiento para transformar plantas monocotiledoneas. |
| US5384253A (en) * | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| UA48104C2 (uk) * | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| US6326527B1 (en) | 1993-08-25 | 2001-12-04 | Dekalb Genetics Corporation | Method for altering the nutritional content of plant seed |
| US6118047A (en) | 1993-08-25 | 2000-09-12 | Dekalb Genetic Corporation | Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction |
| US5780709A (en) * | 1993-08-25 | 1998-07-14 | Dekalb Genetics Corporation | Transgenic maize with increased mannitol content |
| US5693506A (en) * | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
| US5750870A (en) * | 1994-06-17 | 1998-05-12 | Agritope, Inc. | Plant genetic transformation methods and transgenic plants |
| US5736369A (en) * | 1994-07-29 | 1998-04-07 | Pioneer Hi-Bred International, Inc. | Method for producing transgenic cereal plants |
| HUT76841A (en) * | 1994-07-29 | 1997-11-28 | Pioneer Hi Bred Int | Transgenic cereal plants |
| EP0861021B1 (en) * | 1995-10-13 | 2009-09-23 | Dow Agrosciences LLC | Modified bacillus thuringiensis gene for lepidopteran control in plants |
| US6017534A (en) | 1996-11-20 | 2000-01-25 | Ecogen, Inc. | Hybrid Bacillus thuringiensis δ-endotoxins with novel broad-spectrum insecticidal activity |
| AP9901541A0 (en) | 1996-11-20 | 1999-06-30 | Ecogen Inc | Broad-spectrum delta-endotoxins. |
| US6713063B1 (en) | 1996-11-20 | 2004-03-30 | Monsanto Technology, Llc | Broad-spectrum δ-endotoxins |
| US6121436A (en) | 1996-12-13 | 2000-09-19 | Monsanto Company | Antifungal polypeptide and methods for controlling plant pathogenic fungi |
| AR012335A1 (es) | 1997-04-03 | 2000-10-18 | Dekalb Genetics Corp | Planta de maiz transgenica fertil y metodo para prepararla, dichas plantas endogamica y cruzada resistentes al glifosato, metodos para cultivar eincrementar el rendimiento de maiz, producir forraje, alimento para seres humanos, almidon, y criar plantas. |
| US6040497A (en) * | 1997-04-03 | 2000-03-21 | Dekalb Genetics Corporation | Glyphosate resistant maize lines |
| US6573101B1 (en) * | 1998-02-12 | 2003-06-03 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
| US6121521A (en) * | 1998-04-01 | 2000-09-19 | Novartis Ag | Chimeric insecticidal protein and DNA coding therefor |
| GB0002814D0 (en) | 2000-02-09 | 2000-03-29 | Univ York | Nucleic acids and their uses |
| CA2492917C (en) | 2002-07-19 | 2011-10-18 | University Of South Carolina | Compositions and methods for the modulation of gene expression in plants |
| WO2004013333A2 (de) | 2002-07-26 | 2004-02-12 | Basf Plant Science Gmbh | Revertierung der negativ-selektiven wirkung von negativen markerproteinen als selektionsverfahren |
| EP1502954A1 (en) | 2003-07-31 | 2005-02-02 | greenovation Biotech GmbH | Utilisation of constructs comprising recombination sequence motifes for enhancing gene expression in moss |
| EP1682667B1 (en) | 2003-11-10 | 2010-05-26 | Icon Genetics GmbH | Rna virus-derived plant expression system |
| EP1616959A1 (en) | 2004-07-07 | 2006-01-18 | Icon Genetics AG | Biological safe transient protein expression in plants |
| EA023885B1 (ru) | 2005-10-13 | 2016-07-29 | МОНСАНТО ТЕКНОЛОДЖИ, ЭлЭлСи | Конструкция рекомбинантной днк для индуцирования стерильности в трансгенном растении, стерильные трансгенные растения и способы получения гибридных семян |
| US8153863B2 (en) | 2007-03-23 | 2012-04-10 | New York University | Transgenic plants expressing GLK1 and CCA1 having increased nitrogen assimilation capacity |
| GB0709835D0 (en) | 2007-05-22 | 2007-07-04 | Plant Bioscience Ltd | Composition and method for modulating plant root hair development |
| GB2465748B (en) | 2008-11-25 | 2012-04-25 | Algentech Sas | Plant cell transformation method |
| GB2465749B (en) | 2008-11-25 | 2013-05-08 | Algentech Sas | Plant cell transformation method |
| GB2467167B (en) | 2009-01-26 | 2013-09-11 | Algentech Sas | Gene targeting in plants |
| IN2012DN00324A (es) | 2009-06-15 | 2015-05-08 | Plant Bioscience Ltd | |
| BR112012002454A2 (pt) | 2009-08-05 | 2017-07-04 | Chromocell Corp | plantas, micróbios e organismos melhorados |
| EP2357239A1 (en) | 2009-10-29 | 2011-08-17 | Universität zu Köln | Methods and means for a selectable marker system in plants |
| GB201008720D0 (en) | 2010-05-25 | 2010-07-07 | Univ Aberdeen | RxLR-leader peptides and protein translocation |
| WO2012058762A1 (en) | 2010-11-04 | 2012-05-10 | Medicago Inc. | Plant expression system |
| CN103635483B (zh) | 2011-07-01 | 2016-11-09 | 孟山都技术公司 | 用于选择性调控蛋白质表达的方法和组合物 |
| US10190128B2 (en) | 2013-03-22 | 2019-01-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kits comprising plus-sense single stranded RNA viral vectors and methods for producing polypeptides using the kits |
| ES2706499T3 (es) | 2013-08-14 | 2019-03-29 | Inst Of Genetics And Developmental Biology | Métodos de modulación del tamaño de la semilla y de los órganos de plantas |
| GB201319876D0 (en) | 2013-11-11 | 2013-12-25 | Plant Bioscience Ltd | Methods of modulating seed and organ size in plants |
| US10563213B2 (en) | 2014-03-27 | 2020-02-18 | Medicago Inc. | Modified CPMV enhancer elements |
| RU2731295C2 (ru) | 2014-07-11 | 2020-09-01 | Медикаго Инк. | Модификация продуцирования белков в растениях |
| JP2018524345A (ja) | 2015-07-02 | 2018-08-30 | メディカゴ インコーポレイテッド | ジャスモン酸経路アクチベーター |
| EP3260542A1 (en) | 2016-06-20 | 2017-12-27 | Algentech | Protein production in plant cells |
| WO2019185129A1 (en) | 2018-03-27 | 2019-10-03 | The University Court Of The University Of Glasgow | Bacterial pathogen derived resistance in plants |
| WO2022260849A1 (en) | 2021-06-09 | 2022-12-15 | Nant Holdings Ip, Llc | Methods and systems for producing a protein of interest in a plant |
| EP4598944A2 (en) | 2022-10-03 | 2025-08-13 | The Regents of the University of California | Circumventing barriers to hybrid crops from genetically distant crosses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0090033A1 (en) * | 1981-10-01 | 1983-10-05 | International Plant Research Institute | Process for the genetic modification of cereals with transformation vectors |
| AU9054882A (en) * | 1981-10-01 | 1983-04-27 | International Plant Research Institute | Process for the genetic modification of cerials with transformation vectors |
| BR8404834A (pt) * | 1983-09-26 | 1985-08-13 | Agrigenetics Res Ass | Metodo para modificar geneticamente uma celula vegetal |
| CA1208146A (en) * | 1983-10-27 | 1986-07-22 | Tai-Kin Wong | Method of transferring genes into cells |
| EP0160692A1 (en) * | 1983-11-03 | 1985-11-13 | DE WET, Johannes Martenis Jacob | Method for the transfer of exogenous genes in plants using pollen as a vector |
| EP0257472A3 (en) * | 1986-08-14 | 1989-10-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Transgenic monocotyledonous plants, seeds thereof and process for the preparation of the plants |
| IL84459A (en) * | 1986-12-05 | 1993-07-08 | Agracetus | Apparatus and method for the injection of carrier particles carrying genetic material into living cells |
| TR27832A (tr) * | 1987-04-29 | 1995-08-31 | Monsanto Co | Zararli ucucu hasarata mukavim bitkiler. |
-
1988
- 1988-05-03 ES ES88810280T patent/ES2061720T3/es not_active Expired - Lifetime
- 1988-05-03 CA CA000565754A patent/CA1328236C/en not_active Expired - Fee Related
- 1988-05-03 DE DE3887375T patent/DE3887375T2/de not_active Expired - Fee Related
- 1988-05-03 IL IL8624588A patent/IL86245A/en not_active IP Right Cessation
- 1988-05-03 HU HU882260A patent/HUT46741A/hu unknown
- 1988-05-03 DK DK240088A patent/DK240088A/da not_active Application Discontinuation
- 1988-05-03 PT PT87394A patent/PT87394B/pt not_active IP Right Cessation
- 1988-05-03 NZ NZ224470A patent/NZ224470A/en unknown
- 1988-05-03 AU AU15508/88A patent/AU615905B2/en not_active Ceased
- 1988-05-03 EP EP93810412A patent/EP0574356A1/en not_active Ceased
- 1988-05-03 EP EP88810280A patent/EP0290395B1/en not_active Expired - Lifetime
- 1988-05-03 IE IE132388A patent/IE63004B1/en not_active IP Right Cessation
- 1988-05-03 AT AT88810280T patent/ATE100858T1/de not_active IP Right Cessation
- 1988-05-03 IE IE940815A patent/IE940815L/xx unknown
- 1988-05-04 KR KR1019880005222A patent/KR880014104A/ko not_active Withdrawn
- 1988-05-04 PL PL27224588A patent/PL272245A1/xx unknown
- 1988-05-04 CN CN88102354A patent/CN1030442A/zh active Pending
- 1988-05-04 JP JP63109847A patent/JPS63301792A/ja active Pending
- 1988-05-04 BR BR8802175A patent/BR8802175A/pt not_active Application Discontinuation
- 1988-05-05 ZA ZA883238A patent/ZA883238B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE100858T1 (de) | 1994-02-15 |
| DE3887375T2 (de) | 1994-06-09 |
| DK240088D0 (da) | 1988-05-03 |
| HUT46741A (en) | 1988-11-28 |
| PT87394B (pt) | 1992-09-30 |
| AU1550888A (en) | 1988-11-10 |
| IE63004B1 (en) | 1995-03-08 |
| ZA883238B (en) | 1990-01-31 |
| BR8802175A (pt) | 1988-12-06 |
| EP0290395B1 (en) | 1994-01-26 |
| EP0574356A1 (en) | 1993-12-15 |
| IE940815L (en) | 1988-11-05 |
| IE881323L (en) | 1988-11-05 |
| EP0290395A3 (en) | 1990-11-28 |
| CA1328236C (en) | 1994-04-05 |
| EP0290395A2 (en) | 1988-11-09 |
| KR880014104A (ko) | 1988-12-22 |
| DE3887375D1 (de) | 1994-03-10 |
| IL86245A (en) | 1995-01-24 |
| PT87394A (pt) | 1989-05-31 |
| DK240088A (da) | 1988-11-06 |
| NZ224470A (en) | 1991-06-25 |
| PL272245A1 (en) | 1989-02-06 |
| CN1030442A (zh) | 1989-01-18 |
| AU615905B2 (en) | 1991-10-17 |
| JPS63301792A (ja) | 1988-12-08 |
| IL86245A0 (en) | 1988-11-15 |
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