ES2061966T3 - Mejoras introducidas en la sintesis de derivados 6-metilenicos de androsta-1,4-dieno-3,17-diona. - Google Patents

Mejoras introducidas en la sintesis de derivados 6-metilenicos de androsta-1,4-dieno-3,17-diona.

Info

Publication number
ES2061966T3
ES2061966T3 ES89300673T ES89300673T ES2061966T3 ES 2061966 T3 ES2061966 T3 ES 2061966T3 ES 89300673 T ES89300673 T ES 89300673T ES 89300673 T ES89300673 T ES 89300673T ES 2061966 T3 ES2061966 T3 ES 2061966T3
Authority
ES
Spain
Prior art keywords
methyleneic
diona
dieno
androsta
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89300673T
Other languages
English (en)
Inventor
Antonio Longo
Paolo Lombardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of ES2061966T3 publication Critical patent/ES2061966T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVO PROCEDIMIENTO PARA PREPARAR INHIBIDORES DE AROMATASA CONOCIDOS, DE FORMULA(I), EN LA QUE R1 Y R3 SON INDEPENDIENTEMENTE H O ALQUILO DE 1 A 6 C; R2 ES H, HALOGENO O ALQUILO DE 1 A 6 C; Y R4 ES H O F. EL PROCEDIMIENTO CONSISTE EN SOMETER A REACCION DE MANMICH A UN COMPUESTO DE FORMULA(II) EN LA QUE LOS SUSTITUYENTES R1 A R4 SON LOS ANTES DEFINIDOS, Y R ES UN ALQUILO DE CADENA CORTA, Y DESPUES DESHIDROGENAR EL DERIVADO 6 - METILEN - 3 - OXO - DELTA - 4 ESTEROIDICO OBTENIDO.
ES89300673T 1988-01-26 1989-01-25 Mejoras introducidas en la sintesis de derivados 6-metilenicos de androsta-1,4-dieno-3,17-diona. Expired - Lifetime ES2061966T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888801697A GB8801697D0 (en) 1988-01-26 1988-01-26 Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione

Publications (1)

Publication Number Publication Date
ES2061966T3 true ES2061966T3 (es) 1994-12-16

Family

ID=10630548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89300673T Expired - Lifetime ES2061966T3 (es) 1988-01-26 1989-01-25 Mejoras introducidas en la sintesis de derivados 6-metilenicos de androsta-1,4-dieno-3,17-diona.

Country Status (13)

Country Link
US (1) US4990635A (es)
EP (1) EP0326340B1 (es)
JP (1) JP2721002B2 (es)
KR (1) KR0132570B1 (es)
AT (1) ATE98253T1 (es)
CA (1) CA1319680C (es)
DE (1) DE68911157T2 (es)
ES (1) ES2061966T3 (es)
FI (1) FI91070C (es)
GB (1) GB8801697D0 (es)
HU (1) HU204064B (es)
IL (1) IL88396A (es)
SU (1) SU1757470A3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121484A1 (de) * 1991-06-26 1993-01-07 Schering Ag Verfahren zur herstellung von 6-methylensteroiden
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
ATE548375T1 (de) * 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
DE102007026636A1 (de) 2007-06-06 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17α-Acetoxy-6-methylenpregn-4-en-3,20-dion, Medroxyprogesteronacetat und Megestrolacetat
NZ581667A (en) * 2007-06-25 2012-03-30 Scinopharm Taiwan Ltd Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
CN101686969A (zh) * 2007-06-25 2010-03-31 台湾神隆股份有限公司 依西美坦的多晶型物
CN101429224B (zh) * 2007-11-07 2012-05-02 江苏希迪制药有限公司 1,4-双烯-6-亚甲基甾体化合物的合成方法及中间体
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
ES2605960T3 (es) 2010-09-14 2017-03-17 Endece, Llc Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
US4416821A (en) * 1982-02-17 1983-11-22 The Upjohn Company Process for preparing 16-methylene steroids
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
DE3338212C2 (de) * 1983-10-18 1995-05-18 Schering Ag 1-Methyl-androsta-1,4,6-trien-3,17-dione, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
JPH01224395A (ja) 1989-09-07
SU1757470A3 (ru) 1992-08-23
IL88396A (en) 1992-12-01
EP0326340A3 (en) 1990-03-14
DE68911157T2 (de) 1994-04-07
JP2721002B2 (ja) 1998-03-04
AU607565B2 (en) 1991-03-07
ATE98253T1 (de) 1993-12-15
EP0326340B1 (en) 1993-12-08
CA1319680C (en) 1993-06-29
AU2759888A (en) 1989-07-27
HU204064B (en) 1991-11-28
GB8801697D0 (en) 1988-02-24
KR890011904A (ko) 1989-08-23
FI91070C (fi) 1994-05-10
FI91070B (fi) 1994-01-31
DE68911157D1 (de) 1994-01-20
HUT49368A (en) 1989-09-28
FI890302A0 (fi) 1989-01-20
US4990635A (en) 1991-02-05
IL88396A0 (en) 1989-06-30
FI890302L (fi) 1989-07-27
KR0132570B1 (ko) 1998-04-14
EP0326340A2 (en) 1989-08-02

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