ES2063271T3 - Antagonistas de leucotrienos. - Google Patents
Antagonistas de leucotrienos.Info
- Publication number
- ES2063271T3 ES2063271T3 ES90306438T ES90306438T ES2063271T3 ES 2063271 T3 ES2063271 T3 ES 2063271T3 ES 90306438 T ES90306438 T ES 90306438T ES 90306438 T ES90306438 T ES 90306438T ES 2063271 T3 ES2063271 T3 ES 2063271T3
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- alkyl
- cor3
- trifluoromethylthio
- tetrazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/02—Monothiocarboxylic acids
- C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/08—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
COMPONENTES REPRESENTADOS POR LA SIGUIENTE FORMULA ESTRUCTURAL (I): EN DONDE Q ES 0 O 2; R1 ES (L)A-(CH2)B-(T)C-M A ES 0 O 1; B ES 3 A 14; C ES 0 O 1; L Y T SON INDEPENDIENTEMENTE OXIGENO O CH2; M ES ALQUIL C1-4, ETINIL, TRIFLUOROMETIL, ISOPROPENIL, FURANIL, TIENIL, CICLOHEXIL O FENIL OPCIONALMENTE MONOSUSTITUIDO CON BR, CL, CF3, ALCOXI, ALQUIL, METILTIO, O TRIFLUOROMETILTIO; Y ES (CHX)(CH2)P-Z EN DONDE Z ES COR3, O TETRAZOLIL; EN EL QUE R3 ES OH, NH2, ARILOXI, O ALCOXI C1-6; P ES 0,1 O 2; X ES OH, O ALCOXI; R ES -(CH2)P-W; D ES 0 A 6; W ES FENIL SUSTITUIDO CON B,C O D; B ES -(CH2)P-V, EN DONDE P ES 0 A 6 Y V ES COR3, SO3H, SO2H, SO2NH2, COCH2OH, CHOHCH2OH, O TETRAZOLIL, CON R3 COMO SE DEFINIO ANTES; C Y D SON INDEPENDIENTEMENTE SELECCIONADOS DE H, OH, F, CL, BR, CF3, ALQUIL, ALCOXI, METILTIO, TRIFLUOROMETILTIO, NO2, NH2, NHALQUIL O CALQUILCO-; O SUS SALES ACEPTABLES FARMACEUTICAMENTE, PUEDEN SER USADOS EN LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ASMA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36604689A | 1989-06-14 | 1989-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2063271T3 true ES2063271T3 (es) | 1995-01-01 |
Family
ID=23441449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90306438T Expired - Lifetime ES2063271T3 (es) | 1989-06-14 | 1990-06-13 | Antagonistas de leucotrienos. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0403249B1 (es) |
| JP (1) | JPH0324050A (es) |
| KR (1) | KR910000632A (es) |
| AT (1) | ATE104955T1 (es) |
| AU (1) | AU645253B2 (es) |
| CA (1) | CA2018437A1 (es) |
| DE (1) | DE69008428T2 (es) |
| DK (1) | DK0403249T3 (es) |
| ES (1) | ES2063271T3 (es) |
| IE (1) | IE902141A1 (es) |
| MX (1) | MX21139A (es) |
| NZ (1) | NZ234009A (es) |
| PT (1) | PT94373A (es) |
| ZA (1) | ZA904583B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214201A (en) * | 1991-12-12 | 1993-05-25 | Smithkline Beecham Corporation | Crystallization of optical isomers of leukotriene antagonists |
| CA2131787A1 (en) * | 1992-03-12 | 1993-09-16 | Masahiko Shikano | Antipruritic |
| ZA939517B (en) * | 1992-12-23 | 1995-01-31 | Smithkline Beecham Corp | Process |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8700647A1 (es) * | 1984-10-11 | 1986-11-16 | Raychem Corp | Procedimiento para la preparacion de un compuesto carbonilo aromatico |
| CA1334200C (en) * | 1987-06-24 | 1995-01-31 | James Simpson Frazee | Leukotriene antagonists |
| AU610528B2 (en) * | 1987-10-29 | 1991-05-23 | Smithkline Beckman Corporation | Leukotriene antagonists |
| JPH01153658A (ja) * | 1987-12-08 | 1989-06-15 | E R Squibb & Sons Inc | ヘテロ含有置換基を有するフェニルヒドロキサム酸類 |
| US4954513A (en) * | 1988-12-23 | 1990-09-04 | Smithkline Beecham Corporation | Leukotriene antagonists |
-
1990
- 1990-06-07 CA CA002018437A patent/CA2018437A1/en not_active Abandoned
- 1990-06-08 AU AU56902/90A patent/AU645253B2/en not_active Ceased
- 1990-06-11 NZ NZ234009A patent/NZ234009A/xx unknown
- 1990-06-12 PT PT94373A patent/PT94373A/pt not_active Application Discontinuation
- 1990-06-13 MX MX2113990A patent/MX21139A/es unknown
- 1990-06-13 DK DK90306438.4T patent/DK0403249T3/da active
- 1990-06-13 ZA ZA904583A patent/ZA904583B/xx unknown
- 1990-06-13 ES ES90306438T patent/ES2063271T3/es not_active Expired - Lifetime
- 1990-06-13 IE IE214190A patent/IE902141A1/en unknown
- 1990-06-13 AT AT9090306438T patent/ATE104955T1/de not_active IP Right Cessation
- 1990-06-13 DE DE69008428T patent/DE69008428T2/de not_active Expired - Fee Related
- 1990-06-13 JP JP2154990A patent/JPH0324050A/ja active Pending
- 1990-06-13 EP EP90306438A patent/EP0403249B1/en not_active Expired - Lifetime
- 1990-06-14 KR KR1019900008738A patent/KR910000632A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0324050A (ja) | 1991-02-01 |
| ZA904583B (en) | 1992-05-27 |
| AU5690290A (en) | 1990-12-20 |
| DE69008428T2 (de) | 1994-11-24 |
| DE69008428D1 (de) | 1994-06-01 |
| DK0403249T3 (da) | 1994-05-24 |
| CA2018437A1 (en) | 1990-12-14 |
| NZ234009A (en) | 1993-02-25 |
| MX21139A (es) | 1993-12-01 |
| IE902141A1 (en) | 1991-01-02 |
| EP0403249B1 (en) | 1994-04-27 |
| ATE104955T1 (de) | 1994-05-15 |
| IE902141L (en) | 1990-12-14 |
| AU645253B2 (en) | 1994-01-13 |
| PT94373A (pt) | 1991-02-08 |
| EP0403249A1 (en) | 1990-12-19 |
| KR910000632A (ko) | 1991-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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