ES2063801T3 - Esteroides 3beta,17beta-hidroxi-sustituidos y compuestos esteroidicos relacionados. - Google Patents

Esteroides 3beta,17beta-hidroxi-sustituidos y compuestos esteroidicos relacionados.

Info

Publication number
ES2063801T3
ES2063801T3 ES89120006T ES89120006T ES2063801T3 ES 2063801 T3 ES2063801 T3 ES 2063801T3 ES 89120006 T ES89120006 T ES 89120006T ES 89120006 T ES89120006 T ES 89120006T ES 2063801 T3 ES2063801 T3 ES 2063801T3
Authority
ES
Spain
Prior art keywords
hydroxy
17beta
3beta
components
steroid compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89120006T
Other languages
English (en)
Inventor
O'neal J Johnston
Gene W Holbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2063801T3 publication Critical patent/ES2063801T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL PRESENTE INVENTO ESTA DIRIGIDO A UN GRUPO DE COMPONENTES QUE SON ESTEROIDES HIDROXI-B17,B3, Y ESTRUCTURAS ESTEROIDALES RELACIONADAS. ESOS COMPONENTES SON INHIBIDORES AROMATOSOS, Y ASI, REGULAR O INHIBIR LA CONVERSION DE ANDROGENOS A ESTROGENOS. ESOS COMPONENTES DEBEN SER UTILIZADOS PARA TRATAR LAS CONDICIONES POTENCIADAS POR LA PRESENCIA DE ESTROGENOS. ESOS COMPONENTES EXHIBEN UN PRINCIPIO MAS LENTO DE ACCION Y UNA VIDA MEDIA RELATIVA MAS LARGA A LOS INHIBIDORES AROMATOSOS ESTEROIDALES (ALQUINIL-2)-10 DESCUBIERTOS EN U.S. PATENT 4,322,416.
ES89120006T 1988-10-27 1989-10-27 Esteroides 3beta,17beta-hidroxi-sustituidos y compuestos esteroidicos relacionados. Expired - Lifetime ES2063801T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/263,091 US4882322A (en) 1988-10-27 1988-10-27 3β,17β-hydroxy-substituted steroids and related steroidal compounds

Publications (1)

Publication Number Publication Date
ES2063801T3 true ES2063801T3 (es) 1995-01-16

Family

ID=23000340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89120006T Expired - Lifetime ES2063801T3 (es) 1988-10-27 1989-10-27 Esteroides 3beta,17beta-hidroxi-sustituidos y compuestos esteroidicos relacionados.

Country Status (18)

Country Link
US (1) US4882322A (es)
EP (1) EP0366144B1 (es)
JP (1) JP2750621B2 (es)
KR (1) KR900006360A (es)
CN (1) CN1042363A (es)
AT (1) ATE111478T1 (es)
AU (1) AU619608B2 (es)
CA (1) CA2001264C (es)
DE (1) DE68918219T2 (es)
DK (1) DK533189A (es)
ES (1) ES2063801T3 (es)
FI (1) FI895084A7 (es)
HU (1) HU204065B (es)
IL (1) IL92103A0 (es)
NO (1) NO173097C (es)
NZ (1) NZ231107A (es)
PT (1) PT92113B (es)
ZA (1) ZA898025B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166201A (en) * 1990-11-30 1992-11-24 Merrell Dow Pharmaceuticals Inc. 2β,19-ethylene bridged steroids as aromatase inhibitors
AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
WO2005097141A2 (en) * 2003-11-24 2005-10-20 Merck & Co., Inc. Estrogen receptor modulators
WO2005051972A1 (en) * 2003-11-24 2005-06-09 Merck & Co., Inc. Estrogen receptor modulators
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP1945240B1 (en) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN103555806B (zh) * 2013-11-16 2015-05-13 江南大学 一种高效利用亚麻刺盘孢霉合成7α-羟基-雄甾烯酮的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives

Also Published As

Publication number Publication date
DE68918219D1 (de) 1994-10-20
PT92113B (pt) 1995-06-30
HU204065B (en) 1991-11-28
AU619608B2 (en) 1992-01-30
NO894276D0 (no) 1989-10-26
JPH02174793A (ja) 1990-07-06
FI895084A7 (fi) 1990-04-28
JP2750621B2 (ja) 1998-05-13
HUT52113A (en) 1990-06-28
DK533189D0 (da) 1989-10-26
KR900006360A (ko) 1990-05-08
NO173097C (no) 1993-10-27
PT92113A (pt) 1990-04-30
NO894276L (no) 1990-04-30
ATE111478T1 (de) 1994-09-15
US4882322A (en) 1989-11-21
EP0366144A1 (en) 1990-05-02
CN1042363A (zh) 1990-05-23
ZA898025B (en) 1990-07-25
HU895457D0 (en) 1990-01-28
FI895084A0 (fi) 1989-10-26
IL92103A0 (en) 1990-07-12
DE68918219T2 (de) 1995-02-02
EP0366144B1 (en) 1994-09-14
AU4367989A (en) 1990-05-31
NO173097B (no) 1993-07-19
NZ231107A (en) 1992-03-26
CA2001264C (en) 2001-05-01
CA2001264A1 (en) 1990-04-27
DK533189A (da) 1990-04-28

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