ES2064117T3 - Dispositivo osmotico oral para el suministro de nicotina. - Google Patents

Dispositivo osmotico oral para el suministro de nicotina.

Info

Publication number
ES2064117T3
ES2064117T3 ES91913859T ES91913859T ES2064117T3 ES 2064117 T3 ES2064117 T3 ES 2064117T3 ES 91913859 T ES91913859 T ES 91913859T ES 91913859 T ES91913859 T ES 91913859T ES 2064117 T3 ES2064117 T3 ES 2064117T3
Authority
ES
Spain
Prior art keywords
nicotine
salt
base
compartment
osmotic device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913859T
Other languages
English (en)
Inventor
Virgil A Place
Patric S-L Wong
Brian L Barclay
Jerry D Childers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2064117T3 publication Critical patent/ES2064117T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UN DISPOSITIVO OSMOTICO (10) PARA LA DISTRIBUCION SISTEMICA CONTROLADA DE NICOTINA A TRAVES DE UNA MEMBRANA DE LA MUCOSA ORAL DE UN PACIENTE HUMANO. EL DISPOSITIVO (10) TIENE UN TAMAÑO Y UNA FORMA QUE LO ADAPTA PARA SER COMODAMENTE RETENIDO EN LA BOCA DURANTE PERIODOS DE TIEMPO PROLONGADOS. EL DISPOSITIVO (10) COMPRENDE UNA PARED SEMIPERMEABLE (12) QUE RODEA UN COMPARTIMIENTO (13) QUE CONTIENE UNA SAL DE NICOTINA (14) Y OPCIONALMENTE UNA SAL ALCALINA QUE PUEDE REACCIONAR CON LA SAL DE NICOTINA EN PRESENCIA DE AGUA PARA FORMAR UNA BASE DE NICOTINA. LA BASE DE NICOTINA SE DISTRIBUYE DESDE EL COMPARTIMIENTO (13) A TRAVES DE UN CONDUCTO (17) DE LA PARED (12). LA SAL DE NICOTINA MUESTRA UNA ESTABILIDAD Y UNA VIDA UTIL BUENAS MIENTRAS QUE LA BASE DE NICOTINA MUESTRA UNA ABSORCION EXCELENTE A TRAVES DE LAS MEMBRANAS DE LAS MUCOSAS ORALES.
ES91913859T 1990-07-23 1991-07-18 Dispositivo osmotico oral para el suministro de nicotina. Expired - Lifetime ES2064117T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55743490A 1990-07-23 1990-07-23

Publications (1)

Publication Number Publication Date
ES2064117T3 true ES2064117T3 (es) 1995-01-16

Family

ID=24225371

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913859T Expired - Lifetime ES2064117T3 (es) 1990-07-23 1991-07-18 Dispositivo osmotico oral para el suministro de nicotina.

Country Status (16)

Country Link
EP (1) EP0540623B1 (es)
JP (1) JPH06502622A (es)
AT (1) ATE111351T1 (es)
AU (1) AU652952B2 (es)
CA (1) CA2047418A1 (es)
DE (1) DE69104045T2 (es)
DK (1) DK0540623T3 (es)
ES (1) ES2064117T3 (es)
FI (1) FI930272A7 (es)
IE (1) IE62597B1 (es)
MX (1) MX9100277A (es)
NO (1) NO930134L (es)
NZ (1) NZ239033A (es)
PT (1) PT98374A (es)
WO (1) WO1992001445A1 (es)
ZA (1) ZA915648B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200194A (en) * 1991-12-18 1993-04-06 Alza Corporation Oral osmotic device
GB9523752D0 (en) * 1995-11-21 1996-01-24 Pfizer Ltd Pharmaceutical formulations
DE19646392A1 (de) * 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
ZA979605B (en) * 1996-11-25 1998-05-21 Alza Corp Ascending-dose dosage form.
PT946151E (pt) * 1996-11-25 2006-07-31 Alza Corp Forma de dosagem de dose crescente
AU1713501A (en) * 1999-11-23 2001-06-04 Robert Gordon University, The Bilayered buccal tablets comprising nicotine
US20050061339A1 (en) * 2001-12-21 2005-03-24 Henri Hansson Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
EP1617823B1 (en) * 2003-01-24 2019-01-09 Nicachet AB A pouch comprising a nicotine composition for transmucosal delivery
DE102008038556A1 (de) * 2008-06-26 2009-12-31 Eswegee Vliesstoff Gmbh Vliesstoff zur Verwendung als feuchtedurchlässiges, mikroporöses Genussmittelverpackungsmaterial
EP2233134A1 (en) 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
SE535587C2 (sv) * 2011-03-29 2012-10-02 Chill Of Sweden Ab Produkt innehållande ett fritt nikotinsalt och en ej vattenlöslig påse
US10532046B2 (en) * 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US10966936B2 (en) 2015-12-30 2021-04-06 Corium, Inc. Systems comprising a composite backing and methods for long term transdermal administration
WO2017223402A1 (en) 2016-06-23 2017-12-28 Corium International, Inc. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
EP3490544A1 (en) 2016-07-27 2019-06-05 Corium International, Inc. Memantine transdermal delivery systems
WO2018022814A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
CN116270551A (zh) 2016-07-27 2023-06-23 考里安有限责任公司 通过盐至中性药物原位转化的组合物、透皮贴剂及应用
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021053A (en) * 1989-07-14 1991-06-04 Alza Corporation Oral osmotic device with hydrogel driving member

Also Published As

Publication number Publication date
FI930272A0 (fi) 1993-01-22
NO930134L (no) 1993-01-21
EP0540623B1 (en) 1994-09-14
PT98374A (pt) 1994-01-31
MX9100277A (es) 1992-02-28
NO930134D0 (no) 1993-01-15
FI930272L (fi) 1993-01-22
IE62597B1 (en) 1995-02-08
JPH06502622A (ja) 1994-03-24
WO1992001445A1 (en) 1992-02-06
ATE111351T1 (de) 1994-09-15
ZA915648B (en) 1992-05-27
AU652952B2 (en) 1994-09-15
IE912517A1 (en) 1992-01-29
FI930272A7 (fi) 1993-01-22
CA2047418A1 (en) 1992-01-24
EP0540623A1 (en) 1993-05-12
NZ239033A (en) 1994-04-27
AU8292491A (en) 1992-02-18
DE69104045D1 (de) 1994-10-20
DE69104045T2 (de) 1995-02-02
DK0540623T3 (da) 1995-03-20

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