ES2064736T3 - Inhibidores de colesterol-esterasa no absorbibles para disminuir la absorcion de colesterol. - Google Patents

Inhibidores de colesterol-esterasa no absorbibles para disminuir la absorcion de colesterol.

Info

Publication number
ES2064736T3
ES2064736T3 ES90907923T ES90907923T ES2064736T3 ES 2064736 T3 ES2064736 T3 ES 2064736T3 ES 90907923 T ES90907923 T ES 90907923T ES 90907923 T ES90907923 T ES 90907923T ES 2064736 T3 ES2064736 T3 ES 2064736T3
Authority
ES
Spain
Prior art keywords
cholesterol
absorbable
decrease
esterase inhibitors
absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907923T
Other languages
English (en)
Inventor
Louis George Lange Iii
Curtis A Spilburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/340,868 external-priority patent/US5017565A/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2064736T3 publication Critical patent/ES2064736T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO Y COMPOSICIONES QUE INHIBEN LA ESTERASA DE COLESTEROL PANCREATICA Y LA LIPASA DE TRIGLICERIDA Y ASI REDUCIR EL COLESTEROL Y LAS TRIGLICERIDAS EN EL FLUJO SANGUINEO.
ES90907923T 1989-04-20 1990-04-20 Inhibidores de colesterol-esterasa no absorbibles para disminuir la absorcion de colesterol. Expired - Lifetime ES2064736T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/340,868 US5017565A (en) 1989-04-20 1989-04-20 Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
US07/429,398 US5063210A (en) 1989-04-20 1989-10-31 Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption

Publications (1)

Publication Number Publication Date
ES2064736T3 true ES2064736T3 (es) 1995-02-01

Family

ID=26992276

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907923T Expired - Lifetime ES2064736T3 (es) 1989-04-20 1990-04-20 Inhibidores de colesterol-esterasa no absorbibles para disminuir la absorcion de colesterol.

Country Status (10)

Country Link
US (1) US5063210A (es)
EP (1) EP0469079B1 (es)
JP (1) JPH0819001B2 (es)
AT (1) ATE114970T1 (es)
AU (1) AU633569B2 (es)
CA (1) CA2053258C (es)
DE (1) DE69014870T2 (es)
DK (1) DK0469079T3 (es)
ES (1) ES2064736T3 (es)
WO (1) WO1990012579A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005084610A2 (en) 2004-02-27 2005-09-15 Bioiberica, S.A. New therapeutic use for a group of sulphated polysaccharides

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WO1989008456A1 (en) * 1988-03-15 1989-09-21 The Jewish Hospital Of St. Louis Inhibition of intestinal cholesterol and fatty acid absorption
US5519010A (en) * 1989-02-06 1996-05-21 Taiho Pharmaceutical Co., Ltd. Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component
US5173408A (en) * 1989-11-13 1992-12-22 Lange Louis George Iii Mammalian pancreatic cholesterol esterase
DE4011285A1 (de) * 1990-04-06 1991-10-10 Steigerwald Arzneimittelwerk Arzneimittel zur behandlung von hyperlipidaemie und/oder atherosklerose
US5616570A (en) * 1991-10-18 1997-04-01 Lange, Iii; Louis G. Use of non-absorbable synthetic sulfated polysaccharides to decrease cholesterol absorbtion
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor
WO1995003058A1 (en) * 1993-07-21 1995-02-02 Belorussky Nauchno-Issledovatelsky Institut Kardiologii Oxidized starch derivatives as anti-aggregation, anticoagulant and anti-arrhythmic agents
JPH09511263A (ja) * 1993-12-23 1997-11-11 ヴィアノヴァ レジンズ アクチエンゲゼルシャフト 水希釈可能な、アクリレート共重合体に基づくラッカー結合剤の製法およびその使用
AU2453295A (en) * 1994-09-20 1996-04-19 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
CA2160440C (en) * 1994-10-13 1998-08-25 Louis G. Lange, Iii Method of manufacturing non-absorbable synthetic sulfated polysaccharides
US7071174B1 (en) 1994-10-13 2006-07-04 Cv Therapeutics, Inc. Method and composition for inhibiting cholesterol esterase
US5696087A (en) * 1994-12-01 1997-12-09 Oklahoma Medical Research Foundation Method and compositions for reducing cholesterol absorption
US5821226A (en) * 1994-12-01 1998-10-13 Oklahoma Medical Research Foundation BAL C-tail drug delivery molecules
US5681819A (en) * 1994-12-01 1997-10-28 Oklahoma Medical Research Foundation Method and compositions for reducing cholesterol absorption
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
US6342218B1 (en) 1997-02-14 2002-01-29 Oklahoma Medical Research Foundation Method for treatment of SLE
US6264937B1 (en) * 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
JPH11349485A (ja) * 1998-06-09 1999-12-21 Shirako Co Ltd 肝臓障害改善剤
WO2000009123A1 (en) * 1998-08-14 2000-02-24 F. Hoffmann-La Roche Ag Pharmaceutical compositions containing lipase inhibitors and chitosan
US6462029B1 (en) * 1999-02-23 2002-10-08 Econugenics Compositions and methods for treating mammals with modified alginates and modified pectins
CA2384696A1 (en) * 1999-10-02 2001-04-12 The Government Of The United States Of America Fibroblast growth factor-5 (fgf-5) is a tumor associated t-cell antigen
JP4601100B2 (ja) * 1999-11-08 2010-12-22 三生医薬株式会社 マスティックの油液を内包した軟カプセル
EP1307263B1 (en) * 2000-07-28 2005-04-20 F. Hoffmann-La Roche Ag New use of lipase inhibitors
RU2241462C2 (ru) * 2000-07-28 2004-12-10 Ф. Хоффманн-Ля Рош Аг Новая фармацевтическая композиция
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US6946151B2 (en) * 2002-11-12 2005-09-20 Ayurvedic-Life International, Llc Therapeutic compositions
US6949261B2 (en) 2002-11-12 2005-09-27 Ayurvedic-Life International, Llc Compositions for diabetes treatment and prophylaxis
US20080138326A1 (en) * 2006-12-06 2008-06-12 Kaneka Corporation Method for cancer treatment, carcinogenesis suppression or mitigation of adverse reactions of anticancer agents
DE102007035322B4 (de) * 2007-07-25 2011-11-17 Friedrich-Schiller-Universität Jena Verfahren zur Herstellung wasserlöslicher, niedrig substituierter Cellulosesulfate
EP2234493A4 (en) * 2007-12-21 2011-05-25 Univ Cincinnati THERAPEUTIC USE OF CARBOXYLESTERLIPASE INHIBITORS
US8022347B2 (en) * 2008-06-23 2011-09-20 Ricoh Company, Ltd. Optical scanning device, image forming apparatus, and optical scanning method having a plurality of light intensity control devices with a switching unit
GB0920633D0 (en) 2009-11-25 2010-01-13 Rdbiomed Ltd Inhibition of pancreatic lipase
US20150133551A1 (en) 2012-05-03 2015-05-14 Beth Israel Deaconess Medical Center, Inc. Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
EP2972399B1 (en) 2013-03-15 2020-09-02 Beth Israel Deaconess Medical Center, Inc. Lipids that increase insulin sensitivity and methods of using the same

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GB871590A (en) * 1958-08-18 1961-06-28 Riker Laboratories Inc Water soluble antilipemic salts of sulphated polysaccharides
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US3148114A (en) * 1959-11-20 1964-09-08 American Cyanamid Co Method of reducing cholesterol levels
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US3627872A (en) * 1968-04-08 1971-12-14 Upjohn Co Oral treatment of hyper-cholesteremia in mammals and birds with ether-type anion exchangers of polysaccharides
DE2037942C2 (de) * 1970-04-15 1982-11-18 Biomed Research, Inc., 90048 Los Angeles, Calif. Arzneimittel enthaltend ein "aktives" Chondroitinsulfat als Wirkstoff zur Verhinderung des Auftretens atherosklerotischer Läsionen und zur Verhinderung des Auftretens von Herzanfällen
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JPS5790002A (en) * 1980-11-27 1982-06-04 Asahi Chem Ind Co Ltd Cellulose sulfate containing heparin-like property and its production
IT1144697B (it) * 1981-04-06 1986-10-29 Texcontor Ets Derivato semi-sintetico della chitina processo per la sua preparazione e composizioni terapeutiche che lo comprendono come principio attivo
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FR2538404B1 (es) * 1982-12-28 1985-08-23 Anic Spa
FR2555993B1 (fr) * 1983-12-06 1986-11-07 Anic Spa Chitosanes 6-sulfates et procede pour leur preparation
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005084610A2 (en) 2004-02-27 2005-09-15 Bioiberica, S.A. New therapeutic use for a group of sulphated polysaccharides

Also Published As

Publication number Publication date
WO1990012579A1 (en) 1990-11-01
EP0469079A1 (en) 1992-02-05
US5063210A (en) 1991-11-05
EP0469079B1 (en) 1994-12-07
JPH04503813A (ja) 1992-07-09
CA2053258C (en) 1998-02-10
ATE114970T1 (de) 1994-12-15
CA2053258A1 (en) 1990-10-21
DK0469079T3 (da) 1995-07-10
DE69014870T2 (de) 1995-04-27
AU5535690A (en) 1990-11-16
AU633569B2 (en) 1993-02-04
DE69014870D1 (de) 1995-01-19
JPH0819001B2 (ja) 1996-02-28

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