ES2064801T3 - Emusion estable apropiada para la administracion farmaceutica, procedimiento para su obtencion, y emulsion para la aplicacion como medicamento. - Google Patents

Emusion estable apropiada para la administracion farmaceutica, procedimiento para su obtencion, y emulsion para la aplicacion como medicamento.

Info

Publication number
ES2064801T3
ES2064801T3 ES91107066T ES91107066T ES2064801T3 ES 2064801 T3 ES2064801 T3 ES 2064801T3 ES 91107066 T ES91107066 T ES 91107066T ES 91107066 T ES91107066 T ES 91107066T ES 2064801 T3 ES2064801 T3 ES 2064801T3
Authority
ES
Spain
Prior art keywords
emulsion
procedure
obtaining
application
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91107066T
Other languages
English (en)
Inventor
Karin Dr Schaupp
Josef Polzer
Johannes Dr Kerbl
Kurt Lanthaler
Stanley Stewart Prof Davis
Clive Dr Washington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6406167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2064801(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Knoll GmbH filed Critical Knoll GmbH
Application granted granted Critical
Publication of ES2064801T3 publication Critical patent/ES2064801T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UNA EMULSION, SUSTANCIA EFICAZ Y ESTABLE DEL TIPO DE ACEITE EN AGUA CON UN FOSFOLIPIDO COMO EMULGADOR, EN DONDE UN ACTIVADOR SOLUBLE EN UNA FASE LIPIDA LLEVA UNO O VARIOS GRUPOS BASICOS, HIDROHOB Y SOLUBLE, Y TIENE UN VALOR PK DE AL MENOS 7,5. ESTE GRUPO DE FASE ACUOSA SE AJUSTA SOBRE UN VALOR PH DE ACIDO Y DA UNA FASE DISPERSA DESPUES DE DILUIR LA EMULSION PREPARADA PARA SU APLICACION SOBRE EL CONTENIDO DE GRASA DE UN % EN PESO DE 0,08, UN POTENCIAL DE ZETA POSITIVO DE AL MENOS + 15, PREFERIBLEMENTE, SIN EMBARGO DE +30 MV.
ES91107066T 1990-05-11 1991-05-02 Emusion estable apropiada para la administracion farmaceutica, procedimiento para su obtencion, y emulsion para la aplicacion como medicamento. Expired - Lifetime ES2064801T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4015108A DE4015108A1 (de) 1990-05-11 1990-05-11 Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe

Publications (1)

Publication Number Publication Date
ES2064801T3 true ES2064801T3 (es) 1995-02-01

Family

ID=6406167

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91107066T Expired - Lifetime ES2064801T3 (es) 1990-05-11 1991-05-02 Emusion estable apropiada para la administracion farmaceutica, procedimiento para su obtencion, y emulsion para la aplicacion como medicamento.

Country Status (8)

Country Link
US (1) US5496818A (es)
EP (1) EP0456106B1 (es)
JP (1) JPH04226911A (es)
AT (1) ATE114966T1 (es)
CA (1) CA2041920A1 (es)
DE (2) DE4015108A1 (es)
DK (1) DK0456106T3 (es)
ES (1) ES2064801T3 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4124252A1 (de) * 1991-07-22 1993-01-28 Knoll Ag Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung
DE4201527A1 (de) * 1992-01-21 1993-07-22 Knoll Ag Lecithinhaltige loesungen mit levemopamil
IL101241A (en) * 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
US5720973A (en) * 1993-02-18 1998-02-24 Knoll Aktiengesellschaft Preparation of colloidal aqueous solutions of active substances of low solubility and a lipid therefor
DE4305003A1 (de) * 1993-02-18 1994-08-25 Knoll Ag Verfahren zur Herstellung kolloidaler wäßriger Lösungen schwer löslicher Wirkstoffe
JPH0827018A (ja) * 1994-07-22 1996-01-30 Sanwa Kagaku Kenkyusho Co Ltd 生理活性ペプチド又は蛋白質を含有する薬剤組成物
US5635536A (en) * 1994-12-07 1997-06-03 Pharmacia & Upjohn Aktiebolag Emulsion suitable for administering a sphingolipid
JP2690276B2 (ja) * 1995-01-10 1997-12-10 科学技術振興事業団 静電結合型高分子ミセル薬物担体とその薬剤
DE19733625A1 (de) * 1997-07-28 1999-02-04 Lancaster Group Gmbh Dekorative kosmetische O/W-Emulsion
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
CN1221249C (zh) * 1998-08-19 2005-10-05 斯凯伊药品加拿大公司 普鲁泊福的可注射水分散体
US7153525B1 (en) * 2000-03-22 2006-12-26 The University Of Kentucky Research Foundation Microemulsions as precursors to solid nanoparticles
DE10225122A1 (de) * 2002-06-06 2003-12-18 Goldschmidt Ag Th Hochkonzentrierte wässrige Dispersionen enthaltend hydrophobe mikrofeine Metalloxidpartikel und Dispergierhilfsmittel
AU2003302226A1 (en) * 2002-09-24 2004-06-30 University Of Kentucky Research Foundation Nanoparticle-based vaccine delivery system containing adjuvant
US7468394B1 (en) * 2003-03-11 2008-12-23 Amphastar Pharmaceuticals, Inc. Sterile pharmaceutical composition and process for a solution of propofol emulsion having microbial growth retardation
US7780831B2 (en) * 2003-07-07 2010-08-24 The University Of North Carolina At Chapel Hill Assays for detection of von willebrand factor (vWF) multimers and for degradation of vWF by agents such as ADAMTS13 and related methods
CN100367951C (zh) * 2005-12-16 2008-02-13 石药集团恩必普药业有限公司 丁苯酞静脉乳剂及其应用
US20100099775A1 (en) * 2008-10-17 2010-04-22 Alpharx Inc. Method for ameliorating of post-anesthetic recovery
WO2011094219A1 (en) * 2010-01-26 2011-08-04 Hendrick-Andre Kroon Vesicular formulations
US9446056B2 (en) 2014-02-11 2016-09-20 Dr. Reddy's Laboratories Ltd. Parenteral compositions of celecoxib

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592859A (en) * 1982-09-16 1986-06-03 Ramu International Oil-in-water or water-in-oil suspensions and uses therefor
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US4816247A (en) * 1985-09-11 1989-03-28 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
DE3634389A1 (de) * 1986-10-09 1988-04-21 Knoll Ag Verwendung von anipamil
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
GB8919172D0 (en) * 1989-08-23 1989-10-04 Univ Nottingham Useful composition

Also Published As

Publication number Publication date
DE59103745D1 (de) 1995-01-19
CA2041920A1 (en) 1991-11-12
ATE114966T1 (de) 1994-12-15
US5496818A (en) 1996-03-05
EP0456106A2 (de) 1991-11-13
DK0456106T3 (da) 1995-02-13
DE4015108A1 (de) 1991-11-14
EP0456106B1 (de) 1994-12-07
EP0456106A3 (en) 1992-11-19
JPH04226911A (ja) 1992-08-17

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